GEO DataSets

(Submitter supplied) HIV associated immune activation (IA) is associated with increased morbidity in people living with HIV (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the HIV reservoir. The underlying mechanisms of IA have not been definitively elucidated, however, persistent production of Type I IFNs and expression of ISGs is considered to be one of the primary factors. Plasmacytoid DCs (pDCs) are a major producer of Type I IFN during viral infections, and are highly immunomodulatory in acute HIV and SIV infection, however their role in chronic HIV/SIV infection has not been firmly established. more...

Organism:

Cercocebus atys; Macaca mulatta

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL23804 GPL23805

56 Samples

Download data: TXT

(Submitter supplied) To characterize more broadly the effect of attenuated TLR4 signaling responses in sooty mangabeys, we performed a comparative RNA-seq profiling of LPS-treated primary monocytes from rhesus macaques and sooty mangabeys. Production of TNF- and IL6 mRNA was significantly lower in sooty mangabeys. Moreover, we observed that induction of NF-κB -regulated inflammatory genes was broadly and significantly reduced in sooty mangabeys, for TNF-a and IL-6 signaling pathways, compared to rhesus macaques. more...

Organism:

Cercocebus atys; Macaca mulatta

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL23804 GPL23805

24 Samples

Download data: TXT

(Submitter supplied) Infections with mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium bovis (M. bovis) BCG, are a leading cause of morbidity and mortality for HIV-infected persons. In contrast to HIV, SIV infection of sooty mangabeys is nonpathogenic, characterized by a lack of clinical disease including an absence of opportunistic infections. The goal of this study was to identify innate immune responses to M. more...

Organism:

Macaca mulatta; Cercocebus atys; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL21947

44 Samples

Download data: RCC

(Submitter supplied) Transcriptional profiling of Double Negative (CD4-/CD8-) T-cells isolated from SIV infected Sooty Mangebys. DN T-cells were stimulated through the T-Cell receptor using anti CD3/CD28 antibodies for 4 hours and compared to unstimulated DN T-cells.

Organism:

Cercocebus atys; Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL16026

16 Samples

Download data: TXT

(Submitter supplied) In contrast to pathogenic HIV and SIV infection of humans and macaques, SIV infection of sooty mangabeys (SMs) is typically non-pathogenic despite high virus replication. A key feature of primary SIV infection of SMs is a strong type I interferon (IFN-I) response, characterized by massive up-regulation of interferon-stimulated genes (ISG), followed by rapid resolution during the acute-to-chronic phase transition and establishment of an immune quiescent state that persists throughout the chronic infection. more...

Organism:

Cercocebus atys; Macaca mulatta

Type:

Expression profiling by array

Dataset:

GDS4237

Platform:

GPL3535

47 Samples

Download data: CEL

Temporal analysis of whole blood from 8 naturally SIV-infected SMs treated with recombinant RM IFNalpha2-IgFc (rmIFNα2) for 16 weeks. SIV infection of SMs is typically non-pathogenic. Results provide insight into effects of experimentally-augmented IFN-I signaling in chronically SIV-infected SMs.

Organism:

Cercocebus atys; Macaca mulatta

Type:

Expression profiling by array, transformed count, 2 agent, 8 individual, 6 time sets

Platform:

GPL3535

Series:

GSE35460

47 Samples

Download data: CEL

(Submitter supplied) In SIV/HIV infection, the gastrointestinal tissue dominates as an important site due to the impact of massive mucosal CD4 depletion and immune activation-induced tissue pathology. Unlike AIDS-susceptible rhesus macaques, natural hosts do not progress to AIDS and resolve immune activation earlier. Here, we examine the role of dendritic cells in mediating immune activation and disease progression. We demonstrate that plasmacytoid dendritic cells (pDC) in the blood upregulate β7-integrin and are rapidly recruited to the colorectum following a pathogenic SIV infection in rhesus macaques. more...

Organism:

Cercocebus atys; Macaca mulatta

Type:

Expression profiling by array

Dataset:

GDS4230

Platform:

GPL3535

16 Samples

Download data: CEL

Analysis of colorectal biopsies from SIV-infected Rhesus macaques (RM) and Sooty mangabeys (SM). Unlike AIDS-susceptible RMs, natural hosts such as SMs do not progress to AIDS. Results provide insight into molecular basis of immune activation following pathogenic immunodeficiency virus infections.

Organism:

Cercocebus atys; Macaca mulatta

Type:

Expression profiling by array, transformed count, 3 infection, 2 species, 3 time sets

Platform:

GPL3535

Series:

GSE29980

16 Samples

Download data: CEL

(Submitter supplied) Transcriptional Profiling Reveals Distinguishing Features of Immune Activation in the Lymphatic Tissues of Sooty Mangabeys and Rhesus Macaques in Early SIV Infection Immune activation in the chronic stages of HIV-1 and SIV infection of rhesus macaques is thought to play a critical role in CD4+ T cell depletion and progression to AIDS. Conversely, the lack of immune activation in the chronic stages of SIV infection of sooty mangabeys is thought to protect this species from a pathogenic outcome. more...

Organism:

Cercocebus atys; Macaca mulatta

Type:

Expression profiling by array

Dataset:

GDS4223

Platform:

GPL3535

28 Samples

Download data: CEL

(Submitter supplied) Natural SIV infection of sooty mangabeys (SMs) does not progress to disease despite chronic virus replication. In contrast to pathogenic SIV infection of rhesus macaques (RMs), chronic SIV infection of SMs is characterized by low immune activation. To elucidate the mechanisms underlying this phenotype, we longitudinally assessed host gene expression in SIV-infected SMs and RMs. We found that acute SIV infection of SMs is consistently associated with a robust innate immune response, including widespread up-regulation of interferon-stimulated genes (ISGs). more...

Organism:

Cercocebus atys; Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

94 Samples

Download data: CEL

Temporal analysis of lymph nodes of SIVsmm infected Sooty mangabeys (SM) and SIVmac239 infected Rhesus macaques (RM). SIVsmm is non-pathogenic to host SM but origin of pathogens (HIV-2/SIVmac) to humans and RM. Results provide insight into the molecular basis of the differences in host responses.

Organism:

Cercocebus atys; Macaca mulatta

Type:

Expression profiling by array, count, 3 disease state, 3 infection, 2 species, 3 time sets

Platform:

GPL3535

Series:

GSE17626

28 Samples

Download data: CEL