Similar studies for GEO DataSets (Select 4904) - GEO DataSets

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Items: 20

Select item 49041.

Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle

Analysis of muscle from aged animals with muscle-specific Pgc-1α depletion. PGC-1alpha is a transcriptional coactivator of the mitochondrial gene program. Results provide insight into the role of Pgc-1α in the glucose intolerance and chronic systemic inflammation associated with aging.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE52550
12 Samples

Download data: CEL

DataSet

Accession:: GDS4904

ID:: 4904

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000525502.

Progressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation

(Submitter supplied) Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4904
Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE52550

ID:: 200052550

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000735723.

The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defense in skeletal muscles

(Submitter supplied) Transcriptional microarray analysis was conducted on gastrocnemius muscle of control and PGC-1β(i)skm-/- mice one week after the last tamoxifen administration using the Affymetrix Mouse Gene 1.0 ST.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE73572

ID:: 200073572

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Select item 2002240424.

Effect of TET3 expression on muscle insulin sensitivity

(Submitter supplied) To gain a mechanistic insight into TET3-mediated regulation of muscle insulin sensitivity, we performed genome-wide expression profiling (RNA-seq) on RNA isolated from GAS muscles of muscle TET3 specific knockdown mice and WT littermates.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: XLSX

Series

Accession:: GSE224042

ID:: 200224042

PubMed Full text in PMC Similar studies

Select item 2000347735.

Skeletal muscle PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction.

(Submitter supplied) Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation and reactive oxygen species scavenging in skeletal muscle and other tissues, and these processes are thought to be critical to the benefits of CR. PGC-1a is a transcriptional coactivator that regulates mitochondrial function and is induced by CR. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
26 Samples

Download data: CEL

Series

Accession:: GSE34773

ID:: 200034773

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000362976.

A PGC-1alpha-dependent decrease in mitochondrial oxidative metabolism in muscle of humans with inherited insulin resistance

(Submitter supplied) We used microarrays to assess gene expression profiling of 6 patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR) and 10 matched healthy controls

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4897
Platform:: GPL571
16 Samples

Download data: CEL

Series

Accession:: GSE36297

ID:: 200036297

Select item 48977.

Skeletal muscle of patients with inherited insulin resistance

Analysis of muscle from patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR). This mutation is associated with inherited insulin resistance. Results provide insight into molecular mechanisms underlying insulin resistance in skeletal muscle.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL571
Series:: GSE36297
16 Samples

Download data: CEL

DataSet

Accession:: GDS4897

ID:: 4897

Select item 2000067668.

C2C12 Myotubes in response to Palmitate

(Submitter supplied) To identify mediators of obesity-linked reductions in PGC-1, we tested the effects of cellular nutrients in C2C12 myotubes. While overnight exposure to high insulin, glucose, glucosamine, or amino acids had no effect, saturated fatty acids (FA) potently reduced PGC-1a and b mRNA expression. Keywords: Nutrient Effect

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2648
Platform:: GPL8321
6 Samples

Download data: CEL

Series

Accession:: GSE6766

ID:: 200006766

Select item 26489.

Palmitate effect on myoblast cell line

Analysis of myoblasts treated with the saturated fatty acid palmitate. Muscle expression of PPAR coactivator 1 (PGC-1) is reduced in models of obesity. Palmitate decreases the expression of PGC-1. Results provide insight into the molecular basis of the link between overnutrition, obesity, and PGC-1.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL8321
Series:: GSE6766
6 Samples

Download data: CEL

DataSet

Accession:: GDS2648

ID:: 2648

Select item 20000549710.

Pyruvate induces mitochondrial biogenesis by a PGC-1alpha independent mechanism

(Submitter supplied) The present study examines the impact of altering energy provision on mitochondrial biogenesis in muscle cells. C2C12 myoblasts were chronically treated with supraphysiological levels of sodium pyruvate for 72 hr. Treated cells exhibited increased mitochondrial protein expression, basal respiratory rate and maximal oxidative capacity. The increase in mitochondrial biogenesis was independent of increases in PGC-1alpha and PGC-1alpha mRNA expression. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2265
Platform:: GPL1261
6 Samples

Download data

Series

Accession:: GSE5497

ID:: 200005497

Select item 226511.

Pyruvate effect on muscle cells

Analysis of C2C12 myoblasts treated with supraphysiological levels of sodium pyruvate for 72 hours. Pyruvate increases mitochondrial biogenesis in muscle myoblasts. Results provide insight into the impact of altering energy provision on mitochondrial biogenesis in muscle cells.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL1261
Series:: GSE5497
6 Samples

Download data

DataSet

Accession:: GDS2265

ID:: 2265

Select item 20005242412.

