GEO DataSets

Analysis of gonadotrope/null cell tumors and normal pituitaries from autopsy samples. Pituitary gonadotrope tumors cause significant morbidity, hormonal deficits, and are more common in men. Results provide insight into molecular mechanisms involved in pituitary tumorigenesis and progression.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 2 gender sets

Platform:

GPL570

Series:

GSE26966

23 Samples

Download data: CEL

(Submitter supplied) Gonadotrope or null cell pituitary tumors present clinically with signs of hypogonadism and hypopituitarism, together with visual disturbances due to mass effects. Since there are no medical therapies, surgery and/or radiation are the only therapeutic options. To identify dysregulated genes and/or pathways that may play a role in tumorigenesis and/ or progression, molecular profiling was performed on 14 gonadotrope tumors and 9 normal human pituitaries from autopsy samples. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4275

Platform:

GPL570

23 Samples

Download data: CEL

(Submitter supplied) Proper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for reproduction. We performed RNAseq of 3 maturaton staged gonadotrope cell lines, a thyroptrope cell line and NIH-3T3 cells to establish the timing and expression levels of genes involved in gonadotrope maturation.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

5 Samples

Download data: XLSX

(Submitter supplied) An Affymetrix Human Gene 1.1 ST array plate (Thermo Fisher Scientific) was hybridized with 2.3 µg of fragmented and labeled single-stranded complementary DNA (cDNA)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

41 Samples

Download data: CEL