Similar studies for GEO DataSets (Select 3902) - GEO DataSets

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Items: 20

Select item 39021.

Chronic B-lymphocytic leukemia: peripheral blood

Analysis of peripheral blood from chronic B-lymphocytic leukemia (B-CLL) patients and healthy donors. MicroRNA miR-155 regulates hematopoietic cell development. Results provide insight into the role of miR-155 in the lymphoproliferative disorder B-CLL..

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state sets

Platform:: GPL570
Series:: GSE26725
17 Samples

Download data: CEL

DataSet

Accession:: GDS3902

ID:: 3902

Select item 2000267252.

Gene expression analysis of 12 B-cell Chronic Lymphocytic Leukemia samples and 5 CD19+ control samples

(Submitter supplied) Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of MIR155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3902
Platform:: GPL570
17 Samples

Download data: CEL

Series

Accession:: GSE26725

ID:: 200026725

Select item 2000336233.

Epigenetic regulation of miRNA in CLL [MCIp_hsa_miRNA_v3b]

(Submitter supplied) Genome-wide profiling of DNA methylation 35 kb upstream and 5 kb downstream of microRNAs in 24 CLL patients and B cells of 2 healthy donors versus a pool of 10 healthy donors.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL14805
26 Samples

Download data: TXT

Series

Accession:: GSE33623

ID:: 200033623

Select item 2000333474.

Epigenetic regulation of miRNA in CLL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array; Methylation profiling by genome tiling array

Platforms:: GPL14805 GPL14804
42 Samples

Download data: TXT

Series

Accession:: GSE33347

ID:: 200033347

Select item 2000333055.

Epigenetic regulation of miRNA in CLL [ChIP_hsa_miRNA_v3b]

(Submitter supplied) Genome-wide profiling of histone 3 lysine 4 trimethylation is used for identification of microRNA transcriptional start sites. Various cell types allow a broad range detection of putative promoters rather independent of tissue specific expression patterns. These data are used for identification of aberrant epigenetic regulation at the respective regions.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL14805
11 Samples

Download data: TXT

Series

Accession:: GSE33305

ID:: 200033305

Select item 2000333046.

Epigenetic regulation of miRNA in CLL [ChIP_hsa_miRNA_v2]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL14804
5 Samples

Download data: TXT

Series

Accession:: GSE33304

ID:: 200033304

Select item 2000515297.

Association between distinct gene and miRNA expression profiles and utilization of stereotyped subset #4 in the cells of CLL patients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL8227 GPL6244
471 Samples

Download data: CEL, TXT

Series

Accession:: GSE51529

ID:: 200051529

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000515288.

Association between distinct gene and miRNA expression profiles and utilization of stereotyped subset #4 in the cells of CLL patients [Gene Expression]

(Submitter supplied) Highly homologous B-cell receptors, stereotyped BCR, are expressed in a recurrent fraction of patients with chronic lymphocytic leukemia (CLL). In this study, we investigated the biological and molecular features of leukemic cells from 16 patients utilizing stereotyped subset #4 BCR (IGHV4-34) in a prospective cohort of 462 Binet stage A CLL patients. All subset #4 patients were characterized by the IGHV mutated gene configuration and by the absence of unfavorable cytogenetic lesions, and NOTCH1 and SF3B1 mutations. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
229 Samples

Download data: CEL

Series

Accession:: GSE51528

ID:: 200051528

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000515279.

Association between distinct gene and miRNA expression profiles and utilization of stereotyped subset #4 in the cells of CLL patients [MicroRNA Profiling]

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL8227
242 Samples

Download data: TXT

Series

Accession:: GSE51527

ID:: 200051527

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005277610.

Gene expression study in CLL of B-cell receptor triggering

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL6480 GPL11487
64 Samples

Download data: TXT

Series

Accession:: GSE52776

ID:: 200052776

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005277511.

Gene expression study in CLL of B-cell receptor triggering (miRNA study)

(Submitter supplied) The B-cell receptor (BCR) plays an important role in pathogenesis and progression of chronic lymphocytic leukemia (CLL). We investigated the BCR triggering-dependent microRNA modulation by stimulating CLL cells with immobilized anti-IgM. miRome of immobilized anti-IgM stimulated CLL cells (n=16) identified a substantial upregulation of miR-132 in both unmutated (UM) and mutated (M) IGHV subgroups. A parallel gene expression profile and an in-silico analysis to identify miR-132 target genes¸ allowed us to focus on SIRT1, that encodes for a histone deacetylase targeting several proteins including TP53. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL11487
32 Samples

Download data: TXT

Series

Accession:: GSE52775

ID:: 200052775

PubMed Full text in PMC Similar studies

Select item 20005277412.

