GEO DataSets

Analysis of venous endothelial cells (EC) following experimental venous hypertension treatment, a venous stress test designed to model peripheral venous congestion. Results provide insight into the molecular consequences of peripheral acute venous congestion in ECs.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 12 individual, 2 protocol sets

Platform:

GPL570

Series:

GSE38783

24 Samples

Download data: CEL

(Submitter supplied) Background: Venous hypertension is often present in advanced and in acute decompensated heart failure (HF). However, it is unclear whether high intravenous pressure can cause alterations in homeostasis by promoting inflammation and endothelial cell (EC) activation. We used an experimental model of acute, local venous hypertension to study the changes in circulating inflammatory mediators and EC phenotype that occur in response to biomechanical stress. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4773

Platform:

GPL570

24 Samples

Download data: CEL

(Submitter supplied) Two matched groups of Heart Failure with reduced ejection fraction patients with no peripheral venous congestion were studied: with recent prior heart failure hospitalization vs. without recent heart failure hospitalization. Peripheral venous congestion was modeled by inflating a cuff around the dominant arm, targeting an ~30mmHg increase in venous pressure (venous stress test). Blood and endothelial cells were sampled before and after 90 minutes of venous stress test.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL570

46 Samples

Download data: CEL

(Submitter supplied) Obesity is characterized by a chronic auto-inflammation of the hypertrophied white adipose tissue (WAT) associated with metabolic and vascular complications. WAT of obese subjects produces inflammatory factors like cytokines (IL6, TNF-alpha) and chemokines (CCL2 and IL-8) originating mainly from the accumulated macrophages. WAT macrophages profoundly affect adipose cell biology leading in particular to the inflammation of the adipocytes and altered differentiation of their precursors, the pre-adipocytes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13379

5 Samples

Download data: GPR

(Submitter supplied) Right ventricular failure was induced thourgh pulmonary banding in 11 pigs. Right ventricular failure was defined as a SRVP >50 mmHg during two hours. After right ventricular failure was induced, half the pigs were treated with a Glenn-shunt combined with pulmonary banding for one hour, and the other half served as control group with pulmonary banding only. The aim was to study the change in global gene expression during right ventricular failure due to pulmonary banding, and the effect of volume unloading during pulmonary banding.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

33 Samples

Download data: CEL

(Submitter supplied) Interleukin-17 (IL-17)-secreting T helper 17 cells (Th17) are a recently identified CD4+ T helper subset that has been implicated in various inflammatory and autoimmune diseases. The issue of whether interleukin-17A (IL-17) contributes to hyperlipidemia-induced aortic endothelial cell activation remained unknown. Here, we reported that IL-17 contributes to hyperlipidemia-induced modulation of vascular cell gene expression during early atherosclerosis in vivo. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

10 Samples

Download data: CEL