GEO DataSet Links for PMC (Select 6706389) - GEO DataSets

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Items: 3

Select item 2001331311.

Transcriptomic profiling of vegfc(hy-/-);vegfd(-/-) mutant hearts reveals that vegfc/d signaling and lymphatics vasculature play a role in cardiac metabolism

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24995 GPL21741
22 Samples

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Series

Accession:: GSE133131

ID:: 200133131

PubMed Full text in PMC Similar studies

Select item 2001331302.

Transcriptomic profiling of vegfc(hy-/-);vegfd(-/-) mutant hearts reveals that vegfc/d signaling and lymphatics vasculature play a role in cardiac metabolism [fresh tissue]

(Submitter supplied) Recent studies have suggested that promoting lymphangiogenesis enhances cardiac repair following injury, but it is unknown whether lymphangiogenesis is required for cardiac regeneration. Here, we describe the anatomical distribution, regulation and function of the cardiac lymphatic network in a highly regenerative zebrafish model system using transgenic reporter lines and loss-of-function approaches.To understand the transcriptional profile of the model, we performed RNA-seq on cardiac ventricles from control and mutant (vegfc(hy-/-);vegfd(-/-)) ventricles. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24995
9 Samples

Download data: TXT

Series

Accession:: GSE133130

ID:: 200133130

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001331293.

Transcriptomic profiling of non-regenerative vegfc(hy-/-);vegfd(-/-) mutant hearts reveals a marked inflammatory response [fixed tissue]

(Submitter supplied) To determine whether lymphangiogenesis is required for cardiac regeneration, vegfc(hy-/-);vegfd(-/-) double mutants and control hearts were collected and analyzed at 180 days after cryoinjury, this corresponds to a time point when the regenerative response is normally completed in wild-type zebrafish. Surprisingly, the vast majority (~70%) of vegfc(hy-/-);vegfd(-/-) mutants, which completely lack cardiac lymphatics, were able to mount a complete regenerative response without any signs of fibrosis. more...