Similar studies for GEO DataSets (Select 4845) - GEO DataSets

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Items: 17

Select item 48451.

Streptozotocin induced type 1 diabetes: liver

Analysis of liver from C57BL/6N males treated with streptozotocin (STZ) to induce type 1 diabetes (T1D). Liver mitochondria of STZ males showed increased oxygen consumption. Results provide insight into molecular mechanisms underlying the enhanced performance of T1D STZ liver mitochondria.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent sets

Platform:: GPL6246
Series:: GSE39752
13 Samples

Download data: CEL

DataSet

Accession:: GDS4845

ID:: 4845

Select item 2000790082.

Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice

(Submitter supplied) Bezafibrate (BEZ), a pan activator of peroxisome proliferator-activated receptors (PPARs), is generally used to treat hyperlipidemia. Clinical trials on patients suffering from type 2 diabetes indicated that BEZ also has beneficial effects on glucose metabolism, but the underlying mechanisms remain elusive. Much less is known about the function of BEZ in type 1 diabetes. Here, we show that BEZ treatment markedly improves hyperglycemia, glucose and insulin tolerance in streptozotocin (STZ)-treated mice, an insulin-deficient mouse model of type 1 diabetes presenting with very high blood glucose levels. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
5 Samples

Download data: CEL

Series

Accession:: GSE79008

ID:: 200079008

Select item 2000397523.

Liver adapts mitochondrial function to insulin-resistant and diabetic states in mice

(Submitter supplied) Objective: To study if diabetic and insulin-resistant states lead to mitochondrial dysfunction in the liver, or alternatively, if there is adaption of mitochondrial function to these states in the long-term range. Results: High-fat diet (HFD) caused insulin resistance and severe hepatic lipid accumulation, but respiratory chain parameters were unchanged. Livers from insulin-resistant IR/IRS-1+/- mice had normal lipid contents and normal respiratory chain parameters, however showed mitochondrial uncoupling. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4845
Platform:: GPL6246
13 Samples

Download data: CEL

Series

Accession:: GSE39752

ID:: 200039752

Select item 2001797194.

Bezafibrate reduces the elevated hepatic fumarate in insulin-deficient mice.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
35 Samples

Download data: CEL

Series

Accession:: GSE179719

ID:: 200179719

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001797185.

Bezafibrate reduces the elevated hepatic fumarate level in insulin-deficient streptozotocin mice [skeletal muscle tissue]

(Submitter supplied) In addition to high intracellular glucose level, the diabetic state is also characterized by altered metabolites, which are pivotal regulators of glucotoxic pathways. In this study we analyzed Bezafibrate (BEZ) treated Streptozotocin (STZ) mice, which showed improved glucose metabolism compared to untreated STZ controls. In order to identify the key molecules and pathways, which participate in the beneficial effects of BEZ, we analyzed the skeletal muscle, white adipose tissue (WAT) and liver samples of BEZ-treated mice using non-targeted metabolomics (NMR spectroscopy), targeted metabolomics (mass spectrometry), microarrays and enzyme activity measurements with a particular focus on the liver. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
17 Samples

Download data: CEL

Series

Accession:: GSE179718

ID:: 200179718

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Select item 2001797176.

Bezafibrate reduces the elevated hepatic fumarate level in insulin-deficient streptozotocin mice [visceral adipose tissue]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
18 Samples

Download data: CEL

Series

Accession:: GSE179717

ID:: 200179717

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001029827.

JNK activation of BIM promotes hepatic oxidative stress, steatosis and insulin resistance in obesity

(Submitter supplied) The BCL-2 family are crucial regulators of the mitochondrial pathway of apoptosis in normal physiology and disease. Besides their role in cell death, BCL-2 proteins have been implicated in the regulation of mitochondrial oxidative phosphorylation and cellular metabolism. However, it remains unclear whether these proteins have a physiological role in glucose homeostasis and metabolism in vivo. Here we report that fat accumulation in the liver increases JNK-dependent BIM expression in hepatocytes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: GTF

Series

Accession:: GSE102982

ID:: 200102982

PubMed Similar studies SRA Run Selector

Select item 2001529378.

