Similar studies for GEO DataSets (Select 3929) - GEO DataSets

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Items: 20

Select item 39291.

Tobacco smoke effect on maternal and fetal cells

Analysis of peripheral blood leukocytes and placenta of pregnant smokers. Umbilical cord blood leukocytes of their newborns also examined. Maternal smoking has a negative effect on all stages of pregnancy. Results provide insight into molecular mechanisms underlying tobacco smoke-related defects.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state, 3 specimen sets

Platform:: GPL6883
Series:: GSE27272
183 Samples

Download data

DataSet

Accession:: GDS3929

ID:: 3929

Select item 2000272722.

Comprehensive Study of Tobacco Smoke-Related Transcriptome Alterations in Maternal and Fetal Cells

(Submitter supplied) Maternal smoking has a severe negative effect on all stages of pregnancy that in consequence impairs fetal growth and development. Tobacco smoke-related defects are well established at the clinical level; however, little is known about molecular mechanisms underlying these pathological conditions. We thus employed a genomic approach to determine transcriptome alterations induced by maternal smoking in pregnancy. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3929
Platform:: GPL6883
183 Samples

Download data: TXT

Series

Accession:: GSE27272

ID:: 200027272

Select item 2000180443.

Effect of maternal tobacco smoke exposure on the placental transcriptome

(Submitter supplied) Smoking in pregnancy increases a woman's risk of preterm delivery resulting in serious health problems during the newborn period, chronic lifelong disabilities (such as cerebral palsy, mental retardation and learning problems), and even death. Further, smoking women have placental problems such as placenta previa (a low-lying placenta that covers part or all of the opening of the uterus), placental abruption (in which the placenta peels away, partially or almost completely before delivery) often resulting in bleeding during delivery. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3793
Platform:: GPL6104
76 Samples

Download data: TXT

Series

Accession:: GSE18044

ID:: 200018044

Select item 37934.

Tobacco smoke effect on the placenta

Analysis of placentas of women who smoked during pregnancy. Smoking increases the risk of preterm delivery and complications such as placental previa and abruption. Results provide insight into the molecular basis of smoke-induced placental abnormalities.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 3 dose sets

Platform:: GPL6104
Series:: GSE18044
76 Samples

Download data

DataSet

Accession:: GDS3793

ID:: 3793

Select item 2000300325.

Deregulation of Gene Expression induced by Environmental Tobacco Smoke Exposure in Pregnancy

(Submitter supplied) Passive smoke intake by pregnant women may have detrimental effects such as spontaneous abortion, lower birth weight, stillbirth, and reduced infant lung function. To extend our knowledge on molecular effects of tobacco smoke exposure in pregnancy, we analyzed transcriptome alterations in passive smokers (PS) and compared them to those in active smokers (AS). Using Illumina Expression Beadchip with 24,526 transcript probes, gene expression patterns were assayed in placentas from PS (N=25) exposed to environmental tobacco smoke (ETS) throughout pregnancy and non-exposed (NS) counterparts (N=35), and in cord blood cells from their newborns. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6883
104 Samples

Download data: TXT

Series

Accession:: GSE30032

ID:: 200030032

Select item 2000047076.

Microarray Analysis of Differentially Expressed Genes in Placental Tissue of Severe Preeclampsia

(Submitter supplied) Pre-eclampsia is one of the most serious pregnancy-associated disorders, and is defined by hypertension (systolic blood pressure higher than 140mmHg or diastolic blood pressure higher than 90mmHg) with proteinuria (more than 0.3g/day). It is not a simple complication of pregnancy, but is rather a syndrome of multiple organ failure involving the liver, kidney, and lung, as well as coagulatory and neural systems. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2080
Platform:: GPL1708
14 Samples

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Series

Accession:: GSE4707

ID:: 200004707

Select item 20807.

Early and late onset severe preeclampsia: placenta

Analysis of placentas from patients with early or late onset severe preeclampsia. Preeclampsia is a serious pregnancy-associated disorder characterized by hypertension and proteinuria. Results provide insight into the pathogenesis of preeclampsia.

Organism:: Homo sapiens

Type:: Expression profiling by array, log10 ratio, 3 disease state sets

Platform:: GPL1708
Series:: GSE4707
14 Samples

Download data

DataSet

Accession:: GDS2080

ID:: 2080

Select item 2000074348.

Full-term placenta, smokers and non-smokers

(Submitter supplied) Gene expression in placenta from 5 smoking and 5 non-smoking mothers analyzed by Affymetrix Hg133_plus2 microarrays. Keywords: Toxic response

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2990
Platform:: GPL570
10 Samples

Download data: CEL

Series

Accession:: GSE7434

ID:: 200007434

Select item 29909.

Cigarette smoking effect on full-term placenta

Analysis of full-term placentas exposed to maternal cigarette smoke. The placenta produces and metabolizes steroids and xenobiotics. Results provide insight into the effects of maternal cigarette smoking on the placenta at term, with a focus on xenobiotic- and steroid-metabolizing genes.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 gender, 2 stress sets

Platform:: GPL570
Series:: GSE7434
10 Samples

Download data: CEL

DataSet

Accession:: GDS2990

ID:: 2990

Select item 20006040310.

