U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 210

1.

Systems Toxicology Identifies Mechanistic Impacts of 2-amino-4,6-dinitrotoluene (2-ADNT) Exposure in Northern Bobwhite

(Submitter supplied) A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to pursue a holistic understanding of the effects of the explosives degradation product 2-amino-4,6-dinitrotoluene (2A-DNT) dosing on the health of the wildlife bird model, Northern bobwhite (Colinus virginianus). A subchronic 60d toxicology bioassay was leveraged where both sexes were dosed via daily gavage with 0, 3, 14, or 30 mg/kg-d 2-ADNT. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL9548
64 Samples
Download data: TXT
Series
Accession:
GSE59910
ID:
200059910
2.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 7 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
24 Samples
Download data: TXT
Series
Accession:
GSE33935
ID:
200033935
3.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 6 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
8 Samples
Download data: TXT
Series
Accession:
GSE33934
ID:
200033934
4.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 5 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
8 Samples
Download data: TXT
Series
Accession:
GSE33932
ID:
200033932
5.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 4 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
24 Samples
Download data: TXT
Series
Accession:
GSE33928
ID:
200033928
6.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 3 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
24 Samples
Download data: TXT
Series
Accession:
GSE33919
ID:
200033919
7.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 2 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
11 Samples
Download data: TXT
Series
Accession:
GSE33893
ID:
200033893
8.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 1 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
11 Samples
Download data: TXT
Series
Accession:
GSE33888
ID:
200033888
9.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
110 Samples
Download data: TXT
Series
Accession:
GSE27653
ID:
200027653
10.

Bobwhite Quail 2,6-DNT

(Submitter supplied) Investigating the effects of a subchronic (60d) exposure to the munitions constituent (MC) 2,6-DNT on Northern bobwhite.
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL9548
24 Samples
Download data: TXT
Series
Accession:
GSE18940
ID:
200018940
11.

US Army Northern bobwhite (Colinus virginianus) custom brain tissue cDNA microarray

(Submitter supplied) Northern bobwhite Protocol: Microarrays were constructed by spotting the Northern bobwhite cDNA library, ArrayControl™ Spot cDNAs (Ambion), and printing buffer blanks onto Ultra GAPS-coated microarray slides (Corning Inc., Corning, NY). Spotted cDNAs were immobilized on the chip surface by applying 300 mJ of UV radiation in a Stratagene™ UV Stratalinker 2400 (Agilent Technologies, Waldbronn, Germany). more...
Organism:
Colinus virginianus
8 Series
110 Samples
Download data
Platform
Accession:
GPL14917
ID:
100014917
12.

Agilent-018586 Bobwhite Quail 15K Microarray

(Submitter supplied) see manufacturer's web site at http://www.agilent.com/
Organism:
Colinus virginianus
2 Series
88 Samples
Download data
Platform
Accession:
GPL9548
ID:
100009548
13.

Male, Liver, 30 mg/kg-d, Replicate 4

Organism:
Colinus virginianus
Source name:
Liver tissue from male
Platform:
GPL9548
Series:
GSE59910
Download data: TXT
Sample
Accession:
GSM1453520
ID:
301453520
14.

Male, Liver, 30 mg/kg-d, Replicate 3

Organism:
Colinus virginianus
Source name:
Liver tissue from male
Platform:
GPL9548
Series:
GSE59910
Download data: TXT
Sample
Accession:
GSM1453519
ID:
301453519
15.

Male, Liver, 30 mg/kg-d, Replicate 2

Organism:
Colinus virginianus
Source name:
Liver tissue from male
Platform:
GPL9548
Series:
GSE59910
Download data: TXT
Sample
Accession:
GSM1453518
ID:
301453518
16.

Male, Liver, 30 mg/kg-d, Replicate 1

Organism:
Colinus virginianus
Source name:
Liver tissue from male
Platform:
GPL9548
Series:
GSE59910
Download data: TXT
Sample
Accession:
GSM1453517
ID:
301453517
17.

Male, Liver, 14 mg/kg-d, Replicate 4

Organism:
Colinus virginianus
Source name:
Liver tissue from male
Platform:
GPL9548
Series:
GSE59910
Download data: TXT
Sample
Accession:
GSM1453516
ID:
301453516
18.

Male, Liver, 14 mg/kg-d, Replicate 3

Organism:
Colinus virginianus
Source name:
Liver tissue from male
Platform:
GPL9548
Series:
GSE59910
Download data: TXT
Sample
Accession:
GSM1453515
ID:
301453515
19.

Male, Liver, 14 mg/kg-d, Replicate 2

Organism:
Colinus virginianus
Source name:
Liver tissue from male
Platform:
GPL9548
Series:
GSE59910
Download data: TXT
Sample
Accession:
GSM1453514
ID:
301453514
20.

Male, Liver, 14 mg/kg-d, Replicate 1

Organism:
Colinus virginianus
Source name:
Liver tissue from male
Platform:
GPL9548
Series:
GSE59910
Download data: TXT
Sample
Accession:
GSM1453513
ID:
301453513
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=txid9014[Organism]|query=1|qty=2|blobid=MCID_669a633a56cb0a044e95fbd8|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center