GEO DataSets

(Submitter supplied) The differences between the ΔrspA1 mutant and the original strain A30 transcriptomes were analyzed at 30h in ferentaion cultures complemented with 75mM glutamate when the conditions preceding the differences observed in glucose consumption rate,pH and cell dry weight.

Organism:

Streptomyces albus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21996

4 Samples

Download data: TXT

(Submitter supplied) Streptomyces albus S12, TK and Tet30Chl25 are the parental strain , low-yield and high-yield of salinomycin mutant obtained by ARTP and ribosome engineering ,respectively. There are total 1602 differentially expressed genes (DEGs) show differences in expression between the mutant strain TK, Tet30Chl25 and the initial strain S12. KEGG pathway analysis of differentially expressed genes (DEGs) between the mutant strain TK, Tet30Chl25 and the initial strain S12 show that the relevant differential pathways affecting salinomycin production were mainly related to butanoate metabolism, starch and sucrose metabolism, glyoxylate metabolism. more...

Organism:

Streptomyces albus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21996

3 Samples

Download data: TXT

(Submitter supplied) On the example of the biosynthetically exhausted landomycin A cluster we demonstrate unbalancing of gene transcription as an efficient method for the generation of new compounds. Decoupled from the native regulators LanI and LanK, all landomycin A structural genes were set under the control of a single synthetic promoter and expressed in a heterologous host Streptomyces albus J1074. Previously being both temporarily and quantitatively regulated, these genes were transcribed as a single polycistronic mRNA leading to the production of four novel and two known compounds. more...

Organism:

Streptomyces albus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21996

2 Samples

Download data: CSV, TXT