Similar studies for GEO DataSets (Select 4602) - GEO DataSets

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Items: 20

Select item 46021.

Psoriasis lesional and non-lesional skin

Analysis of skin punch biopsies from lesional skin (involved sample) and non-lesional skin (uninvolved sample) from each psoriatic patient. Psoriasis is an immune-mediated, inflammatory and hyperproliferative disease of skin and joints. Results provide insight into the molecular basis of psoriasis.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state, 3 specimen sets

Platform:: GPL570
Series:: GSE13355
180 Samples

Download data: CEL

DataSet

Accession:: GDS4602

ID:: 4602

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000276282.

Expression data from affected skin from psoriasis mouse models and normal skin from control mice

(Submitter supplied) Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse models have been proposed, no single model recapitulates all features of the human disease, and standardized validation criteria for psoriasis mouse models have not been widely applied. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3907
Platform:: GPL1261
34 Samples

Download data: CEL

Series

Accession:: GSE27628

ID:: 200027628

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Select item 2000133553.

Gene expression data of skin from psoriatic patients and normal controls

(Submitter supplied) Gene expression has been proposed as an intermediate phenotype that can increase power in complex trait gene-mapping studies. Psoriasis, an immune-mediated, inflammatory and hyperproliferative disease of the skin and joints, provides an ideal model system to evaluate this paradigm, as conclusive evidence demonstrates that psoriasis has a genetic basis and the disease tissue is readily accessible. To better understand the complex nature of processes in psoriasis, we characterize gene expression profiles in uninvolved and involved skin from affected individuals as well as normal skin from control individuals. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4602
Platform:: GPL570
180 Samples

Download data: CEL

Series

Accession:: GSE13355

ID:: 200013355

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 39074.

Psoriasis mouse models

Analysis of psoriatic skin from back, ear from five psoriasis models (K5-Tie2, imiquimod, K14-AREG, K5-Stat3C and K5-TGFbeta1). Psoriasis is a chronic autoimmune disease characterized by patches of red, often scaly skin. Results provide insight into molecular mechanisms underlying psoriasis.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 disease state, 10 genotype/variation, 5 strain, 3 tissue sets

Platform:: GPL1261
Series:: GSE27628
34 Samples

Download data: CEL

DataSet

Accession:: GDS3907

ID:: 3907

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000368685.

Simvastatin treated Lymphoblastoid Cell lines from Cholesterol and Pharmacogenomics (CAP) Trial

(Submitter supplied) Statins reduce cardiovascular disease risk by lowering plasma low density lipoprotein (LDL)-cholesterol. To identify novel pathways that modulate statin response, we assessed the influence of simvastatin exposure on expression quantitative trait locus (eQTL) associations across the genome in 480 lymphoblastoid cell lines (LCLs). Cell lines were derived blood samples collected ant entry visit from participants in the Cholesterol and Pharmacogenomics (CAP) trial, who underwent a 6 week 40mg/day simvastatin trial. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6883
960 Samples

Download data: TXT

Series

Accession:: GSE36868

ID:: 200036868

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Select item 2000288936.

Genetic identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue [Illumina Expression Array]

(Submitter supplied) Most loci identified in genome wide association studies (GWAS) of complex traits reside in non-coding DNA and may contribute to phenotype via changes in gene regulation. The discovery of expression quantitative trait loci (?eQTLs?) can thus be used to more precisely identify modest but real disease associations and provide insights into their underlying molecular mechanisms. This is particularly true for analyses of expression in non-transformed cells from tissues relevant to the complex traits of interest. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6104
60 Samples

Download data: TXT

Series

Accession:: GSE28893

ID:: 200028893

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Select item 2000261067.

Genetic identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; SNP genotyping by SNP array; Genome variation profiling by SNP array

Platforms:: GPL4133 GPL8887 GPL6104
748 Samples

Download data: TXT

Series

Accession:: GSE26106

ID:: 200026106

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Select item 2000261058.

Genetic identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue [Illumina SNP array]

(Submitter supplied) Most loci identified in genome wide association studies (GWAS) of complex traits reside in non-coding DNA and may contribute to phenotype via changes in gene regulation. The discovery of expression quantitative trait loci (‘eQTLs’) can thus be used to more precisely identify modest but real disease associations and provide insights into their underlying molecular mechanisms. This is particularly true for analyses of expression in non-transformed cells from tissues relevant to the complex traits of interest. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:: GPL8887
224 Samples

Download data: TXT

Series

Accession:: GSE26105

ID:: 200026105

PubMed Full text in PMC Similar studies

Select item 2000259359.

Genetic identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue [Agilent]

(Submitter supplied) Most loci identified in genome wide association studies (GWAS) of complex traits reside in non-coding DNA and may contribute to phenotype via changes in gene regulation. The discovery of expression quantitative trait loci (‘eQTLs’) can thus be used to more precisely identify modest but real disease associations and provide insights into their underlying molecular mechanisms. This is particularly true for analyses of expression in non-transformed cells from tissues relevant to the complex traits of interest. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
464 Samples

Download data: TXT

Series

Accession:: GSE25935

ID:: 200025935

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Select item 20005823910.

