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clip2 CAP-GLY domain containing linker protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 556406, updated on 17-Aug-2024

Summary

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Official Symbol
clip2provided by ZNC
Official Full Name
CAP-GLY domain containing linker protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-100727-3
See related
Ensembl:ENSDARG00000059596 AllianceGenome:ZFIN:ZDB-GENE-100727-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be active in cytoplasm; microtubule plus-end; and nucleus. Orthologous to human CLIP2 (CAP-Gly domain containing linker protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (59397144..59480161)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (58727724..58810457)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uroplakin 3b Neighboring gene RAS p21 protein activator 4 Neighboring gene GTF2I repeat domain containing 1 Neighboring gene deltex 2, E3 ubiquitin ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration. Weng JH, et al. Nat Chem Biol, 2013 Oct. PMID 23955365
  2. Neural differentiation modulates the vertebrate brain specific splicing program. Madgwick A, et al. PLoS One, 2015. PMID 25993117, Free PMC Article
  3. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CAP-Gly domain-containing linker protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    59397144..59480161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476654.1 → XP_021332329.1  CAP-Gly domain-containing linker protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q4W2, F8W339
    Conserved Domains (2) summary
    pfam01302
    Location:205 → 269
    CAP_GLY; CAP-Gly domain
    cl25732
    Location:341 → 994
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_021476655.1 → XP_021332330.1  CAP-Gly domain-containing linker protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B003
    Conserved Domains (2) summary
    pfam01302
    Location:205 → 269
    CAP_GLY; CAP-Gly domain
    cl25732
    Location:345 → 886
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_021476656.1 → XP_021332331.1  CAP-Gly domain-containing linker protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BJA6, F1QIN6
    Conserved Domains (2) summary
    pfam01302
    Location:205 → 269
    CAP_GLY; CAP-Gly domain
    cl25732
    Location:345 → 869
    SMC_N; RecF/RecN/SMC N terminal domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394620.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    24109..107126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_679197.8 → XP_684289.2  CAP-Gly domain-containing linker protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q4W2, F8W339
    Conserved Domains (2) summary
    pfam01302
    Location:205 → 269
    CAP_GLY; CAP-Gly domain
    cl25732
    Location:341 → 994
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_009301892.3 → XP_009300167.1  CAP-Gly domain-containing linker protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B003
    Conserved Domains (2) summary
    pfam01302
    Location:205 → 269
    CAP_GLY; CAP-Gly domain
    cl25732
    Location:345 → 886
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_005172017.4 → XP_005172074.1  CAP-Gly domain-containing linker protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BJA6, F1QIN6
    Conserved Domains (2) summary
    pfam01302
    Location:205 → 269
    CAP_GLY; CAP-Gly domain
    cl25732
    Location:345 → 869
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein
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