GEO DataSets

Analysis of left ventricular heart from donors with no previous history of heart disease. Results provide insight into associations between 9p21.3 (rs1333049) genotype and transcripts in cardiovascular tissue.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL6244

Series:

GSE22253

108 Samples

Download data: CEL

(Submitter supplied) Genome-wide association studies have identified a small region at chromosome 9p21.3 strongly associated with coronary heart disease risk. The region contains no protein-coding genes and the mechanism underlying its association with heart disease is unknown. We investigated associations between rs1333049, a single nucleotide polymorphism representing the 9p21.3 locus, and levels of cardiac gene expression in myocardial tissue from donors with no documented history of heart disease.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4318

Platform:

GPL6244

108 Samples

Download data: CEL, ZIP

(Submitter supplied) Sex-differences in human liver gene expression were characterized on a genome-wide scale using a large liver sample collection, allowing for detection of small expression differences with high statistical power. 1,249 sex-biased genes were identified, 70% showing higher expression in females. Chromosomal bias was apparent, with female-biased genes enriched on chrX and male-biased genes enriched on chrY and chr19, where 11 male-biased zinc-finger KRAB-repressor domain genes are distributed in six clusters. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

16 Samples

Download data: TXT

(Submitter supplied) Gene expression in peripheral blood is shown sufficient to differentiate patients with metabolic disorders from control. The signatures of metabolic syndrome, coronary artery disease and type 2 diabetes also have significant overlap.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10775

35 Samples

Download data: GPR

(Submitter supplied) Smooth muscle cells (SMCs) go through pehnotypic transition during atherosclerosis progression. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of SMCs in aorta tissuee.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

26 Samples

Download data: TAR

(Submitter supplied) Gene expression studies are used to help identify disease-associated genes, by comparing the levels of expressed transcripts between cases and controls, and to identify functional genetic variants known as expression quantitative loci (eQTLs). While many of these studies are performed in blood or lymphoblastoid cell lines due to tissue accessibility, the relevance of expression differences in tissues that are not the primary site of disease is unclear. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

29 Samples

Download data: CEL

(Submitter supplied) Whole peripheral blood samples collected into Paxgene tubes from 338 adult participants in the Emory University Cardiovascular Biobank, in Midtown Atlanta. The sample is of mixed cardiovascular function diversity, and is part of a survey of the impact of status of cardiovascular disease on gene expression and clinical attributes. Sample annotations only include gender and proofed ethnicity for purposes of IRB, as well as technical features of the study (plate, phase of study, and RNA quality RIN score).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

338 Samples

Download data: TXT