Mouse HFD Liver Skeletal Muscle SLC16A13 Knock-Out

(Submitter supplied) Genome-wide association identified SLC16A13 as novel type 2 diabetes gene locus. The SLC16A13 gene encodes for SLC16A13/MCT13, member of the solute carrier 16 family of monocarboxylate transporters. This transporter family recently raised interest in metabolic research with the identification of SLC16A11 polymorphisms associated with type 2 diabetes; and human as well as mouse data suggest causal relationship between SLC16A11/MCT11 transporter dysfunction and type 2 diabetes development. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
44 Samples

Download data: TXT

Series

Accession:: GSE152937

ID:: 200152937

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000566359.

Gene expression analysis of directly converted brown adipocytes (dBAs).

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL6246 GPL6244
9 Samples

Download data: CEL

Series

Accession:: GSE56635

ID:: 200056635

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005663410.

Gene expression analysis of directly converted brown adipocytes (dBAs). [mouse]

(Submitter supplied) Comparasion of each cell mRNA expression pattern Mouse fibroblasts were directly converted into brown adipocytes (dBAs) by transducing some transcription factors. To characterize the dBAs more in detail, RNA extracted from the mouse brown adipose tissue, mouse dBAs, and mouse iPS-derived brown adipocytes (iBAs) were subjected to DNA microarray analysis, and global gene expression profiles of the cells were compared.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
3 Samples

Download data: CEL

Series

Accession:: GSE56634

ID:: 200056634

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005663311.

Gene expression analysis of directly converted brown adipocytes (dBAs). [human]

(Submitter supplied) Comparasion of each cell mRNA expression pattern Human fibroblasts were directly converted into brown adipocytes (dBAs) by transducing some transcription factors. To characterize the dBAs more in detail, RNA extracted from the human WAs, human dBAs, and human iPS-derived brown adipocytes (iBAs) were subjected to DNA microarray analysis, and global gene expression profiles of the cells were compared.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE56633

ID:: 200056633

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003445112.

Altered gene expression profiles in the hippocampus and prefrontal cortex of type 2 diabetic rats

(Submitter supplied) There has been an incresing body of epidemiologic and biochemical evidence implying the role of cerebral insulin resistance in Alzheimer-type dementia. For a better understanding of the insulin effect on the central nervous system we performed microarray-based gene expression profiling in the hippocampus, striatum and prefrontal cortex of streptozotocin-induced and spontaneously diabetic Goto-Kakizaki rats as model animals for type 1 and type 2 diabetes, respectively. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL15011
27 Samples

Download data: TXT

Series

Accession:: GSE34451

ID:: 200034451

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012649013.

Uncovering the hepatic gene expression variations and sex-differences as response to high-fat diet consumption in the highly genetically diversity of the Collaborative Cross mouse model

(Submitter supplied) Hepatic gene expression variations and sex-differences due to high-fat diet consumption using the Collaborative Cross mouse model

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
84 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE126490

ID:: 200126490

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20020817714.

Effect of aging on mitochondrial gene expression using C57BL/6N liver mitochondria

(Submitter supplied) To investigate the effect of aging on mitochondrial gene expression we isolated liver mitochondria from 4 12-week and 4 65-week C57BL/6N WT mice. We then isolated RNA and prepared the barcoded library using PCR-cDNA Barcoding Kit SQK-PCB109 and ran it on MinIOn R9.4.1 Flow cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24973
8 Samples

Download data: TSV

Series

Accession:: GSE208177

ID:: 200208177

PubMed Full text in PMC Similar studies

Select item 20016202115.

Genetic regulator of mitochondrial metabolism and insulin resistance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL24247
18 Samples

Download data: TXT, WIG

Series

Accession:: GSE162021

ID:: 200162021

PubMed Full text in PMC Similar studies

Select item 20016202016.

Genetic regulator of mitochondrial metabolism and insulin resistance [RNA-Seq]

(Submitter supplied) Mitochondrial energy metabolism and function are key processes underlying the pathophysiology of insulin resistance and predisposition to type 2 diabetes. This is because mitochondria produce most of the energy required by the cell. Impaired energy production, use of energy stores and mitochondrial dysfunction are major features in metabolic diseases. Nevertheless, it remains uncertain how mitochondrial dysfunction can cause, contribute to, or result in insulin resistance and metabolic diseases. more...