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Links from GEO DataSets

Items: 3

1.
Full record GDS4834

Colistin effect on the kidney

Analysis of kidneys from C57BL/6J males following treatment with colistin. Colistin is an antibiotic prescribed for multidrug resistant gram negative bacterial infections. It is associated with nephrotoxicity. Results provide insight into the molecular basis of colistin nephrotoxicity.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL6887
Series:
GSE46410
12 Samples
Download data
2.

Differential gene expression in mouse kidney following 72 hours of colistin exposure by Illumina WG-6_V2 array

(Submitter supplied) Colistin sulfate (polymixin E) is an antibiotic prescribed with resurging frequency for multidrug resistant gram negative bacterial infections. It is associated with nephrotoxicity in humans in up to 33% of cases. Little is known regarding genes involved in colistin nephrotoxicity. A murine model of colistin-mediated kidney injury was developed. C57/BL6 mice were administered saline or colistin at a dose of 16mg/kg/day in 2 divided doses. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4834
Platform:
GPL6887
12 Samples
Download data: TXT
Series
Accession:
GSE46410
ID:
200046410
3.

Expression data from the kidney of Sprague-Dawley rats given colistin methanesulfonate sodium

(Submitter supplied) To investigate the mechanism of nephrotoxicity, colistin methanesulfonate sodium (CMS; 25 or 50 mg/kg) was administered via intraperitoneal injection to Sprague–Dawley rats daily over 7 d. Affymetrix GeneChip microarrays indicated 894 differentially expressed genes in groups treated with CMS (ANOVA, FDR < 0.05, fold change ≥ 1.3).
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
9 Samples
Download data: CEL, CHP
Series
Accession:
GSE121792
ID:
200121792
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