U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ANKRD24 ankyrin repeat domain 24 [ Homo sapiens (human) ]

Gene ID: 170961, updated on 17-Jun-2024

Summary

Go to the top of the page Help
Official Symbol
ANKRD24provided by HGNC
Official Full Name
ankyrin repeat domain 24provided by HGNC
Primary source
HGNC:HGNC:29424
See related
Ensembl:ENSG00000089847 MIM:620234; AllianceGenome:HGNC:29424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 3.5), testis (RPKM 2.5) and 16 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ANKRD24 in Genome Data Viewer
Location:
19p13.3
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4182689..4224814)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4165992..4208117)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4182686..4224811)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 3 like 3 Neighboring gene Sharpr-MPRA regulatory region 11650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13760 Neighboring gene sirtuin 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4199326-4199972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4199973-4200619 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:4204935-4205148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4216177-4216676 Neighboring gene MPRA-validated peak3273 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:4230793-4231294 Neighboring gene MPRA-validated peak3276 silencer Neighboring gene Epstein-Barr virus induced 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13764 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:4246137-4246908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13766 Neighboring gene YJU2 splicing factor homolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points. Krey JF, et al. J Cell Biol, 2022 Apr 4. PMID 35175278, Free PMC Article
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. Nagase T, et al. DNA Res, 2001 Dec 31. PMID 11853319
  3. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article
  4. Protein interactome reveals converging molecular pathways among autism disorders. Sakai Y, et al. Sci Transl Med, 2011 Jun 8. PMID 21653829, Free PMC Article
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points.
    Title: ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Clone Names

  • KIAA1981

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in auditory receptor cell stereocilium organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sensory perception of sound ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in stereocilium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ankyrin repeat domain-containing protein 24

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393552.1 → NP_001380481.1  ankyrin repeat domain-containing protein 24 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC005578, AC006930
    Conserved Domains (5) summary
    COG0666
    Location:110 → 246
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG1196
    Location:331 → 1113
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:765 → 1109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00045
    Location:147 → 187
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:223 → 275
    Ank_4; Ankyrin repeats (many copies)

  2. NM_001393553.1 → NP_001380482.1  ankyrin repeat domain-containing protein 24 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC005578, AC006930
    Consensus CDS
    CCDS45925.1
    UniProtKB/Swiss-Prot
    O75268, O95781, Q8TF21
    Conserved Domains (3) summary
    TIGR02168
    Location:324 → 1100
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00045
    Location:115 → 145
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:119 → 211
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_001393555.1 → NP_001380484.1  ankyrin repeat domain-containing protein 24 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC005578, AC006930
    Conserved Domains (5) summary
    COG0666
    Location:81 → 208
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG1196
    Location:293 → 1075
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:727 → 1071
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00045
    Location:86 → 116
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:185 → 237
    Ank_4; Ankyrin repeats (many copies)

  4. NM_001393556.1 → NP_001380485.1  ankyrin repeat domain-containing protein 24 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC005578, AC006930
    Related
    ENSP00000262970.4, ENST00000262970.9
    Conserved Domains (5) summary
    COG0666
    Location:82 → 209
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG1196
    Location:294 → 1076
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:728 → 1072
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00045
    Location:87 → 117
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:186 → 238
    Ank_4; Ankyrin repeats (many copies)

  5. NM_001393557.1 → NP_001380486.1  ankyrin repeat domain-containing protein 24 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC005578, AC006930
    Conserved Domains (5) summary
    COG0666
    Location:94 → 221
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG1196
    Location:306 → 1088
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:740 → 1084
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00045
    Location:99 → 129
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:198 → 250
    Ank_4; Ankyrin repeats (many copies)

  6. NM_001393985.1 → NP_001380914.1  ankyrin repeat domain-containing protein 24 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC005578, AC006930
    Consensus CDS
    CCDS45925.1
    UniProtKB/Swiss-Prot
    O75268, O95781, Q8TF21
    Related
    ENSP00000321731.4, ENST00000318934.9
    Conserved Domains (3) summary
    TIGR02168
    Location:324 → 1100
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00045
    Location:115 → 145
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:119 → 211
    Ank_2; Ankyrin repeats (3 copies)

