GEO DataSet Links for PMC (Select 3405999) - GEO DataSets

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Items: 3

Select item 2000386501.

Histone H2A mono-ubiquitination is a crucial step to mediate PRC1 dependent repression of developmental genes to maintain ES cell identity.

(Submitter supplied) Two distinct Polycomb complexes, PRC1 and PRC2, collaborate to maintain epigenetic repression of key developmental loci in embryonic stem cells (ESCs). PRC1 and PRC2 have histone modifying activities, catalyzing mono-ubiquitination of histone H2A (H2AK119u1) and trimethylation of H3 lysine 27 (H3K27me3) respectively. Compared to H3K27me3, localization and role of H2AK119ub1 is not fully understood in ESCs. more...

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by array

Platforms:: GPL14573 GPL14597 GPL1261
40 Samples

Download data: CEL, TXT

Series

Accession:: GSE38650

ID:: 200038650

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000385042.

ChIP-on-chip analysis of Ring1B, Ring1A, H2AK119u1 and H3K27me3 in mouse ES cells

(Submitter supplied) ChIP-on-chip analysis was carried out to determine targets of Ring1B, Ring1A, H2AK119u1 and H3K27me3 in mouse ES cells.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by array

Platforms:: GPL14597 GPL14573
28 Samples

Download data: TXT

Series

Accession:: GSE38504

ID:: 200038504

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000382243.

Expression data from Ring1A(-/-);Ring1B(fl/fl);R26::CreERT2 ES cells expressing either of mock, WT or mutant Ring1B construct before or after OHT treatment

(Submitter supplied) We used microarrays to investigate the restoration of repression of PRC1 target gene expression in Ring1A/B-dKO ES cells stably expressing either of mock, WT or mutant Ring1B construct.