Similar studies for GEO DataSets (Select 4336) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 43361.

Pancreatic ductal adenocarcinoma tumor and adjacent non-tumor tissue

Analysis of 45 matching pairs of pancreatic ductal adenocarcinoma (PDAC) tumor and adjacent non-tumor tissue. Results provide insight into tumor markers with prognostic significance and molecular mechanisms underlying PDAC.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 disease state, 45 individual, 2 tissue sets

Platform:: GPL6244
Series:: GSE28735
90 Samples

Download data: CEL

DataSet

Accession:: GDS4336

ID:: 4336

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000287352.

Microarray gene-expression profiles of 45 matching pairs of pancreatic tumor and adjacent non-tumor tissues from 45 patients with pancreatic ductal adenocarcinoma

(Submitter supplied) In order to identify biologically relevant tumor markers with prognostic significance, we set out to analyze gene expression profiling of tumor and adjacent non-tumor tissues from PDAC cases. We compared the microarray gene-expression profiles of 45 matching pairs of pancreatic tumor and adjacent non-tumor tissues. This data set were used to obtained genes that were differentially expressed and associated with survival. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4336
Platform:: GPL6244
90 Samples

Download data: CEL

Series

Accession:: GSE28735

ID:: 200028735

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000611663.

Global mRNA/LncRNA expression analysis of pancreatic tumors causing type3C Diabetes Mellitus

(Submitter supplied) Pancreatic tumors with small size can cause type3C Diabetes Mellitus (PCA-DM) but the mechanism is unknown. In this study we aimed at revealing the mRNA and long noncoding RNA (LncRNA) expression patterns of pancreatic tumors that triggered PCA-DM. Four pancreatic tumors from patients with PCA-DM (A1-A4), four pancreatic tumors from patients without PCA-DM (B1-B4), and four pancreatic tissues from patients with pancreatitis were individually profiled with Agilent microarrays(Arraystar Human LncRNA Array v3.0).

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platform:: GPL16956
12 Samples

Download data: TXT

Series

Accession:: GSE61166

ID:: 200061166

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000782294.

Microarray gene-expression profiles of 50 pancreatic tumors tissue from patients with pancreatic ductal adenocarcinoma

(Submitter supplied) In order to identify biologically relevant tumor markers, and novel therapeutic target we have compared the tumor gene expression profiles of long (OS>=24 months,n=14) and short (OS <=7months, n=11) survival patients. Then we conducted Kaplan-Meier survival analysis using all the 50 samples listed here. The Affymetrix gene-expression data of these 50 samples were also included in the earlier submission by us as GEO accession number GSE62452.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
50 Samples

Download data: CEL

Series

Accession:: GSE78229

ID:: 200078229

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000806165.

microRNA Expression profiles of parental Panc1 cell lines and Gemcitabine resistance Panc1 cell lines

(Submitter supplied) Gemcitabine (GEM) is a key drug for treating PDAC, and it is commonly used for adjuvant chemotherapy. Although the majority of PDAC is sensitive to GEM at first, GEM cannot control PDAC for very long, suggesting that PDAC develops resistance to GEM after prolonged exposure. No reliable predictors of susceptibility to gemcitabine chemotherapy exist in pancreatic ductal adenocarcinoma. MicroRNAs (miR) are epigenetic gene regulators with tumorsuppressive or oncogenic roles in various carcinomas. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15446
4 Samples

Download data: TXT

Series

Accession:: GSE80616

ID:: 200080616

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000624986.

microRNA Expression Profiling of MIF-high and MIF-low Pancreatic Ductal Adenocarcinoma using Nanostring nCounter Platform

(Submitter supplied) We identified differentially expressed microRNAs between MIF-high and MIF-low tumor groups. These microRNAs were then investigated for their potential downstream targets using an integrative strategy, which combines miR-Walk target prediction module and mRNA expression array data to identify key MIF-induced signalling pathways driving tumor progresion and disease aggressiveness. Genes that associated with prognostic significance was then subjected to mechanistic study.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL16142
69 Samples

Download data: RCC, TXT

Series

Accession:: GSE62498

ID:: 200062498

PubMed Full text in PMC Similar studies

Select item 2000624527.

Microarray gene-expression profiles of 69 pancreatic tumors and 61 adjacent non-tumor tissue from patients with pancreatic ductal adenocarcinoma

(Submitter supplied) In order to identify biologically relevant tumor markers , we analyzed gene expression profiling of tumor and adjacent non-tumor tissues from PDAC cases. We compared the microarray gene-expression profiles of MIF-high and MIF low expressing tumors as detrmined by qRT-PCR. Affymetrix gene-expression analysis was done in two sets. Affymetrix data from sample number 1-90 were earlier submited by us as GEO accession#: GSE28735. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
130 Samples

Download data: CEL, XLSX

Series

Accession:: GSE62452

ID:: 200062452

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000789828.

Expression data from gemcitabine treated pancreatic CAFs

(Submitter supplied) Pancreatic ductal adenocarcinoma (PDAC) has a characteristically dense stroma comprised predominantly of cancer associated fibroblasts (CAFs). CAFs promote tumor growth, metastasis and treatment resistance. We aimed to investigate the molecular changes and functional consequences associated with chemotherapy treatment of PDAC CAFs. Chemoresistant immortalized CAFs (R-CAFs) were generated by continuous incubation in 100nM gemcitabine. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE78982

ID:: 200078982

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001585419.

Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24676 GPL18573
39 Samples

Download data

Series

Accession:: GSE158541

ID:: 200158541

PubMed Full text in PMC Similar studies

Select item 20015854010.

Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition [ChIP-seq]

(Submitter supplied) We performed ChIP-seq ananlysis on HDAC1 in MiaPaCa2 using two different antibodies (Santa Cruz Biotechnologies sc-81598 HDAC1(10E2) and Invitrogen HDAC1 Polyclonal Antibody PA1-860), two non-targeting scrableled sgRNA controls and two replicates for each.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
10 Samples

Download data: BED

Series

Accession:: GSE158540

ID:: 200158540

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015709611.

Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition [RNA-Seq]

(Submitter supplied) Over expression of co-repressor complexes implicated as a cause of multiple drug resistance in pancreatic cancer.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
29 Samples

Download data: CSV

Series

Accession:: GSE157096

ID:: 200157096

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20013159612.

RNA-sequencing of Panc-1 cells with ABCG2 over-expression

(Submitter supplied) The goal of this study was to determine whether the selected sgRNAs increases expression of ABCG2 and whether there are other significant off-target effects

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
4 Samples

Download data: XLSX

Series

Accession:: GSE131596

ID:: 200131596

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20002150113.

A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma

(Submitter supplied) A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma (PDAC), comprising over 90% of all pancreatic cancers, remains a lethal disease with an estimated 232,000 new cases, 227,000 deaths per year worldwide, and a less than 5% five-year survival rate. Currently the standard of care for the 20% of patients with localized disease is surgery followed by chemotherapy, and in some cases radiation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
132 Samples

Download data

Series

Accession:: GSE21501

ID:: 200021501

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007457414.

microRNA screening in human pancreatic adenocarcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; synthetic construct

Type:: Non-coding RNA profiling by array

Platforms:: GPL14613 GPL16384
20 Samples

Download data: CEL

Series

Accession:: GSE74574

ID:: 200074574

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007456515.

MicroRNA screening in human pancreatic carcinoma cell lines

(Submitter supplied) No reliable predictors of susceptibility to gemcitabine chemotherapy exist in pancreatic ductal adenocarcinoma. MicroRNAs (miR) are epigenetic gene regulators with tumorsuppressive or oncogenic roles in various carcinomas. This study assesses chemoresistant PDAC for its specific miR expression pattern. Gemcitabine-resistant variants of two mutant p53 human pancreatic adenocarcinoma cell lines were established. more...

Organism:: Homo sapiens; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL16384
12 Samples

Download data: CEL

Series

Accession:: GSE74565

ID:: 200074565

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007456216.

In vitro microRNA screening in human pancreatic adenocarcinoma

(Submitter supplied) No reliable predictors of susceptibility to gemcitabine chemotherapy exist in pancreatic ductal adenocarcinoma. MicroRNAs (miR) are epigenetic gene regulators with tumorsuppressive or oncogenic roles in various carcinomas. This study assesses chemoresistant PDAC for its specific miR expression pattern. Gemcitabine-resistant variants of PANC-1, a mutant p53 human pancreatic adenocarcinoma cell line, were established. more...

Organism:: Homo sapiens; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL14613
8 Samples

Download data: CEL

Series

Accession:: GSE74562

ID:: 200074562

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003878117.

High-throughput microRNA (miRNAs) arrays in pancreatic cancer

(Submitter supplied) Background: Only a subset of radically-resected pancreatic ductal adenocarcinoma (PDAC) patients benefit from chemotherapy, and identification of novel prognostic factors is warranted. Recently miRNAs emerged as diagnostic biomarkers and innovative therapeutic targets, while high-throughput arrays are opening new opportunities to evaluate whether they can also predict clinical outcome. The present study evaluated whether comprehensive miRNA expression profiling correlated with overall survival (OS) in resected PDAC patients. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL14903
19 Samples

Download data: TXT

Series

Accession:: GSE38781

ID:: 200038781

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002144018.

Gene expression analysis of pancreatic cancer associated fibroblasts

(Submitter supplied) Gene expression analysis of pancreatic cancer associated fibroblasts and control fibroblasts To identify signaling pathways important in tumor-stromal cell interactions, we performed gene expression profiling on pancreatic cancer associated fibroblast cultures and control fibroblast cultures using Affymetrix Exon arrays.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5188
12 Samples

Download data: CEL

Series

Accession:: GSE21440

ID:: 200021440

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010508319.

Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule

(Submitter supplied) Human pancreatic ductal adenocarcinoma (PDAC) involves the dysregulation of multiple signalling pathways. A novel approach to the treatment of PDAC is described, involving the targeting of cancer genes in PDAC pathways having over-representation of G-quadruplexes, using the quadruplex-binding compound CM03. This has been designed by computer modelling, is a potent inhibitor of cell growth in PDAC cell lines and has anti-cancer activity in PDAC models, with a superior profile compared to gemcitabine, a commonly used therapy. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
104 Samples

Download data: TXT

Series

Accession:: GSE105083

ID:: 200105083

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20022712920.

PRMT1 Promotes Epigenetic Reprogramming Associated with Acquired Chemoresistance in Pancreatic Cancer

(Submitter supplied) Pancreatic Ductal Adenocarcinoma (PDAC) is associated with extremely poor prognosis due to late diagnosis and therapeutic resistance. Here we show that PDAC cells undergo progressive reprogramming of the global epigenetic landscape during the process of acquiring chemoresistance. Through an epigenetic inhibitor screen, we identified Protein Arginine methyltransferase 1 (PRMT1) as a central driver of chemoresistance in PDAC. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
29 Samples

Download data: BW

Series

Accession:: GSE227129

ID:: 200227129

PubMed Full text in PMC Similar studies

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Links from GEO DataSets

Items: 20

Send to:

Supplemental Content

Find related data

Important Links

Recent activity