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    TP53 tumor protein p53 [ Homo sapiens (human) ]

    Gene ID: 7157, updated on 29-Oct-2024

    Summary

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    Official Symbol
    TP53provided by HGNC
    Official Full Name
    tumor protein p53provided by HGNC
    Primary source
    HGNC:HGNC:11998
    See related
    Ensembl:ENSG00000141510 MIM:191170; AllianceGenome:HGNC:11998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P53; BCC7; LFS1; BMFS5; TRP53
    Summary
    This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
    Expression
    Ubiquitous expression in spleen (RPKM 13.2), lymph node (RPKM 13.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Try the new Transcript table

    Genomic context

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    See TP53 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7668421..7687490, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7572544..7591594, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7571739..7590808, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11640 Neighboring gene sex hormone binding globulin Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7551198-7551407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7552896-7553396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7553397-7553897 Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7554172-7554814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7558514-7559332 Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7571230-7572027 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7580287-7580898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7580899-7581510 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7581511-7582121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11641 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:7589699-7590898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11643 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr17:7606219-7607112 and GRCh37_chr17:7607113-7608004 Neighboring gene WD repeat containing antisense to TP53 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7608898-7609789 Neighboring gene ephrin B3 Neighboring gene dynein axonemal heavy chain 2 Neighboring gene ribosomal protein L29 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Impact of p53 function on the sulfotransferase-mediated bioactivation of the alkylated polycyclic aromatic hydrocarbon 1-hydroxymethylpyrene in vitro. Wohak LE, et al. Environ Mol Mutagen, 2019 Oct. PMID 31102418
    2. Inhibition of p53 alleviates prostate cell apoptosis in Escherichia coli‑induced bacterial prostatitis. Wang H, et al. Mol Med Rep, 2019 Aug. PMID 31173258
    3. Methylation in the TP53 promoter is associated with ischemic stroke. Wei Y, et al. Mol Med Rep, 2019 Aug. PMID 31173230
    4. A correlation of immunohistochemical expression of TP53 and severity of inflammation with varying grades of oral squamous cell carcinoma. Pandya JA, et al. J Cancer Res Ther, 2019 Jul-Sep. PMID 31169221
    5. Correlations between P53 Mutation Status and Texture Features of CT Images for Hepatocellular Carcinoma. Wu H, et al. Methods Inf Med, 2019 Jun. PMID 31163452

    See all (1000) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Entrainment and multi-stability of the p53 oscillator in human cells.
      Title: Entrainment and multi-stability of the p53 oscillator in human cells.
    2. Case series of Li-Fraumeni syndrome: carcinogenic mechanisms in breast cancer with TP53 pathogenic variant carriers.
      Title: Case series of Li-Fraumeni syndrome: carcinogenic mechanisms in breast cancer with TP53 pathogenic variant carriers.
    3. Influence of TP53 gene mutations and their allelic status in myelodysplastic syndromes with isolated 5q deletion.
      Title: Influence of TP53 gene mutations and their allelic status in myelodysplastic syndromes with isolated 5q deletion.
    4. IFN-gamma induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53.
      Title: IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53.
    5. Targeting mutant p53: a key player in breast cancer pathogenesis and beyond.
      Title: Targeting mutant p53: a key player in breast cancer pathogenesis and beyond.
    6. Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation.
      Title: Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation.
    7. Mutant p53 achieves function by regulating EGR1 to induce epithelial mesenchymal transition.
      Title: Mutant p53 achieves function by regulating EGR1 to induce epithelial mesenchymal transition.
    8. 17p13 (TP53) Deletions Are Associated With an Aggressive Phenotype but Unrelated to Patient Prognosis in Urothelial Bladder Carcinomas.
      Title: 17p13 (TP53) Deletions Are Associated With an Aggressive Phenotype but Unrelated to Patient Prognosis in Urothelial Bladder Carcinomas.
    9. Deciphering Internal Regulatory Patterns within the p53 Core Tetramer: Insights from Community Network Analysis.
      Title: Deciphering Internal Regulatory Patterns within the p53 Core Tetramer: Insights from Community Network Analysis.
    10. CircCFL1 Promotes TNBC Stemness and Immunoescape via Deacetylation-Mediated c-Myc Deubiquitylation to Facilitate Mutant TP53 Transcription.
      Title: CircCFL1 Promotes TNBC Stemness and Immunoescape via Deacetylation-Mediated c-Myc Deubiquitylation to Facilitate Mutant TP53 Transcription.
    Submit: New GeneRIF Correction See all GeneRIFs (9572)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in TP53 that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Associated conditions

