GEO DataSets

(Submitter supplied) Pathogenic Candida fungi are a leading cause of opportunistic, hospital-associated bloodstream infections with high mortality rates, typically in immunocompromised patients. Several species, including C. albicans, the most prevalent cause of infection, belong to the monophyletic CUG clade of yeasts. Much is known about the interaction of C. albicans with innate immune cells, which are crucial for controlling infection. more...

Organism:

Candida albicans; Lodderomyces elongisporus; Mus musculus; Candida dubliniensis; Candida tropicalis; Candida parapsilosis; Clavispora lusitaniae

Type:

Expression profiling by high throughput sequencing

12 related Platforms

24 Samples

Download data: TXT

(Submitter supplied) The purpose of this experiment was to identify the genes bound by the regulator Ndt80 in C. albicans, C. dubliniensis and C. tropicalis during biofilm formation in different growth media. Ndt80 was tagged with a c-myc epitope in the three species and the immunoprecipitation of the tagged strain was compared to that of an untagged control strain in two different media for each species.

Organism:

Candida tropicalis; Candida albicans; Candida dubliniensis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL29382 GPL19036 GPL29383

24 Samples

Download data: TXT

(Submitter supplied) The purpose of this experiment was to identify the genes bound by the biofilm master regulators (Bcr1, Brg1, Efg1, Ndt80, Rob1 and Tec2) in Candida albicans, C. dubliniensis, C. tropicalis and C. parapsilosis during biofilm formation. The regulators were tagged with a c-myc epitope and the immunoprecipitation of the tagged strain was compared to that of an untagged control strain.

Organism:

Candida albicans; Candida parapsilosis; Candida tropicalis; Candida dubliniensis

Type:

Genome binding/occupancy profiling by high throughput sequencing

6 related Platforms

61 Samples

Download data: TXT

(Submitter supplied) The goal was to identify genes that change their expression in biofilm vs. planktonic growth. Cultures for the extraction of total RNA under biofilm growth conditions were performed on biofilms grown on the bottom of 6-well polystyrene plates for 48 hours at 37°C and 200 rpm as previously described (Nobile et al. 2012). The media used was Spider 1% glucose and RPMI 1% glucose. Planktonic cultures for total RNA were grown in the same media by inoculating with cells from an overnight 30°C YPD culture to an OD600 of 0.05. more...

Organism:

Candida tropicalis

Type:

Expression profiling by array

Platform:

GPL29364

8 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida tropicalis; Candida albicans; Candida parapsilosis; Candida albicans x Candida dubliniensis; Candida dubliniensis

Type:

Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

11 related Platforms

127 Samples

Download data: GPR, TXT

(Submitter supplied) Candidiasis affects a wide variety of immunocompromised individuals, including HIV/AIDS patients and cancer patients on chemotherapy. Candida albicans, a major human fungal pathogen, accounts for about 50% of all cases, while the remainder are caused by the less pathogenic non-albicans Candida species (NACS). These species are believed to be less pathogenic, in part, because they do not filament as readily or robustly as C. more...

Organism:

Candida parapsilosis; Candida tropicalis

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21876 GPL18663

16 Samples

Download data: TXT

(Submitter supplied) Homo sapiens fresh whole blood was infected with Candida tropicalis. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Measurement of Candida tropicalis gene expression.

Organism:

Homo sapiens; Candida tropicalis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24977

18 Samples

Download data: CSV

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida tropicalis; Candida albicans; Candida parapsilosis; Nakaseomyces glabratus; Homo sapiens

Type:

Expression profiling by high throughput sequencing

5 related Platforms

75 Samples

Download data

(Submitter supplied) Phenotypic switching is a strategy by which microbial organisms adapt to environmental changes. The human fungal pathogens, Candida albicans and Candida tropicalis, are closely related species and capable of undergoing morphological transitions. C. albicans primarily exists in human or warm-blooded animals as a commensal, whereas C. tropicalis not only exists as a commensal but also is widely distributed in the environment. more...

Organism:

Candida tropicalis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21876

6 Samples

Download data: TXT

(Submitter supplied) Phenotypic plasticity, the ability to switch between different morphological types, plays critical roles in environmental adaptation, leading to infections, and allowing for sexual reproduction in pathogenic Candida species. Candida tropicalis, which is both an emerging human fungal pathogen and an environmental fungus, can switch between two heritable cell types termed white and opaque. In this study, we report the discovery of a novel phenotype in C. more...

Organism:

Candida tropicalis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21876

3 Samples

Download data: TXT

(Submitter supplied) The yeast-filament transition is essential for the virulence of a variety of fungi that are pathogenic to humans. N-acetylglucosamine (GlcNAc), a ubiquitous molecule in both the environment and host, is one of the most potent inducers of filamentation in Candida albicans and thermally dimorphic fungi such as Histoplasma capsulatum and Blastomyces dermatitidis. However, GlcNAc suppresses rather than promotes filamentation in Candida tropicalis, a fungal species that is closely related to C. more...

Organism:

Candida tropicalis MYA-3404

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20946

2 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of a-type wor1 deleted cells and mixed a-type and alpha-type opaque cells under in vitro biofilm-forming conditions. Specifically, they were grown for two days at room temperature in a 12-well poly-styrene plate containing 1 ml of Lee's + Glucose liquid media. Samples were hybridized against a universal mixed reference sample of a-type cells in white and opaque states grown in Spider liquid media.

Organism:

Candida tropicalis

Type:

Expression profiling by array

Platform:

GPL15925

4 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of C. tropicalis a cells (CAY1503) in opaque state and overexpressing Wor1 in biofilms hybridized against a universal mixed reference sample of a cells in white and opaque states grown in Spider liquid.

Organism:

Candida tropicalis

Type:

Expression profiling by array

Platform:

GPL15925

4 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of C. tropicalis a/alpha cells (CAY1511) in white state, opaque state, overexpressing Wor1, or wor1 mutants hybridized against a universal mixed reference sample from all 4 states.

Organism:

Candida tropicalis

Type:

Expression profiling by array

Platform:

GPL15925

16 Samples

Download data: GPR

(Submitter supplied) Sexual reproduction can promote genetic diversity in eukaryotes, and yet many pathogenic fungi have been labeled as obligate asexual species. It is becoming increasingly clear, however, that cryptic sexual programs may exist in some species, and that efficient mating requires the necessary developmental switch to be triggered. In this study we investigate Candida tropicalis, an important human fungal pathogen that has been reported to be asexual. more...

Organism:

Candida tropicalis

Type:

Expression profiling by array

Platform:

GPL15925

8 Samples

Download data: GPR

(Submitter supplied) Microarray for expression profiling of Candida tropicalis Arrays of this design have barcodes that begin with 16042593 or 2542593. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. The ID column represents the Agilent Feature Extraction feature number. more...

Organism:

Candida tropicalis

2 Series

8 Samples

Download data: TXT