Similar studies for GEO DataSets (Select 2346) - GEO DataSets

Select item 23461.

Reticulocyte binding-like homolog 2b knockout effect on 3D7 parasites

Analysis of reticulocyte binding-like homolog 2b (PfRh2b) null mutant 3D7 parasites. D10 isolate naturally lacks PfRh2b. Silencing of PfRh2b, a key invasion ligand, leads to altered invasion receptor dependency. Results provide insight into the molecular basis for invasion via an alternate pathway.

Organism:: Plasmodium falciparum

Type:: Expression profiling by array, transformed count, 2 development stage, 5 genotype/variation, 2 strain sets

Platform:: GPL1892
Series:: GSE3877
10 Samples

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DataSet

Accession:: GDS2346

ID:: 2346

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000038772.

Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions

(Submitter supplied) Central to the pathology of malaria disease are the repeated cycles of parasite invasion and destruction of human erythrocytes. In Plasmodium falciparum, the most virulent species causing malaria, erythrocyte invasion involves several specific receptor–ligand interactions that direct the pathway used to invade the host cell, with parasites varying in their dependency on these different pathways. Gene disruption of a key invasion ligand in the 3D7 parasite strain, the P. more...

Organism:: Plasmodium falciparum

Type:: Expression profiling by array

Dataset:: GDS2346
Platform:: GPL1892
10 Samples

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Series

Accession:: GSE3877

ID:: 200003877

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000028783.

Molecular mechanism for switching of P.falciparum invasion pathways into human erythrocytes

(Submitter supplied) The malaria parasite, Plasmodium falciparum, exploits multiple ligand-receptor interactions, called invasion pathways, to invade the host erythrocyte. Strains of P.falciparum vary in their dependency on sialated red cell receptors for invasion. We show that switching from sialic acid-dependent to –independent invasion is reversible and depends on parasite ligand utilisation. Expression of P.falciparum reticulocyte-binding like homologue 4 (PfRh4) correlates with sialic acid-independent invasion and PfRh4 is essential for switching invasion pathways. more...

Organism:: Plasmodium falciparum

Type:: Expression profiling by array

Platform:: GPL1892
3 Samples

Download data: CEL

Series

Accession:: GSE2878

ID:: 200002878

Select item 2001416534.

An intrinsic oscillator drives the blood stage cycle of the malaria parasite, Plasmodium falciparum

(Submitter supplied) The blood-stage infection of the malaria parasite, Plasmodium falciparum, exhibits a 48-hour developmental cycle that culminates in the synchronous release of parasites from red blood cells, triggering 48-hour fever cycles in the host. This cycle could be driven extrinsically by host circadian processes, or by a parasite-intrinsic oscillator. To distinguish between hypotheses, we examined the P. falciparum cycle in an in vitro culture system that lacks extrinsic cues from the host and show that P. more...

Organism:: Plasmodium falciparum

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL27825 GPL21078
91 Samples

Download data: TXT

Series

Accession:: GSE141653

ID:: 200141653

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001299495.

Whole transcriptome profiling of static and suspension-cultured schizonts of the P. falciparum strains W2mef and Dd2.

(Submitter supplied) Overview: RNA-seq was used to profile the whole-transcriptome gene expression of highly replicated schizont-stage cultures of W2mef and Dd2 grown under static and suspended conditions. Methods: Transcript profiles of schizont stages of static and suspended W2mef and Dd2 were generated by RNA sequencing. Two to eight replicates were sequenced per sample. Illumina stranded TruSeq libraries were sequenced using an Illumina MiSeq. more...

Organism:: Plasmodium falciparum

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19269
33 Samples

Download data: CSV

Series

Accession:: GSE129949

ID:: 200129949

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002457356.

Stem cell technology provides novel tools to understand the impact of human variation on malaria

(Submitter supplied) Plasmodium falciparum parasites have a complex life cycle, but the most clinically relevant stage of the disease is the invasion of erythrocytes and the proliferation of the parasite in the blood. The influence of human genetic traits on malaria has been known for a long time, however understanding the role of the proteins involved is hampered by the anuclear nature of erythrocytes that makes them inaccessible to genetic tools. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL28270
100 Samples

Download data: IDAT, XLSX

Series

Accession:: GSE245735

ID:: 200245735

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001561027.

Evolutionarily selected overexpression of the cytokine BAFF enhances mucosal immune response against P. falciparum

(Submitter supplied) A variant of the TNFSF13B gene (BAFF-var) increases the production of the cytokine BAFF, up-regulating humoral immunity and increasing the risk for certain autoimmune diseases. BAFF-var was evolutionarily advantageous, most likely by increasing resistance to malaria infection. We assessed experimentally the role of BAFF-var in response to malaria antigens. Lysates of erythrocytes infected with Plasmodium falciparum (iRBCs) or left uninfected (uRBCs, control) were used to treat PBMCs with distinct BAFF genotypes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
42 Samples

Download data: TXT

Series

Accession:: GSE156102

ID:: 200156102

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

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