GEO DataSets

Analysis of primary or metastatic lesions from patients with unresectable colorectal cancer (CRC) prior to FOLFOX6 therapy (oxaliplatin, 5-fluorouracil, leucovorin regimen). Results provide insight into molecular signatures that predict responders to FOLFOX therapy for unresectable CRC.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 individual, 2 specimen sets

Platform:

GPL570

Series:

GSE28702

54 Samples

Download data: CEL

(Submitter supplied) The aim of this study is to identify responders to FOLFOX therapy by applying the Random Forests (RF) algorithm to gene expression data. Eighty-three unresectable colorectal cancer (CRC) patients including 42 responders and 41 non-responders were divided into training (54 patients) and test (29 patients) sets.

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4393 GDS4396

Platform:

GPL570

83 Samples

Download data: CEL

Analysis of primary or metastatic lesions from patients with unresectable colorectal cancer (CRC) prior to FOLFOX6 therapy (oxaliplatin, 5-fluorouracil, leucovorin regimen). Results provide insight into molecular signatures that predict responders to FOLFOX therapy for unresectable CRC.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 individual, 2 specimen sets

Platform:

GPL570

Series:

GSE28702

29 Samples

Download data: CEL

(Submitter supplied) Samples were taken from colorectal cancers in surgically resected specimens in 189 colorectal cancer patients. The expression profiles were determined using Affymetrix Human Genome U133 Plus 2.0 arrays. Comparison between the sample groups allow to identify a set of discriminating genes that can be used for molecular markers for predicting liver metastasis. Keywords: repeat

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

189 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

114 Samples

Download data: CEL

(Submitter supplied) To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. We then validated the identified genes using data obtained by different groups. The 33-gene signature was able to classify 87% of hepatic metastases, 98% of primary tumors, 97% of normal colon mucosa, and 95% of normal liver tissues in six datasets obtained using five different microarray platforms. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL97

57 Samples

Download data: CEL

(Submitter supplied) In patients with advanced colorectal cancer, leucovorin, fluorouracil, and irinotecan (FOLFIRI) is considered as one of the reference first-line treatments. However, only about half of treated patients respond to this regimen, and there is no clinically useful marker that predicts response. A major clinical challenge is to identify the subset of patients who could benefit from this chemotherapy. We aimed to identify a gene expression profile in primary colon cancer tissue that could predict chemotherapy response. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

21 Samples

Download data: CEL

(Submitter supplied) To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. We then validated the identified genes using data obtained by different groups. The 33-gene signature was able to classify 87% of hepatic metastases, 98% of primary tumors, 97% of normal colon mucosa, and 95% of normal liver tissues in six datasets obtained using five different microarray platforms. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

57 Samples

Download data: CEL