GEO DataSets

(Submitter supplied) Bats harbor highly virulent viruses that can infect other mammals, including humans, posing questions about their immune tolerance mechanisms. Bat cells employ multiple strategies to limit virus replication and virus-induced immunopathology, but the coexistence of bats and fatal viruses remains poorly understood. Here, we investigated the antiviral RNA interference (RNAi) pathway in bat cells and discovered that they have an enhanced antiviral RNAi response, producing canonical viral small interfering RNAs (vsiRNAs) upon Sindbis virus (SINV) infection that were missing in human cells. more...

Organism:

Tadarida brasiliensis; Homo sapiens; Pteropus alecto

Type:

Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL11154 GPL15898 GPL34381

12 Samples

Download data: XLS

(Submitter supplied) The transcriptome of PaLung cells and WI-38 cells were compared to identify differences in central metabolism

Organism:

Homo sapiens; Pteropus alecto

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL26396 GPL21290

6 Samples

Download data: TXT

(Submitter supplied) To examine innate immune signalling, IFN baseline and IRF-regulation, we profile Pteropus alecto bat kidney epithelial cells (PakiT03) with Deep NGS coverage. Clonal cell lines were also isolated with CrispR KO for IRF1, IRF3, IRF7, IFNAR2 or IFNAR2/IRF7 double KO.

Organism:

Pteropus alecto

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26396

52 Samples

Download data: TXT

(Submitter supplied) To examine the fundamental immunity in bats, particularly the status of their innate immune system in the basal healthy state, we profile Pteropus alecto bat tissue with Deep NGS coverage. This is coupled to a paired experiment where bats were stimulated in vivo with various PRR ligands to activate immune pathways.

Organism:

Pteropus alecto

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26396

13 Samples

Download data: TXT

(Submitter supplied) Bats are reservoirs of a number of highly pathogenic human viruses, yet they remain relatively asymptomatic during infection. Whether this viral resistance is due to a unique immune system is unknown. An evolutionarily conserved feature of vertebrate antiviral immunity is the interferon (IFN) response, which triggers cellular defenses through interferon-stimulated gene (ISG) expression. While bats encode an intact IFN system, global ISG expression patterns in bat cells are not well characterized. more...

Organism:

Pteropus alecto

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23872

15 Samples

Download data: TXT

(Submitter supplied) Deep sequencing of mRNA from Pteropus alecto and Myotis davidii

Organism:

Myotis davidii; Pteropus alecto

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16126 GPL15898

2 Samples

Download data: FA, WIG