GEO DataSet Links for PMC (Select 5825863) - GEO DataSets

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Items: 2

Select item 2001084651.

RNA sequencing of hPSC-derived cardiac progenitors and endocardium

(Submitter supplied) We utilized a dual reporting hPSC line that identified cells expressing NKX2.5 and endothelal cells to characterize discrete milestones during cardiac and vascular differentiaiton. Comparing populations that express either or both reporters to human umbilical vein endothelial cells, we document a unique molecular phenotype in hPSC-derived endocardium that points toward an important role for Wnt signaling during vascular specification of cardiac progenitors.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
9 Samples

Download data: TXT

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Accession:: GSE108465

ID:: 200108465

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000576622.

Reprogramming of Endothelium Into Hematopoietic Progenitors by Defined Factors and Vascular Induction

(Submitter supplied) Generation of abundant engraftable hematopoietic cells from autologous tissues promises new therapies for hematologic diseases. Differentiation of pluripotent stem cells into hematopoietic cells results in emergence of cells that have poor engraftment potential. To circumvent this hurdle, we have devised a vascular niche model to phenocopy the developmental microenvironment of hemogenic cells thereby enabling direct transcriptional reprogramming of human endothelial cells (ECs) into hematopoietic cells. more...