GEO DataSets

Analysis of SUM159 mesenchymal-like breast cancer cells overexpressing miR-203. Result provide insight into the role of miR-203 in epithelial-mesenchymal transition and metastasis in breast cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL570

Series:

GSE50697

6 Samples

Download data: CEL, CHP

(Submitter supplied) Determine the effect of miR-203 expression on the global mRNA expression in mesenchymal breast cancer cell line.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5348

Platform:

GPL570

6 Samples

Download data: CEL, CHP

(Submitter supplied) miRNA expression profiles of HMECs treated with 40mM Jagged1 (JAG1) or the control peptide for 1 day

Organism:

Homo sapiens

Type:

Other

Platform:

GPL18572

2 Samples

Download data: TXT

(Submitter supplied) Using a TWIST1-inducible epithelial-to-mesenchymal transition (EMT) model in HMLE cells, miRNA changes were profiled at different time points during an active EMT.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL18795

12 Samples

Download data: TXT

(Submitter supplied) Epithelial-to-mesenchymal transition (EMT) is a dynamic process that relies on cellular plasticity; an EMT/MET axis is critical for metastatic colonization of carcinomas. Unlike epithelial programming, regulation of mesenchymal programming is not well understood in EMT. Here we describe the first microRNA that enhances exclusively mesenchymal programming. We demonstrate that microRNA-424 is up-regulated early during a TWIST1/SNAI1-induced EMT, and that it causes cells to express mesenchymal genes without affecting epithelial genes, resulting in a mixed/intermediate EMT. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

6 Samples

Download data: TXT

(Submitter supplied) MicroRNAs are critical mediators of stem cell pluripotency, differentiation and malignancy. Limited information exists regarding microRNA alterations that facilitate initiation and progression of human lung cancers. In this study, array techniques were used to evaluate microRNA expression in normal human respiratory epithelia and lung cancer cells cultured in the presence or absence of cigarette smoke condensate (CSC). more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL16382

8 Samples

Download data: TXT

(Submitter supplied) Claudin-low tumors are a highly aggressive breast cancer subtype with no targeted treatments and a clinically documented resistance to chemotherapy. They are significantly enriched in cancer stem cells (CSCs), which makes claudin-low tumor models particularly attractive for studying CSC behavior and developing novel approaches to minimize CSC therapy resistance. One proposed mechanism by which CSCs arise is via an epithelial-mesenchymal transition (EMT), and reversal of this process may provide a potential therapeutic approach for increasing tumor chemosensitivity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11383

7 Samples

Download data

(Submitter supplied) Genome-wide DNA methylation profiles of TGF-beta ovarian cancer cells were obtained using next generation Illumina Infinium 450k assay which includes over 450,000 GpG sites.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

12 Samples

Download data: TXT

(Submitter supplied) We sought to assess how temporary loss of the microtubule-associated protein CRMP2A could affect global gene expression in the A549 lung cancer cells. We used microarrays to identify differentially regulated genes when CRMP2A is temporarily removed from A549 cells using siRNA.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15207

2 Samples

Download data: CEL

(Submitter supplied) We sought to assess how permanent loss of the microtubule-associated protein CRMP2A could affect global gene expression in the A549 lung cancer cells. We used microarrays to identify differentially regulated genes when CRMP2A is permanently removed from A549 cells using CRISPR/Cas9.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15207

2 Samples

Download data: CEL