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Items: 3

1.

The transcriptomic response of rat hepatic stellate cells to endotoxin: implications for hepatic inflammation and immune regulation

(Submitter supplied) Located in the perisinusoidal space of Disse, hepatic stellate cells (HSCs) communicate with all other liver cell types by physical association and / or by producing cytokines and chemokines. In liver disease and folllowing liver transplantation, elevated levels of endotoxin (bacterial lipopolysaccharide: LPS) stimulate HSCs to produce increased amounts of cytokines and chemokines. Transcriptomic analysis of cultured HSCs stimulated with LPS yields a survey of expression changes which potentially modulate the hepatic inflammatory and immune responses.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS5251 GDS5252
Platform:
GPL1355
11 Samples
Download data: CEL, TXT
Series
Accession:
GSE49980
ID:
200049980

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.
Full record GDS5252

Bacterial lipopolysaccharide endotoxin stimulation effect on hepatic stellate cells: time course (experiment 1)

Analysis of hepatic stellate cells (HSCs) cultured with LPS for 1, 3, 6, 12, 24 hr. During exposure to toxins such as LPS, the liver suffers inflammatory injury. Results provide insight into molecular mechanisms underlying hepatic inflammatory and immune responses.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 5 time sets
Platform:
GPL1355
Series:
GSE49980
11 Samples
Download data: CEL
DataSet
Accession:
GDS5252
ID:
5252

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

3.
Full record GDS5251

Bacterial lipopolysaccharide endotoxin stimulation effect on hepatic stellate cells: time course (experiment 2)

Analysis of hepatic stellate cells (HSCs) cultured with LPS for 1 and 24 hr. During exposure to toxins such as LPS, the liver suffers inflammatory injury. Results provide insight into molecular mechanisms underlying hepatic inflammatory and immune responses.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL1355
Series:
GSE49980
8 Samples
Download data: CEL
DataSet
Accession:
GDS5251
ID:
5251

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

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