Gene expression study in CLL of B-cell receptor triggering (mRNA Study)

(Submitter supplied) The B-cell receptor (BCR) plays an important role in pathogenesis and progression of chronic lymphocytic leukemia (CLL). We investigated the BCR triggering-dependent mRNA modulation by stimulating CLL cells with immobilized anti-IgM. miRome of immobilized anti-IgM stimulated CLL cells (n=16) identified a substantial upregulation of miR-132 in both unmutated (UM) and mutated (M) IGHV subgroups. A parallel gene expression profile and an in-silico analysis to identify miR-132 target genes¸ allowed us to focus on SIRT1, that encodes for a histone deacetylase targeting several proteins including TP53. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
32 Samples

Download data: TXT

Series

Accession:: GSE52774

ID:: 200052774

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006213713.

miRNA regulation by interleukin-4 (IL-4) in chronic lymphocytic leukemia (CLL)

(Submitter supplied) miRNA expression profiles of CLL cells and normal B cells (NBC) treated for 18 hr with 10 ng/ml IL-4, compared with culture with nothing (Ctrl) and the basal (Pre) samples.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL14767
44 Samples

Download data: TXT

Series

Accession:: GSE62137

ID:: 200062137

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011333614.

Linking aberrant chromatin features in chronic lymphocytic leukemia to deregulated transcription factor networks

(Submitter supplied) In chronic lymphocytic leukemia (CLL) a diverse set of genetic mutations is embedded in a deregulated epigenetic landscape that drives cancerogenesis. To elucidate the role of aberrant chromatin features, we mapped DNA methylation, 7 histone modifications, nucleosome positions, chromatin accessibility, binding of EBF1 and CTCF as well as the transcriptome of B cells from CLL patients and healthy donors. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL20301 GPL11154
519 Samples

Download data: BIGBED, BW

Series

Accession:: GSE113336

ID:: 200113336

PubMed Full text in PMC Similar studies

Select item 20011974415.

Enhancer profiling of chronic lymphocytic leukemia cells

(Submitter supplied) Enhancer profiling has emerged as a powerful approach for discovering the cis-regulatory elements that define transcriptional core regulatory circuits. Characteristic biochemical and biophysical attributes of chromatin mark active enhancer elements, which can be leveraged with genome-wide assay technologies for discovery. This includes chromatin immunoprecipitation followed by sequencing (ChIP-seq) for histone H3 acetylated lysine 27 (H3K27ac). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
36 Samples

Download data: BEDGRAPH, XLSX

Series

Accession:: GSE119744

ID:: 200119744

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20001606516.

mutated IGHV3-23 CLL

(Submitter supplied) Expression of stereotyped B cell receptors (BCR), i.e. non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes, complementarity-determining region-3 (HCDR3), and IGV light chains, identifies discrete clusters and represents a peculiar feature of chronic lymphocytic leukemia (CLL). Expression of IGHV3-23 characterized a CLL subset with peculiar molecular and clinical features.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
27 Samples

Download data: TXT

Series

Accession:: GSE16065

ID:: 200016065

Select item 20007654617.

17-DMAG treatment in primary CLL B cells

(Submitter supplied) We used microarrays to analyze gene expression following treatment of leukemic B cells with the Hsp90 inhibitor 17-DMAG. Gene expression profiling reveals the role of SOCS3 in cytokine signaling in CLL

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
5 Samples

Download data: CEL

Series

Accession:: GSE76546

ID:: 200076546

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20021629018.

HDAC1 regulates the chromatin landscape to control transcriptional dependencies in chronic lymphocytic leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL20301 GPL18573
71 Samples

Download data: BROADPEAK, NARROWPEAK

Series

Accession:: GSE216290

ID:: 200216290

PubMed Full text in PMC Similar studies

Select item 20021628919.

HDAC1 regulates the chromatin landscape to control transcriptional dependencies in chronic lymphocytic leukemia [miRNA-seq]

(Submitter supplied) Chronic lymphocytic leukemia (CLL) is a quiescent B-cell malignancy that depends on transcriptional dysregulation for survival. The histone deacetylases are transcriptional regulators whose role within the regulatory chromatin and consequence on the CLL transcriptome is poorly characterized. Here, we profiled and integrated the genome wide occupancy of HDAC1, BRD4, H3K27Ac and H3K9Ac signals with chromatin accessibility, Pol2 occupancy and target expression signatures in CLL cells. more...