GEO DataSet Links for PMC (Select 4047213) - GEO DataSets

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Items: 2

Select item 2000563321.

GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia

(Submitter supplied) Transient leukemia (TL) is evident in 5-10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1-mutations (GATA1s). Here we analyzed the effect of on gene expression upon ectopic expression of Gata1s or Gata1, while simultaneously knocking down endogenous GATA1, in wild-type CD34+-hematopoietic stem and progenitor cells during myeloid differentiation. Ectopic expression of Gata1s, but not Gata1, in wild-type CD34+-hematopoietic stem and progenitor cells induced hyperproliferation of eosinophil promyelocytes in vitro. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5368
Platform:: GPL6480
9 Samples

Download data: TXT

Series

Accession:: GSE56332

ID:: 200056332

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 53682.

N-terminal truncated GATA1-mutant effect on fetal CD34+ hematopoietic stem and progenitor cells: time course

Analysis of fetal CD34+ HSPCs expressing N-terminal truncated GATA1-mutant (GATA1s) during myeloid differentiation for 4 and 14 days. GATA1s mutations are associated with transient leukemia (TL)- in Down syndrome neonates. Results provide insight into the role of GATA1s in TL pathogenesis.