GEO DataSets

Analysis of adrenal glands from genetically/hereditary hypertensive (BPH/2) and genetically/hereditary low-blood pressure (BPL/1) 12-week old adults. Results provide insight into molecular mechanisms underlying the pathogenesis of genetic hypertension.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL81

Series:

GSE19342

6 Samples

Download data: CEL, CHP

(Submitter supplied) The objective of the experiment is to determine the genes differentially expressed in the adrenal gland of adult (12-week) BPH and BPL mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3777

Platform:

GPL81

6 Samples

Download data: CEL, CHP

(Submitter supplied) We performed Affymetrix MG-U74Av2 GeneChip experiements on mRNA from the adrenal glands of the BPH hypertensive and BPL hypotensive mouse strains. All mice were aged-matched at 5 weeks. We obtained the mice from Jackson Laboratories, Bar Harbor, ME. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1011

Platform:

GPL81

6 Samples

Download data: CEL, EXP

Expression profiling of adrenal glands from blood pressure high (BPH) males at the prehypertensive stage. BPH males examined at 5 weeks of age. Results compared to gene expression in SHR rat model, and provides insight into mechanisms of hypertension shared across species.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 strain sets

Platform:

GPL81

Series:

GSE1674

6 Samples

Download data: CEL, EXP

(Submitter supplied) We measured gene expression in the adrenal glands of the Spontaneously Hypertensive Rat (SHR) and Wistar-Kyoto rat (WKY) using Affymetrix RG-U34A GeneChips. All rats were aged-matched at 4-weeks. The rats were obtained from the colonies at the Univeristy of California San Diego, La Jolla, CA. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1464

Platform:

GPL85

6 Samples

Download data: CEL, EXP

Comparison of adrenal gland from spontaneously hypertensive (SHR) males at 4 weeks of age, a prehypertensive stage, and normotensive Wistar-Kyoto. Results compared to gene expression in hypertensive BPH mouse model, and provides insight into mechanisms of hypertension shared across species.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL85

Series:

GSE1675

6 Samples

Download data: CEL, EXP

(Submitter supplied) Hypertension is a condition with major cardiovascular and renal complications, affecting nearly a billion patients worldwide. Few validated gene targets are available for pharmacological intervention, so there is a need to identify new biological pathways regulating blood pressure and containing novel targets for treatment. The genetically hypertensive “blood pressure high” (BPH), normotensive “blood pressure normal” (BPN), and hypotensive "blood pressure low" (BPL) inbred mouse strains are an ideal system to study differences in gene expression patterns that may represent such biological pathways. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3672 GDS3673 GDS3674 GDS3675

Platform:

GPL9734

67 Samples

Download data: CEL

Analysis of kidney of genetically hypotensive BPL, normotensive BPN, and hypertensive BPH inbred strains. Results provide insight into the molecular pathways affected by hypertension in the kidney.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL9734

Series:

GSE19817

14 Samples

Download data: CEL

Analysis of liver of genetically hypotensive BPL, normotensive BPN, and hypertensive BPH inbred strains. Results provide insight into the molecular pathways affected by hypertension in the liver.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL9734

Series:

GSE19817

15 Samples

Download data: CEL

Analysis of heart of genetically hypotensive BPL, normotensive BPN, and hypertensive BPH inbred strains. Results provide insight into the molecular pathways affected by hypertension in the heart.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL9734

Series:

GSE19817

15 Samples

Download data: CEL

Analysis of aorta of genetically hypotensive BPL, normotensive BPN, and hypertensive BPH inbred strains. Results provide insight into the molecular pathways affected by hypertension in the aorta.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL9734

Series:

GSE19817

23 Samples

Download data: CEL

(Submitter supplied) Identification of hypothalamic genes whose expression differs between high blood pressure (BPH/2J) and normal blood pressure (BPN/3J) Schlager mouse strains at age 6 weeks (young) and 26 weeks (mature) using Affymetrix GeneChip® Mouse Gene 1.0 ST Arrays.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3895

Platform:

GPL6246

24 Samples

Download data: CEL

Analysis of hypothalamus from young (6 week-old) and adult (26 week-old) BPH/2J hypertensive males and age-/gender-matched normotensive BPN/3J controls. Results provide insight into molecular mechanisms underlying early and established neurogenic hypertension in hypothalamus.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 2 disease state, 2 strain sets

Platform:

GPL6246

Series:

GSE25076

24 Samples

Download data: CEL

(Submitter supplied) We evaluated the suitability of high-throughput transcriptomics approach to monitor terrestrial ecosystems. Free-living Mus spretus from several polluted sites of Huelva (Andalusia, SW Spain) were compared with mice from Doñana Biological Reserve (“Santa Olalla” lagoon (SOL) used as negative control). As most popular bioindicators, M. spretus is poorly represented in gene databases, therefore limiting the use of genomics in ecotoxicological studies. more...

Organism:

Mus musculus; Mus spretus

Type:

Expression profiling by array

Dataset:

GDS5331

Platform:

GPL4134

19 Samples

Download data: TXT

Analysis of Mus spretus livers from the polluted Domingo Rubio stream. Results provide insight into the biological effects of an industrial settlement on the liver of an aboriginal species.

Organism:

Mus musculus; Mus spretus

Type:

Expression profiling by array, count, 5 other sets

Platform:

GPL4134

Series:

GSE33663

19 Samples

Download data: TXT

(Submitter supplied) Analysis of kidneys from 12 week BPH/2J hypertensive and age matched normotensive BPN/3J controls - males and females. The results provide insights into the genes that are involved in hypertension in both males and females, as well as highlight mechanisms that underlye sex differences in hypertension. We show that female data can be used to refine candidate genes and pathways, as well as highlight potential mechanisms to explain the differences in prevalence and severity of disease between the sexes.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11533

24 Samples

Download data: CEL

(Submitter supplied) Male Dahl salt sensitive and Lewis rats (n=3 each) were fed an 8% NaCl diet starting at 5 weeks of age for 8 weeks. Total RNA was isolated with TRIzol reagent from DS and LEW kidneys and was subjected to microarray analysis. Keywords: animals with different genetic background comparison

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2710

Platform:

GPL1355

6 Samples

Download data

Analysis of kidneys from Dahl salt-sensitive males fed a high salt diet. The Dahl salt sensitive animal is used as a model of hypertension. Results combined with quantitative trait loci analyses to identify candidate genes that influence blood pressure levels.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL1355

Series:

GSE4800

6 Samples

Download data

(Submitter supplied) To obtain a comprehensive view of the transcriptional programs in prostatic stromal cells of different histological/pathological origin, we profiled 18 adult human stromal cell cultures from normal transition zone (TZ), normal peripheral zone (PZ), benign prostatic hyperplasia (BPH), and prostate cancer (CA) using cDNA microarrays. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4541

19 Samples

Download data

(Submitter supplied) We hypothesize that gene expression in the CBs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes. More specifically, (1) genes related to CB function are expressed less in the A/J mice compared to DBA/2J mice; (2) gene expression levels of morphogenic and trophic factors of the CB maybe significantly lower in the A/J mice than the DBA/2J mice. In order to test these hypotheses, we utilized microarray analysis to examine transcriptional differences between CBs of both strains of mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2466

Platform:

GPL1261

6 Samples

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