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Items: 4

1.

Human Cytomegalovirus in Glioblastoma Stemness--Results from Human, Mouse and HCMV DNA arrays

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens; Human betaherpesvirus 5
Type:
Expression profiling by array
Platforms:
GPL6246 GPL6244 GPL15366
14 Samples
Download data: CEL, GPR
Series
Accession:
GSE56752
ID:
200056752
2.

Cytomegalovirus promotes maintenance and growth of glioblastoma stem cells [HCMV gene expression]

(Submitter supplied) Primary human GBM stem like cells were infected with HCMV TR strain (MOI=1) and treated with IE siRNA (a combination of oligos targeting IE1 and IE2 HCMV genes) 72 hours following siRNA treatment, RNA was harvested using Qiagen and divided equally for profiling using Affymetrix arrays and HCMV arrays.
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Expression profiling by array
Platform:
GPL15366
2 Samples
Download data: GPR
Series
Accession:
GSE56750
ID:
200056750
3.

Cytomegalovirus promotes maintenance and growth of glioblastoma stem cells [Human gene expression]

(Submitter supplied) Primary human GBM stem like cells were infected with HCMV TR strain (MOI=1) and treated with IE siRNA (a combination of oligos targeting IE1 and IE2 HCMV genes) 72 hours following siRNA treatment, RNA was harvested using Qiagen and divided equally for profiling using Affymetrix arrays and HCMV arrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
4 Samples
Download data: CEL
Series
Accession:
GSE56715
ID:
200056715
4.

Cytomegalovirus promotes maintenance and growth of glioblastoma stem cells [Mouse gene expression]

(Submitter supplied) We introduced the HCMV IE1 gene into a mouse model of spontaneous glioma driven by p53KD and overexpression of Ras and PDGF and compared the transcriptomes of mouse gliomas +/- IE1. The following plasmids were utilized for glioma induction in equal parts: pT2/C-Luc/PGK-SB100, pT2/Cag-NrasV12, pT2/shP53/GFP4/mPDGF, and pT2/Cag-IE1 or pT2/C-Neo. Primary human glioma stem cells were maintained in neurosphere growth conditions, treated with IE1 and control siRNA for 48-72h prior to RNA harvesting. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE36337
ID:
200036337
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