Similar studies for GEO DataSets (Select 2336) - GEO DataSets

Select item 23361.

Caffeine effect on TOR complex 1 mutant: dose response

Analysis of Tor1p mutant treated with up to 9 mM caffeine. Tor1p is a component of TOR complex 1 (TORC1), a regulator of growth in eukaryotic cells. I1954V and W2176R substitutions in Tor1p confer resistance to caffeine. Results provide insight into the function and activity of TORC1.

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array, log2 ratio, 3 dose, 2 genotype/variation sets

Platform:: GPL2763
Series:: GSE4586
6 Samples

Download data: GPR

DataSet

Accession:: GDS2336

ID:: 2336

Select item 2000045862.

Effect of caffeine on WT versus 3HA-TOR1 [I1954V + W2176R]

(Submitter supplied) Comparing the effects of caffeine on cells expressing either WT 3HA-TOR1 or 3HA-TOR1 [I1954V + W2176R] Keywords: Dose response in wild type versus mutant

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Dataset:: GDS2336
Platform:: GPL2763
6 Samples

Download data: GPR, TXT

Series

Accession:: GSE4586

ID:: 200004586

Select item 2000045843.

Comparing effects of rapamycin and caffeine on gene expression in YPD media

(Submitter supplied) To identify genes influenced by rapamycin and caffeine in strains W303a, S288c, and Sigma 2000 Keywords: Drug dose response

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Dataset:: GDS2338
Platform:: GPL2763
12 Samples

Download data: GPR, TXT

Series

Accession:: GSE4584

ID:: 200004584

Select item 23384.

Caffeine and rapamycin effect on various wild type strains

Analysis of W303, S288c, and Sigma 2000 wild type strains treated with rapamycin or caffeine. Results provide insight into the influence of genetic background on the response to each drug.

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array, log2 ratio, 2 agent, 3 strain sets

Platform:: GPL2763
Series:: GSE4584
6 Samples

Download data: GPR

DataSet

Accession:: GDS2338

ID:: 2338

Select item 2000040495.

Time-course studies of three cell wall interfering drugs on gene expression in yeast

(Submitter supplied) Caffeine is a natural purine analog that elicits pleiotropic effects, which ultimately lead to cell death by a mechanism that is still largely uncharacterized. This drug can activate the PKC1-MAPK cell integrity pathway, as shown by phosphorylation of Mpk1 kinase. However, and contrary to expectation, the caffeine-induced hyperphosphorylation of Mpk1 was accompanied by a negligible activation of its downstream targets Rlm1 and SBF transcription factors, which suggested that the fortification of the cell wall induced by caffeine was independent on the MAP kinase activation. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Dataset:: GDS2914
Platform:: GPL3250
36 Samples

Download data

Series

Accession:: GSE4049

ID:: 200004049

Select item 29146.

Caffeine effect: time course and dose response

Analysis of cells treated with a low dose of caffeine at 2 mM or a high one at 20 mM for 5 , 15, or 90 minutes. Caffeine is a natural purine analogue that elicits pleiotropic effects leading to cell death. Results provide insight into the mechanism of action of caffeine.

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array, log ratio, 3 agent, 2 dose, 3 time sets

Platform:: GPL3250
Series:: GSE4049
36 Samples

Download data

DataSet

Accession:: GDS2914

ID:: 2914

Select item 2000076607.

Sch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae

(Submitter supplied) The Target Of Rapamycin (TOR) protein is a Ser/Thr kinase that functions in two distinct multiprotein complexes: TORC1 and TORC2. These conserved complexes regulate many different aspects of cell growth in response to intra- and extracellular cues. Here we report the first bona fide substrate of yeast TORC1: the AGC-kinase Sch9. Six amino acids in the c-terminus of Sch9 are directly phosphorylated by TORC1. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL884
17 Samples

Download data: TXT

Series

Accession:: GSE7660

ID:: 200007660

Select item 2001821868.

Transcript profiling of Candida albicans tor1 kinase mutants

(Submitter supplied) This study analyses the effects of truncation of the gene encoding Tor1 kinase in Candida albicans. The study involves a mutant tetO-TOR1-Del381 which has the N terminal regulator HEAT repeats deleted compared to a full length tetO-TOR1 strain and a heterozygous TOR1/tor1 control. Cell were grown in vitro in YEPD broth at 30˚C. In shut off experiments, doxycycline (30 µg.ml) was added to cultures to shut off the tetO promoter and inhibit Tor1 expression.

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL24041
20 Samples

Download data: TXT

Series

Accession:: GSE182186

ID:: 200182186

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000333209.

Expression data of yeast genes treated with rapamycin and compound CID 3528206

(Submitter supplied) Compound CID 3538206 inhibits yeast TORC1 activity and functionally mimic rapamycin. We used microarrays to compare the global gene expression with the treatment of CID 3528206 and rapamycin.