GEO DataSets

Analysis of prostate cancer (PC) cell lines LNCap (androgen-dependent) and DU145 (androgen-independent) following siRNA-mediated knockdown of Peptidyl-prolyl cis/trans isomerase Pin1. Results provide insight into molecular mechanisms underlying Pin1 modulation of both PC two cell lines.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell line, 3 protocol sets

Platform:

GPL6244

Series:

GSE67457

6 Samples

Download data: CEL

(Submitter supplied) Pin1 inhibiton exerts anti-oncogenic effects on LNCaP and DU145 cells despite the gene regulation patterns by Pin1 were different in both cells. We investigated how Pin1 modulates the gene expressions in the androgen-dependent as well as the androgen-independent prostate cancer cell lines

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5805

Platform:

GPL6244

6 Samples

Download data: CEL, TXT

(Submitter supplied) To investigate the specific gene expression program by which mutant-p53 and Pin1 control invasion and metastasis in breast cancer cells, we compared the transcriptomic profile of control, mutant-p53 depleted or Pin1 depleted MDA-MB-231 cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4070

Platform:

GPL571

9 Samples

Download data: CEL

Analysis of breast cancer cell line MDA-MB-231 depleted of prolyl isomerase Pin1 or mutant-p53. Pin1 overexpression and p53 mutation associate with poor outcome in breast cancer. Results provide insight into the role of a Pin1/mutant p53 axis in the acquisition of aggressive features by tumor cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL571

Series:

GSE26262

9 Samples

Download data: CEL

(Submitter supplied) The protein Glycine-N-Acyltransferase Like 1 (GLYATL1) is involved in detoxification of benzoate and other xenobiotics and is expressed in liver and kidney. Through In silico analysis of cancer gene expression profiling and transcriptome sequencing we revealed an overexpression of GLYATL1 in primary prostate cancer. Confirming these findings by immunohistochemistry we show that GLYATL1 is overexpressed in primary prostate cancer compared to metastatic prostate cancer and benign prostatic tissue. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

4 Samples

Download data: TXT

(Submitter supplied) EVALUATING THE GENE EXPRESSION PROFILE OF PROSTATIC TUMOR CELL IN CO-CULTURE WITH HUMAN ASTROCYTE AND THE TRANSCRIPTIONAL REPROGRAMMING IN ASTROCYTS BY CONTACTING WITH TUMOR CELLS DNA MICROARRAY WAS APPLIED AIMING TO EVALUATE THE GENE EXPRESSION PROFILE

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

14 Samples

Download data: CEL, CHP

(Submitter supplied) We overexpressed the long non-coding RNA GHSROS in the metastatic prostate cancer cell line LNCaP and subcutaneously injected the cells into NOD/SCID mice.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

7 Samples

Download data: TXT

(Submitter supplied) We overexpressed the long non-coding RNA GHSROS in the metastatic prostate cancer cell line PC3.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

6 Samples

Download data: TXT

(Submitter supplied) We profiled the transcriptomes of the dominan nodule (Gleason score 4+5=9) and of the cancer free resection margins of a surgically removed prostate tumor from a 65y old black man. Normalized to the median of valid spots expression data where used to determine the Gene Commanding Height (GCH) Score for every coding and non-coding transcript adequately quantified in all four cancer and four normal tissue samples. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

8 Samples

Download data: TXT

(Submitter supplied) We profiled the transcriptomes of the cancer nucleus (Gleason score 4+5=9) and of the cancer free resection margins of a surgically removed prostate tumor from a 47y old white man. Normalized to the median of valid spots expression data where used to determine the Gene Commanding Height (GCH) Score for every coding and non-coding transcript adequately quantified in all four cancer and four normal tissue samples. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

8 Samples

Download data: TXT

(Submitter supplied) We used Agilent human gene expression arrays to test whether Capridine, a chemotherapeutic agent with specificity towards prostate cancer, deregulates the genomic fabric of acute myeloyd leukemia in HL-60 cells. This cell line was derived at the National Cancer Institute from a 36-year-old woman with acute promyelocytic leukemia. We found that Capridine down-regulates the pathways responsible for formation of hematopoietic progenitor cells, for anti-apoptosis and for proliferation of clonal neoplastic cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

8 Samples

Download data: TXT

(Submitter supplied) Capridine is a chemotherapeutic agent with specificity towards prostate cancer and minimal bone marrow toxicity. Capridine structure is consistent with a classical DNA intercalating agent, although its DNA intercalation property does not fully correlate with its anti prostate cancer specific activity. We have used Agilent human gene expression arrays to identify the cellular targets of Capridine on androgen responsive LNCaP cells, a classical cell lines for prostate cancer studies. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

8 Samples

Download data: TXT

(Submitter supplied) Our preclinical developmental program identified Capridine as a chemotherapeutic agent that had specificity towards prostate cancer with minimal bone marrow toxicity. In human prostate cancer xenograft studies both androgen responsive and non-responsive tumors were inhibited by a weekly therapeutic regimen Capridine. The minimal bone marrow toxicity as seen in rodent and dog preclinical studies is in line with its twenty-fold differential activity in prostate cancer cells vs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

8 Samples

Download data: TXT