Gene expression from Prep1-ablated mice

(Submitter supplied) The homeodomain transcription factor Prep1 was previously shown to regulate insulin sensitivity. Our aim was to study the specific role of Prep1 for the regulation of energy metabolism in skeletal muscle. Muscle specific ablation of Prep1 resulted in increased expression of respiratory chain subunits. This finding was consistent with an increase in mitochondrial enzyme activity without affecting mitochondrial volume fraction as assessed by electron microscopy. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
8 Samples

Download data: TXT

Series

Accession:: GSE52424

ID:: 200052424

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010034113.

PGC-1a Provides a Transcriptional Framework for Synchronous Neurotransmitter Release from ParvalbuminPositive Interneurons

(Submitter supplied) PGC-1a is a master regulator for cell mitochondrial and metabolism function. In this experiment neurons were infected with a PGC-1a/GFP adenovirus to examine what genes were upregulated by over expression. Known targets related to mitochondrial health were confirmed while new neuron specific targets were discovered.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6884
6 Samples

Download data: TXT

Series

Accession:: GSE100341

ID:: 200100341

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003734414.

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(Submitter supplied) The study aimed to analyse the transcriptome of mouse cancer cells while in primary tumor, in circulation and after homing to metastatic site. The model used here is the 4T1 cancer cell orthotopic model.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
3 Samples

Download data: TXT

Series

Accession:: GSE37344

ID:: 200037344

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014691915.

Microarray analysis of transgenic mice specifically overexpressing FOXO1 in skeletal muscle (FOXO1 Tg mice)

(Submitter supplied) FOXO1, a member of the FOXO forkhead type transcription factors, is markedly up-regulated in skeletal muscle during atrophy. Previously, we created transgenic mice specifically overexpressing FOXO1 in skeletal muscle (FOXO1 Tg mice). These mice weighed less than the wildtype control mice, had a reduced skeletal muscle mass. In this study, to better understand changes in skeletal muscle during atrophy, we performed a microarray analysis of skeletal muscle in wild-type control and FOXO1 Tg mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
2 Samples

Download data: TXT

Series

Accession:: GSE146919

ID:: 200146919

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Select item 20008026516.

PGC-1a Determines Light Damage Susceptibility of the Murine Retina

(Submitter supplied) The peroxisome proliferator-activated receptor c coactivator 1 (PGC-1) proteins are key regulators of cellular bioenergetics and are accordingly expressed in tissues with a high energetic demand. For example, PGC-1a and PGC-1b control organ function of brown adipose tissue, heart, brain, liver and skeletal muscle. Surprisingly, despite their prominent role in the control of mitochondrial biogenesis and oxidative metabolism, expression and function of the PGC-1 coactivators in the retina, an organ with one of the highest energy demands per tissue weight, are completely unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
13 Samples

Download data: CEL

Series

Accession:: GSE80265

ID:: 200080265

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20021090417.

Fed and fasted skeletal muscle of wildtype and PGC-1beta muscle specific knockout mice

(Submitter supplied) The mechanistic underpinnings of the fasting response in skeletal muscle is still poorly understood. We therefore investigated the role of the transcriptional coactivator PGC-1beta (peroxisome proliferator-activated receptor gamma coactivator 1beta) in this context. To do so, the fasting response in quadriceps muscle was assessed in fed and 24 hours fasted mice and compared between wildtype and PGC-1beta muscle-specific knockout mice (both on a C57Bl6/J background). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
18 Samples

Download data: XLSX

Series

Accession:: GSE210904

ID:: 200210904

PubMed Full text in PMC Similar studies

Select item 20006164318.

PGC-1β Promotes Enterocyte Lifespan and Tumorigenesis in the Intestine

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
30 Samples

Download data

Series

Accession:: GSE61643

ID:: 200061643

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006164219.

Genome-wide analysis expression of ileum tumor samples from FVBN/APCmin and iPGC-1β/APCmin

(Submitter supplied) Analysis of metabolic pathway gene expression. The hypothesis tested in the present study is to assess mRNA level changes in metabolic genes in intestinal tumors from APCmin mice overexpressing PGC-1β specifically in the intestine.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
12 Samples

Download data: TXT

Series

Accession:: GSE61642

ID:: 200061642

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006164120.

Genome-wide analysis expression of ileum samples from wild-type and iPGC-1β

(Submitter supplied) Analysis of metabolic pathway gene expression. The hypothesis tested in the present study is to assess mRNA level changes in metabolic genes in enterocytes from transgenic mice overexpressing PGC-1β specifically in the intestine.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
10 Samples

Download data: TXT

Series

Accession:: GSE61641

ID:: 200061641

PubMed Full text in PMC Similar studies Analyze with GEO2R

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