Similar studies for GEO DataSets (Select 684) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Links from GEO DataSets

Items: 11

Select item 6841.

T regulatory and T effector cells in prediabetic lesion

Comparison of T regulatory (CD4+CD25+CD69-) and T effector (CD4+CD25lo/-CD69+/-) cells isolated from the pancreatic lesion of 3-4 week old BDC2.5 transgenic NOD mice before type 1 diabetes onset.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell type sets

Platform:: GPL81
Series:: GSE1419
8 Samples

Download data: CEL

DataSet

Accession:: GDS684

ID:: 684

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000014192.

Pancreatic T regulatory vs. T effector cells

(Submitter supplied) Comparison of gene expression between T regulatory and T effector cells isolated from the pancreatic lesion of 3-4 wk old BDC2.5 tg NOD mice Keywords: cell type comparison

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS684
Platform:: GPL81
30 Samples

Download data: CEL

Series

Accession:: GSE1419

ID:: 200001419

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000346213.

Gene expression profiling of CD4+CD25+Foxp3+ regulatory T cells and CD4+CD25-Foxp3- T cells in the course of Plasmodium yoelii infection of BALB/c mice

(Submitter supplied) The objective of the present study was to characterize the phenotype of CD4+CD25+Foxp3+ regulatory T cells (Tregs) in the course of parasitic Plasmodium yoelii (P .yoelii) infection of BALB/c mice. Therefore we performed microarray expression analysis of CD4+CD25+Foxp3+ Tregs isolated by FACS from spleens of non-infected mice and from spleens of mice infected with P. yoelii 3 days and 5 days post infection. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
6 Samples

Download data: TXT

Series

Accession:: GSE34621

ID:: 200034621

Select item 2000391974.

Gene expression profiling of NK cells isolated from the pancreas of BDC TCR expressing NOD mice before or after Treg ablation by DTR. Also, NK cells cultured in vitro with activating cytokines IL12 and IL-18 with or without regulatory TGFb.

(Submitter supplied) Following Treg ablation in the BDC/NOD.Foxp3-DTR strain, NK cells produce IFNg and accumulate to higher percentage and number. We explored the signature pathways responsible for this phenomenon using microarray prolifing and comparison to other activation signatures.

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS4946 GDS4948
Platform:: GPL6246
41 Samples

Download data: CEL

Series

Accession:: GSE39197

ID:: 200039197

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 49485.

Transforming growth factor beta effect on cytokine-activated, NOD-derived, splenic natural killer cells

Analysis of NOD-derived, splenic natural killer (NK) cells cultured with or without cytokines interleukin (IL)-12 + IL-18 in the absence of TGF-β, or with both cytokines in the presence of TGF-β. Results provide insight into the impact of TGF-β on NK cells independent of general activation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 protocol, 2 time sets

Platform:: GPL6246
Series:: GSE39197
9 Samples

Download data: CEL

DataSet

Accession:: GDS4948

ID:: 4948

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 49466.

Regulatory T cell ablation effect on BDC2.5/NOD pancreatic or splenic natural killer cells: time course

Analysis of natural killer (NK) cells isolated from the pancreas or spleen of BDC2.5/NOD.Foxp3DTR animals up to 24 hours after diphtheria toxin (DT) injection to ablate regulatory T (Treg) cells. Results provide insight into molecular mechanisms underlying Treg/NK cross-talk in controlling diabetes.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation, 3 time, 2 tissue sets

Platform:: GPL6246
Series:: GSE39197
32 Samples

Download data: CEL

DataSet

Accession:: GDS4946

ID:: 4946

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000397247.

Gene expression analysis of iTregs and nTregs

(Submitter supplied) MBP TCR Tg mouse (1B3) generates only iTregs when crossed onto RAGKO background. Tregs from 1B3.RAG mouse were used for gene expression analsysis to determine genes selectively expressed in peripherally generated iTregs

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
42 Samples

Download data: TXT

Series

Accession:: GSE39724

ID:: 200039724

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000225278.

Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints

(Submitter supplied) Treatment with anti-CD3 is a promising therapeutic approach for autoimmune diabetes, but its mechanism of action remains unclear. Foxp3+ regulatory T (Treg) cells may be involved, but the evidence has been conflicting, and there is great uncertainty as to possible mechanistic connections. We investigated this issue in mice derived from the NOD model, which were engineered mice in which Treg populations were perturbed, or could be manipulated by acute ablation or transfer. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4018
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE22527

ID:: 200022527

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 40189.

Anti-CD3 monoclonal antibody effect on splenic Foxp3+ regulatory T cells

Analysis of sorted spleen T cells of BDC2.5 RAGo/o Foxp3 NOD mice after anti-CD3 treatment. Anti-CD3 treatment prevented diabetes development in BDC2.5.RAGo/o mice. Results provide insight into the mechanism of action of anti-CD3.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE22527
6 Samples

Download data: CEL

DataSet

Accession:: GDS4018

ID:: 4018

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20001316310.

Gene expression in the pancreatic lymph node of Deaf1 knock out mice vs. BALB/c controls

(Submitter supplied) A microarray study performed in the pancreatic lymph nodes of Deaf1 knock-out and BALB/c control mice to identify genes that are regulated by the transcriptional regulator Deaf1. These experiments constitute a portion of the study described below: Abstract: Type 1diabetes (T1D) can result from a breakdown in peripheral tolerance which is controlled by peripheral tissue antigen (PTA) expression in lymph nodes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
2 Samples

Download data

Series

Accession:: GSE13163

ID:: 200013163

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022823311.

10X single-cell RNA-seq profiling of T cells from the pancreas, pancreatic lymph nodes, and blood of NOD mice with spontaneous or anti-PD-1-induced Type 1 Diabetes

(Submitter supplied) Immune-related adverse events (irAEs) are a notable complication of PD-1 cancer immunotherapy. A better understanding of how these iatrogenic diseases compare to naturally arising autoimmune diseases is needed for treatment and monitoring of irAEs. We identified differences in anti-PD-1-induced Type 1 Diabetes (T1D) and spontaneous T1D in non-obese diabetic (NOD) mice by performing single-cell RNA-seq and TCR-seq on T cells from the pancreas, pancreas-draining lymph node (pLN), and blood of mice with PD-1-induced T1D or spontaneous T1D. more...