GEO DataSet Links for SRA (Select 11915344) - GEO DataSets

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Items: 2

Select item 3047947881.

Tup1-V5_Input

Organism:: Saccharomyces cerevisiae

Source name:: log phase yeast cells

Platform:: GPL27812
Series:: GSE158180

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Accession:: GSM4794788

ID:: 304794788

SRA Run Selector

Select item 2001581802.

Ash1 and Tup1 Dependent Repression of the Saccharomyces cerevisiae HO promoter Requires Activator-Dependent Nucleosome Eviction

(Submitter supplied) Transcriptional regulation of the Saccharomyces cerevisiae HO gene is highly complex, requiring a balance of multiple activating and repressing factors to ensure that only a few transcripts are produced in mother cells within a narrow window of the cell cycle. Here, we show that the Ash1 repressor associates with two DNA sequences that are usually concealed within nucleosomes in the HO promoter and recruits the Tup1 corepressor and the Rpd3 histone deacetylase, both of which are required for full repression in daughters. more...