The obese fetal transcriptome

(Submitter supplied) The objective of this study was to identify the tissue expression patterns and biological pathways enriched in term cord blood fetal RNA of obese women compared to lean In fetuses of obese women, 683 differentially regulated genes were identified.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
16 Samples

Download data: CEL

Series

Accession:: GSE60403

ID:: 200060403

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006182211.

Neurocognitive impairment at 18-24 months in children born preterm may originate in utero: a microarray study

(Submitter supplied) To characterize the molecular profile of the chorioamniotic membranes of preterm neonates with and without neurocognitive impairment at 18-24 months and (2) to determine if neonates who developed neurocognitive impairment can be identified at birth.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
28 Samples

Download data: TXT

Series

Accession:: GSE61822

ID:: 200061822

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013669112.

Characterization of the Placental Transcriptome through Mid to Late Gestation in the Mare

(Submitter supplied) The placenta is a dynamic organ which undergoes extensive remodeling throughout pregnancy to support, protect and nourish the developing fetus. Despite the importance of the placenta, very little is known about its gene expression beyond very early pregnancy and post-partum. Therefore, we utilized RNA-sequencing to characterize the transcriptome from the fetal (chorioallantois) and maternal (endometrium) components of the placenta from mares throughout gestation (4, 6, 10, 11 m). more...

Organism:: Equus caballus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24409
15 Samples

Download data: XLSX

Series

Accession:: GSE136691

ID:: 200136691

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005366913.

Fetal transcripts in maternal blood

(Submitter supplied) The discovery of fetal mRNA transcripts in maternal circulation holds great promise for noninvasive prenatal diagnosis. To identify potential fetal biomarkers, we studied whole blood and plasma transcripts common to term pregnant women and their newborns but reduced or absent in the postpartum mothers. In whole blood, 157 potentially-fetal transcripts were identified. RT-PCR confirmed the presence of specific transcripts, SNP analysis confirmed the presence of fetal transcripts in maternal circulation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
46 Samples

Download data: CEL

Series

Accession:: GSE53669

ID:: 200053669

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001179814.

Effects of Prenatal Tobacco Exposure on Gene Expression Profiling in Umbilical Cord Tissue

(Submitter supplied) Maternal smoking doubles the risk of delivering a low birth weight infant. The purpose of this study was to analyze differential gene expression in umbilical cord tissue as a function of maternal smoking, with an emphasis on growth-related genes. We recruited 15 pregnant smokers and 15 women who never smoked during pregnancy to participate RNA was isolated from umbilical cord tissue collected and snap frozen at the time of delivery. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
30 Samples

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Series

Accession:: GSE11798

ID:: 200011798

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002068615.

Whole Blood Cell Gene Expression Profiling in Patients with Coronary Artery Disease (Homo sapiens)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
393 Samples

Download data: TXT

Series

Accession:: GSE20686

ID:: 200020686

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002068116.

Whole Blood Cell Gene Expression Profiling in Patients with Coronary Artery Disease from the PREDICT Trial

(Submitter supplied) Expression profiling of whole blood cells isolated from patients piror to undergoing cardiac catheterization. PREDICT is a prospective, multi-center coronary catheter-lab trial being run in the US for the purpose of identifying biomarkers associated with coronary disease. A summary of the trial can be found at http://clinicaltrials.gov (identifier # NCT00500617).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
198 Samples

Download data: TXT

Series

Accession:: GSE20681

ID:: 200020681

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002068017.

Whole Blood Cell Gene Expression Profiling in Patients with Coronary Artery Disease from the Cathgen Registry

(Submitter supplied) Expression profiling of whole blood cells isolated from patients piror to undergoing cardiac catheterization. The Cathgen Registry is a single-center coronary catheter-lab cohort being run at Duke University for the purpose of identifying biomarkers associated with coronary disease.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
195 Samples

Download data: TXT

Series

Accession:: GSE20680

ID:: 200020680

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000480618.

Gene expression profiles of T-lymphocytes are sensitive to the influence of heavy smoking

(Submitter supplied) Cigarette smoke components have a proven negative influence on human health. Adverse metabolic effects have been observed in tissues and single cells. As T-lymphocytes get in contact with affected organs (e.g. lung) or cells (e.g.erythrocytes), as well as with smoke components and bioactive molecules, whose production is influenced by them, we compared the gene exression profiles in these cells of the adaptive immune system of three male heavy smokers and three male non-smokers We combined rapid immuno-precipitation and Affymetrix GeneChip® HG U133A2.0 microarray analysis to analyse the data set. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2563
Platform:: GPL571
6 Samples

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Series

Accession:: GSE4806

ID:: 200004806

Select item 256319.

Cigarette smoking effect on T lymphocytes

Analysis of T lymphocytes of 3 male heavy smokers. Results provide insight into sensitivity of T lymphocytes to cigarette smoking.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 specimen sets

Platform:: GPL571
Series:: GSE4806
5 Samples

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DataSet

Accession:: GDS2563

ID:: 2563

Select item 20015172820.

Intrauterine inflammation-induced transcriptome changes in the mouse placenta

(Submitter supplied) Placental insufficiency is implicated in the intrauterine infection-associated spontaneous preterm birth. Using a mouse model of LPS-induced intrauterine inflammation that leads to preterm delivery, RNA-seq study was performed in the placenta at gestational day 17 to assess the transcriptome changes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
16 Samples

Download data: TXT

Series

Accession:: GSE151728

ID:: 200151728

PubMed Full text in PMC Similar studies SRA Run Selector

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