GEO DataSet Links for PMC (Select 9113400) - GEO DataSets

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Items: 2

Select item 2001812041.

Estrogen Drives Melanocortin Signaling to Increase Spontaneous Activity

(Submitter supplied) Transcriptional profilig of estradiol sensitive genes in the VMHvl of female mice

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
7 Samples

Download data: TXT

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Accession:: GSE181204

ID:: 200181204

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001414342.

Estrogen Drives Melanocortin Neurons To Reduce Sedentary Behavior

(Submitter supplied) Estrogen depletion in both rodents and humans leads to inactivity, unhealthy fat accumulation, and metabolic syndrome, underscoring the conserved metabolic benefits of estrogen signaling that inevitably decline with aging. Here, we uncover a hypothalamic node that integrates estrogen and melanocortin-4 receptor (MC4R) signaling to drive episodic bursts in activity prior to ovulation. Skirting the estrogen-dependent gating of this node by CRISPR activation of Mc4r reduces sedentary behavior long-term in both males and females. more...