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Items: 8

1.

Impact of genome architecture upon the functional activation and repression of Hox regulatory landscapes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL17021 GPL21103
30 Samples
Download data: BEDGRAPH
Series
Accession:
GSE129427
ID:
200129427
2.

Impact of genome architecture upon the functional activation and repression of Hox regulatory landscapes [4C-seq]

(Submitter supplied) The spatial organization of the mammalian genome is complex and relies upon the formation of chromatin domains of various scales. At the level of gene regulation in cis, collections of enhancer sequences define large regulatory landscapes that usually match with the presence of topologically associating domains (TADs). These domains are largely determined by bound CTCF molecules and often contain ranges of enhancers displaying similar or related tissue specificity, suggesting that in some cases such domains may act as coherent regulatory units, with a global on or off state. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL17021
6 Samples
Download data: BEDGRAPH
Series
Accession:
GSE129426
ID:
200129426
3.

Impact of genome architecture upon the functional activation and repression of Hox regulatory landscapes [ChIP-seq]

(Submitter supplied) The spatial organization of the mammalian genome is complex and relies upon the formation of chromatin domains of various scales. At the level of gene regulation in cis, collections of enhancer sequences define large regulatory landscapes that usually match with the presence of topologically associating domains (TADs). These domains are largely determined by bound CTCF molecules and often contain ranges of enhancers displaying similar or related tissue specificity, suggesting that in some cases such domains may act as coherent regulatory units, with a global on or off state. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21103 GPL17021
16 Samples
Download data: BEDGRAPH
Series
Accession:
GSE129425
ID:
200129425
4.

Impact of genome architecture upon the functional activation and repression of Hox regulatory landscapes [RNA-seq]

(Submitter supplied) The spatial organization of the mammalian genome is complex and relies upon the formation of chromatin domains of various scales. At the level of gene regulation in cis, collections of enhancer sequences define large regulatory landscapes that usually match with the presence of topologically associating domains (TADs). These domains are largely determined by bound CTCF molecules and often contain ranges of enhancers displaying similar or related tissue specificity, suggesting that in some cases such domains may act as coherent regulatory units, with a global on or off state. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
8 Samples
Download data: BEDGRAPH
Series
Accession:
GSE129424
ID:
200129424
5.

A TAD boundary at the HoxD locus segregates opposing limb regulatory landscapes and their target genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Other; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL21103
91 Samples
Download data: BEDGRAPH, MATRIX, NARROWPEAK, TAR, TXT
Series
Accession:
GSE101717
ID:
200101717
6.

A TAD boundary at the HoxD locus segregates opposing limb regulatory landscapes and their target genes [Hi-C]

(Submitter supplied) The mammalian HoxD cluster is positioned at the boundary between two topologically associating domains (TADs), each of them matching a distinct, enhancer-rich regulatory landscape. During limb development, the telomeric TAD controls the early phase of Hoxd gene transcription in future forearm cells, whereas the centromeric TAD subsequently regulates transcription of more posterior Hoxd genes in presumptive digit cells. more...
Organism:
Mus musculus
Type:
Other; Third-party reanalysis
Platform:
GPL21103
6 Samples
Download data: MATRIX, TAR, TXT
Series
Accession:
GSE101715
ID:
200101715
7.

A TAD boundary at the HoxD locus segregates opposing limb regulatory landscapes and their target genes [ChIP-Seq]

(Submitter supplied) The mammalian HoxD cluster is positioned at the boundary between two topologically associating domains (TADs), each of them matching a distinct, enhancer-rich regulatory landscape. During limb development, the telomeric TAD controls the early phase of Hoxd gene transcription in future forearm cells, whereas the centromeric TAD subsequently regulates transcription of more posterior Hoxd genes in presumptive digit cells. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21103 GPL17021
13 Samples
Download data: BEDGRAPH, NARROWPEAK
Series
Accession:
GSE101714
ID:
200101714
8.

A TAD boundary at the HoxD locus segregates opposing limb regulatory landscapes and their target genes [4C-Seq]

(Submitter supplied) The mammalian HoxD cluster is positioned at the boundary between two topologically associating domains (TADs), each of them matching a distinct, enhancer-rich regulatory landscape. During limb development, the telomeric TAD controls the early phase of Hoxd gene transcription in future forearm cells, whereas the centromeric TAD subsequently regulates transcription of more posterior Hoxd genes in presumptive digit cells. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL17021
72 Samples
Download data: BEDGRAPH
Series
Accession:
GSE101713
ID:
200101713
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