Similar studies for GEO DataSets (Select 3480) - GEO DataSets

Select item 34801.

Sox10 depletion effect on Schwannoma cell line

Analysis of RT4D6 Schwannoma cells depleted for Sox10, an Sry-related HMG-Box transcription factor. Sox10 is important in the development of several cell lineages including neural crest stem cells and the derivative peripheral glial cells and melanocytes. Results identify Sox10 gene targets.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL1355
Series:: GSE12007
4 Samples

Download data: CEL

DataSet

Accession:: GDS3480

ID:: 3480

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000120072.

Identification of Sox10 target genes by comparative expression profiling

(Submitter supplied) RT4D6 Schwannoma cells were treated with siRNA specific for Sox10 and a mutant siRNA. Total RNA from the cells were used to screen for differentially expressed genes.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3480
Platform:: GPL1355
4 Samples

Download data: CEL

Series

Accession:: GSE12007

ID:: 200012007

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000816693.

DNase Hypersensitivity Peaks from Rat Schwann Cells

(Submitter supplied) We utilized DNase-Seq to identify open chromatin regions within Schwann cells. This data was used in conjunction with sequence conservation and transcription factor binding site prediction to identify putative cis-regulatory elements critical for Schwann cells. We used three independent biological replicates, and for our studies used sample 'barcode4' as a representative sample for all three. DNase HSS peaks were identified using F-Seq and HOMER, and overlapped to prioritize candidate regions. more...

Organism:: Rattus norvegicus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL14844
3 Samples

Download data: BW

Series

Accession:: GSE81669

ID:: 200081669

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000255014.

Sox10 controls migration of melanoma cells through multiple regulatory target genes

(Submitter supplied) It is believed that the inherent differentiation program of melanocytes during embryogenesis predisposes melanoma cells to high frequency of metastasis. Sox10, a transcription factor expressed in neural crest stem cells and a subset of progeny lineages, plays a key role in the development of melanocytes. We show that B16F10 melanoma cells transfected with siRNA specific for Sox10 display reduced migratory activity which in turn indicated that a subset of transcriptional regulatory target genes of Sox10 are likely to be involved in migration and metastasis of melanoma cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6238
6 Samples

Download data: TXT

Series

Accession:: GSE25501

ID:: 200025501

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000699505.

Genomic Analysis Reveals Distinct Mechanisms and Functional Classes of SOX10-Regulated Genes in Melanocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9250 GPL17021 GPL16570
14 Samples

Download data: CEL, TXT, WIG

Series

Accession:: GSE69950

ID:: 200069950

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000699496.

Genomic Analysis Reveals Distinct Mechanisms and Functional Classes of SOX10-Regulated Genes in Melanocytes [ChIP-Seq]

(Submitter supplied) We performed ChIP-Seq analysis of SOX10, histone H3 lysine 27 acetylation (H3K27ac) and H3K27 trimethylation (H3K27me3) in melanocytes to profile the genomic binding sites of SOX10 and the chromatin landscape. In parallel, we generated Sox10 haploinsufficient cell lines using gene knockout approaches and conducted microarray gene expression analysis to identify functional gene targets of SOX10 transcriptional regulation in melanocytes. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9250 GPL17021
8 Samples

Download data: TXT, WIG

Series

Accession:: GSE69949

ID:: 200069949

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000698607.

Genomic Analysis Reveals Distinct Mechanisms and Functional Classes of SOX10-Regulated Genes in Melanocytes [gene expression]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
6 Samples

Download data: CEL

Series

Accession:: GSE69860

ID:: 200069860

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000817098.

RNA-Seq experiments performed on rat Schwann (S16) cells

(Submitter supplied) We utilized RNA-Seq on rat Schwann (S16) cells to determine global gene expression. This information was generated as part of a larger effort to characterize cis-regulatory elements and global gene expression within Schwann cells. To achieve this, we generated RPKM values across two independent biological replicates. This dataset was also used to predict cis-regulatory element function on genes following CRISPR knockout studies.

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL14844
4 Samples

Download data: TXT

Series

Accession:: GSE81709

ID:: 200081709

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000122629.

Genome-Wide Discovery of STAT3 Functional Binding Sites

(Submitter supplied) STAT3 is a transcription factor playing a crucial role in inflammation, immunity and oncogenesis, able to induce distinct subsets of target genes in different cell types or under different conditions. Identification of direct transcriptional targets however has only defined a relatively limited set of genes, not sufficient to explain its variegated functions. In order to improve our understanding of the STAT3 transcriptional network we decided to develop a computational approach for the discovery of STAT3 functional binding sites. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL81
8 Samples

Download data: CEL

Series

Accession:: GSE12262

ID:: 200012262

PubMed Full text in PMC Similar studies Analyze with GEO2R

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