Allele-specific expression and eQTL analysis in mouse adipose tissue

(Submitter supplied) In this study we use RNAseq to explore allele specific expression (ASE) in adipose tissue of male and female F1 mice, produced from reciprocal crosses of C57BL/6J and DBA/2J strains. Comparison of the identified cis-eQTLs, to local-eQTLs, that were obtained from adipose tissue expression in two previous population based studies in our laboratory, yields poor overlap between the two mapping approaches, while both local-eQTL studies show highly concordant results. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE58239

ID:: 200058239

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003638111.

Rare and common variants in CARD14, an epidermal regulator of NF-kappaB, in psoriasis

(Submitter supplied) Psoriasis is a common inflammatory disorder of the skin and other organs. We have determined that mutations in CARD14, encoding an NF-kB activator within skin epidermis, account for PSORS2. Here we describe fifteen additional rare, missense variants in CARD14, their distribution in seven psoriasis cohorts (>6,000 cases and >4,000 controls), and their effects on NF-kB activation and the transcriptome of keratinocytes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
17 Samples

Download data: TXT

Series

Accession:: GSE36381

ID:: 200036381

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Select item 20011663812.

Role of AHR in lymphoblastoid cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL20301
54 Samples

Download data: BED

Series

Accession:: GSE116638

ID:: 200116638

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Select item 20011663713.

RNA-seq of eight lymphoblastoid cell lines after AHR ligand treatments

(Submitter supplied) RNA-seq was done on eight different lymphoblastoid cell lines for vehicle control, 3-MC agonist treatment and GNF-351 antagonist treatment for AHR to look at AHR regulated genes with different genetic backgrounds. We identified 69 genes that were highly differentially expressed after 3-MC or GNF-351 antagonist treatment with variation in the degree fo differential expression between the eight cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
48 Samples

Download data: TXT

Series

Accession:: GSE116637

ID:: 200116637

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Select item 20011663214.

AHR ChIP-seq in lymphoblastoid cell line

(Submitter supplied) ChIP-seq was done on one lymphoblastoid cell lines for vehicle control, or 3-MC agonist treatment to identify AHR binding regions throughout the genome. We identified 17,688 common binding peaks between all ChIP treatments

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
6 Samples

Download data: BED

Series

Accession:: GSE116632

ID:: 200116632

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010177115.

Expression quantitative trait loci of primary melanocytes facilitate identification of melanoma susceptibility genes

(Submitter supplied) eQTL is a powerful method to detect genotype-expression correlation. To be able to identify the genes whose expression levels are correlated with germline genetic variants including the ones associated with melanoma, eQTL analysis was performed in 106 primary melanocyte cultrures

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platform:: GPL22678
124 Samples

Download data: IDAT, TXT

Series

Accession:: GSE101771

ID:: 200101771

PubMed Full text in PMC Similar studies

Select item 20003382816.

Genome-wide analysis of gene expression profiles in the Rotterdam Study III

(Submitter supplied) Gene expression profiles were compared to investigate age-marking differential gene expression.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
881 Samples

Download data: TXT

Series

Accession:: GSE33828

ID:: 200033828

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Select item 20011548417.

Expression data from Microarray experiment in muscle and liver tissues

(Submitter supplied) In the current work we have compared the transcriptomic and eQTL profiles of the porcine skeletal muscle and liver by using a data set of 103 Duroc pigs genotyped with the Illumina SNP60 BeadChip and with available microarray measurements of gene expression for both tissues.

Organism:: Sus scrofa

Type:: Expression profiling by array

Platform:: GPL3533
206 Samples

Download data: CEL

Series

Accession:: GSE115484

ID:: 200115484

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Select item 20014661518.

Mendelian randomization identifies FLCN expression as a mediator of diabetic retinopathy

(Submitter supplied) The goal of the study was to identify genes whose aberrant expression can contribute to diabetic retinopathy. We determined differential response in gene expression to high glucose in lymphoblastoid cell lines derived from matched type 1 diabetic individuals with and without retinopathy. Those genes exhibiting the largest difference in glucose response between diabetic subjects with and without retinopathy were assessed for association to diabetic retinopathy utilizing genotype data from a meta-genome-wide association study. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
144 Samples

Download data: IDAT, TXT

Series

Accession:: GSE146615

ID:: 200146615

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Select item 20007534319.

Molecular and cellular profilling of scalp psoriasis reveals differences and similarities compared to skin psoriasis

(Submitter supplied) Scalp psoriasis shows a variable clinical spectrum and in many cases poses a great therapeutic challenge. However, it remains unknown whether the immune response of scalp psoriasis differs from understood pathomechanisms of psoriasis on other skin areas. We sought to determine the cellular and mollecular phenotype of scalp psoriasis by performing a comparative analysis of scalp vs skin using lesional and nonlesional samples from 20 Caucasian subjects with untreated moderate to severe psoriasis and significant scalp involvement, and 10 control subjects without psoriasis. more...