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Links from GEO DataSets

Items: 4

1.
Full record GDS5009

Neonatal stress and morphine effects on right hippocampus

Analysis of hippocampi of postnatal day 9, C57BL/6 males exposed to mild or severe stress and morphine. Morphine is often prescribed to ameliorate preterm infant pain and stress. Results provide insight into dose-dependent, stress-related changes altered by morphine that may affect neurodevelopment.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 agent, 3 stress sets
Platform:
GPL6246
Series:
GSE50382
15 Samples
Download data: CEL
DataSet
Accession:
GDS5009
ID:
5009

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

2.

Effects of neonatal stress and morphine on murine hippocampal gene expression

(Submitter supplied) Critically ill preterm infants experience multiple stressors while hospitalized. Morphine is commonly prescribed to ameliorate their pain and stress. We hypothesized that neonatal stress will have a dose-dependent effect on hippocampal gene expression, and these effects will be altered by morphine treatment. Male C57BL/6 mice were exposed to 5 treatment conditions between postnatal day 5 and 9: 1) Control, 2) mild stress + saline, 3) mild stress + morphine, 4) severe stress + saline and 5) severe stress + morphine. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5009
Platform:
GPL6246
15 Samples
Download data: CEL
Series
Accession:
GSE50382
ID:
200050382

PubMed Full text in PMC Similar studies Analyze with GEO2R

3.

Neonatal morphine exposure alters mRNA and microRNA (miR) expression in mouse hippocampus

(Submitter supplied) Morphine is used to sedate critically ill infants to treat painful or stressful conditions associated with intensive care. Whether neonatal morphine exposure affects microRNA (miR) expression and thereby alters mRNA regulation is unknown. We tested the hypothesis that repeated morphine treatment in stress-exposed neonatal mice alters hippocampal mRNA and miR gene expression. C57BL/6 male mice were treated from postnatal day (P) 5 to P9 with morphine at 2 or 5 mg/kg ip bid (MS5) and then exposed to stress consisting of hypoxia (100% N2 1 min and 100% O2 5 min) followed by 2h maternal separation. more...
Organism:
Mus musculus; synthetic construct
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platforms:
GPL14613 GPL10787
24 Samples
Download data: CEL, TXT
Series
Accession:
GSE62346
ID:
200062346

PubMed Full text in PMC Similar studies Analyze with GEO2R

4.

microRNA expression and opioid regulation in the zebrafish

(Submitter supplied) We examined morphine responsing miRNAs in Zebrafish embroys. Microarray studies revealed morphine can change microRNA expression in Zebrafish embroys.
Organism:
Caenorhabditis elegans; Drosophila melanogaster; Rattus norvegicus; Danio rerio; Homo sapiens; Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL9517
18 Samples
Download data: TXT
Series
Accession:
GSE18847
ID:
200018847

PubMed Full text in PMC Similar studies Analyze with GEO2R

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