  7. NM_133475.1 → NP_597732.1  ankyrin repeat domain-containing protein 24 isoform b

    See identical proteins and their annotated locations for NP_597732.1

    Status: VALIDATED

    Source sequence(s)
    AB075861, AC005578, BI914435, BX117359, BX359277, CN286920
    Consensus CDS
    CCDS45925.1
    UniProtKB/Swiss-Prot
    O75268, O95781, Q8TF21
    Related
    ENSP00000471252.1, ENST00000600132.5
    Conserved Domains (3) summary
    TIGR02168
    Location:324 → 1100
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00045
    Location:115 → 145
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:119 → 211
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4182689..4224814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527761.2 → XP_011526063.1  ankyrin repeat domain-containing protein 24 isoform X4

    See identical proteins and their annotated locations for XP_011526063.1

    Conserved Domains (7) summary
    cd00204
    Location:115 → 243
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04094
    Location:567 → 981
    DUF390; Protein of unknown function (DUF390)
    pfam12796
    Location:119 → 253
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:147 → 187
    ANK; ANK repeat [structural motif]
    cl02219
    Location:1093 → 1170
    Bap31; B-cell receptor-associated protein 31-like
    cl23720
    Location:1047 → 1135
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23750
    Location:864 → 969
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  2. XM_011527756.3 → XP_011526058.2  ankyrin repeat domain-containing protein 24 isoform X2

  3. XM_011527758.3 → XP_011526060.2  ankyrin repeat domain-containing protein 24 isoform X3

  4. XM_017026438.2 → XP_016881927.1  ankyrin repeat domain-containing protein 24 isoform X4

    Conserved Domains (7) summary
    cd00204
    Location:115 → 243
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04094
    Location:567 → 981
    DUF390; Protein of unknown function (DUF390)
    pfam12796
    Location:119 → 253
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:147 → 187
    ANK; ANK repeat [structural motif]
    cl02219
    Location:1093 → 1170
    Bap31; B-cell receptor-associated protein 31-like
    cl23720
    Location:1047 → 1135
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23750
    Location:864 → 969
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  5. XM_024451405.2 → XP_024307173.2  ankyrin repeat domain-containing protein 24 isoform X1

  6. XM_011527764.4 → XP_011526066.2  ankyrin repeat domain-containing protein 24 isoform X5

  7. XM_011527765.3 → XP_011526067.1  ankyrin repeat domain-containing protein 24 isoform X6

    Conserved Domains (7) summary
    cd00204
    Location:87 → 215
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04094
    Location:539 → 953
    DUF390; Protein of unknown function (DUF390)
    pfam07989
    Location:1098 → 1150
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam12796
    Location:91 → 225
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:119 → 159
    ANK; ANK repeat [structural motif]
    cl23720
    Location:1019 → 1107
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23750
    Location:836 → 941
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  8. XM_047438378.1 → XP_047294334.1  ankyrin repeat domain-containing protein 24 isoform X7

  9. XM_017026441.2 → XP_016881930.1  ankyrin repeat domain-containing protein 24 isoform X8

  10. XM_011527768.3 → XP_011526070.1  ankyrin repeat domain-containing protein 24 isoform X9

    Conserved Domains (1) summary
    cl02219
    Location:674 → 751
    Bap31; B-cell receptor-associated protein 31-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4165992..4208117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320128.1 → XP_054176103.1  ankyrin repeat domain-containing protein 24 isoform X4

  2. XM_054320126.1 → XP_054176101.1  ankyrin repeat domain-containing protein 24 isoform X2

  3. XM_054320127.1 → XP_054176102.1  ankyrin repeat domain-containing protein 24 isoform X3

  4. XM_054320129.1 → XP_054176104.1  ankyrin repeat domain-containing protein 24 isoform X4

  5. XM_054320125.1 → XP_054176100.1  ankyrin repeat domain-containing protein 24 isoform X1

  6. XM_054320130.1 → XP_054176105.1  ankyrin repeat domain-containing protein 24 isoform X5

  7. XM_054320131.1 → XP_054176106.1  ankyrin repeat domain-containing protein 24 isoform X6

  8. XM_054320132.1 → XP_054176107.1  ankyrin repeat domain-containing protein 24 isoform X7

  9. XM_054320133.1 → XP_054176108.1  ankyrin repeat domain-containing protein 24 isoform X8

  10. XM_054320134.1 → XP_054176109.1  ankyrin repeat domain-containing protein 24 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TF21.2 GenPept UniProtKB/Swiss-Prot:Q8TF21

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools