txid10090[orgn] AND "strain C57BL/6 B6 N"[All Fields] - GEO DataSets

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Items: 2

Select item 2000736311.

A XEN-like state bridges somatic cells to pluripotency during chemical reprogramming

(Submitter supplied) Pluripotent stem cells can be generated from somatic cells by using pure chemicals.However, the cell fate dynamics and molecular events that occur during the chemical reprogramming process remain unclear. In this study, we found that the chemical reprogramming process requires the early formation of extra-embryonic endoderm (XEN)-like cells and a late transition from XEN-like cells to CiPSCs, a new route that differs from the pathway of transcription factor-induced reprogramming. more...