GEO DataSets

Analysis of memory and non-memory cells sorted from MD12/p53R2-RE cells 3 days after UV-induced DNA damage. Cells in a population respond heterogeneously to DNA damage. Results provide insight into heritable memory of DNA damage existing in subpopulations that differ in long-term cell behavior.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell type, 2 genotype/variation, 2 stress sets

Platform:

GPL6244

Series:

GSE38189

8 Samples

Download data: CEL

(Submitter supplied) Cells respond heterogeneously to DNA damage. We engineered genetic circuits to detect differential responses in a population that persist for many days post-stimulus. We used microarrays to compare memory and non-memory subpopulations 3 days after DNA damage or doxycycline exposure.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4610

Platform:

GPL6244

8 Samples

Download data: CEL

(Submitter supplied) Differential responses to stimuli can affect how cells succumb to disease. In yeast, DNA damage can create heterogeneous responses. To delineate how a response contributes to a cell's future behavior, we constructed a transcription-based memory circuit that detects DNA repair to isolate subpopulations with heritable damage responses. Strongly responsive cells show multigenerational effects, including growth defects and iron-associated gene expression. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL15292

3 Samples

Download data: TXT

(Submitter supplied) Gene expression analysis in human bronchial epithelial cells expressing wild type EGFR or activating mutations, L858R or E7646-E750 EGFR in a normoxic environment (21% oxygen) or at 24 hours of exposure to a hypoxic environment (0.1% oxygen). The effect of EGFR mutations on base-line and hypoxia-induced gene expression was determined.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

12 Samples

Download data: TXT