    Description Tests
    Adrenocortical carcinoma, hereditary
    MedGen: C1859972 OMIM: 202300 GeneReviews: Not available
    		Compare labs
    Basal cell carcinoma, susceptibility to, 7
    MedGen: C3553606 OMIM: 614740 GeneReviews: Not available
    		Compare labs
    Bone marrow failure syndrome 5
    MedGen: C4748488 OMIM: 618165 GeneReviews: Not available
    		Compare labs
    Bone osteosarcoma
    MedGen: C0585442 OMIM: 259500 GeneReviews: Not available
    		Compare labs
    Carcinoma of pancreas
    MedGen: C0235974 GeneReviews: Not available
    		Compare labs
    Choroid plexus papilloma
    MedGen: C0205770 OMIM: 260500 GeneReviews: Not available
    		Compare labs
    Colorectal cancer
    MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome
    		Compare labs
    Familial cancer of breast
    MedGen: C0346153 OMIM: 114480 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer
    		Compare labs
    Glioma susceptibility 1
    MedGen: C2750850 OMIM: 137800 GeneReviews: Not available
    		Compare labs
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    		Compare labs
    Li-Fraumeni syndrome
    MedGen: C0085390 GeneReviews: Li-Fraumeni Syndrome
    		Compare labs
    Li-Fraumeni syndrome 1
    MedGen: C1835398 OMIM: 151623 GeneReviews: Wilms Tumor Predisposition, Li-Fraumeni Syndrome
    		Compare labs
    Nasopharyngeal carcinoma
    MedGen: C2931822 OMIM: 607107 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2021-11-10)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2021-11-10)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
    EBI GWAS Catalog
    A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
    EBI GWAS Catalog
    Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
    EBI GWAS Catalog
    Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Latent HIV infection increases TP53 (p53) expression and phosphorylation PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 Env gp120 induces TP53 (p53) via binding to the CXCR4 co-receptor PubMed
    env HIV-1 Env gp120 treatment activates TP53 (p53) which contributes to the upregulation of the mitochondrial redox enzyme PRODH (POX) PubMed
    env HIV-1 gp120 is potentially cytotoxic to human cells through the induction of p53, which may eventually lead to induction of apoptosis PubMed
    env Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons PubMed
    env HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53 PubMed
    env Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia PubMed
    env p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41) PubMed
    env Syncytial apoptosis mediated by the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 receptor/coreceptor complex causes phosphorylation of p53 on serine 15 and Bax upregulation PubMed
    Nef nef Assays with phage-displayed Nef from HIV-1 NL4-3 have been used to identify a series of guanidine alkaloid-based inhibitors of Nef interactions with p53, actin, and p56(lck) PubMed
    nef HIV-1 Nef binds directly to tumor suppressor protein p53; an N-terminal 57-residue fragment of Nef (Nef 1-57) contains the p53-binding domain PubMed
    Pr55(Gag) gag HIV-1 infection upregulates the expression of p53 in CD4+ T cells and PBMCs in terms of increased cellular HIV-1 Gag/p24 levels PubMed
    Rev rev HIV-1 Tat reactivates latent HIV-1 proviruses in J1.1 and ACH-2 cell lines and promotes p53-induced apoptosis in the presence of Rev PubMed
    Tat tat Expression of p53 inhibits HIV-1 Tat activity in a dose-dependent manner and PKR plays a crucial role in p53-mediated Tat suppression in p53-/- cells PubMed
    tat Wild-type p53 is a potent inhibitor of HIV-1 Tat transactivation of the HIV-1 LTR promoter in Jurkat T cells and Hep3B cells PubMed
    tat HIV-1 Tat downregulates the expression of p53, suggesting a mechanism for HIV-1-mediated transformation of infected cells PubMed
    tat Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells PubMed
    tat HIV-1 Tat activates the p53 transcription factor pathway leading to the induction of endogenous p53 and p73 in neuronal cells PubMed
    tat HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells PubMed
    tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
    tat HIV-1 Tat reactivates latent HIV-1 proviruses in J1.1 and ACH-2 cell lines and promotes p53-induced apoptosis in the presence of Rev PubMed
    tat The p53 tetramerization domain (residues 326-355) binds directly to residues 1-35 and 47-57 in HIV-1 Tat as evidenced by using peptide mapping, fluorescence anisotropy, and NMR spectroscopy PubMed
    tat In the absence of either p53 or p73, Tat fails to induce dendritic retraction or to activate the proapoptotic proteins, such as Bax PubMed
    tat Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression PubMed
    tat HIV-1 Tat binds to p53, an interaction mediated by the basic region of Tat (amino acids 49-57) and the acidic O2 domain of p53 (amino acids 341-354 PubMed
    tat Supernatants from HIV-1 Tat-transfected monocytoid cells induces p53 expression in neurons, indicating a role for Tat in the neuropathogenesis of HIV-1 PubMed
    tat HIV-1 Tat inhibits p53-responsive transcription by binding to histone acetyltransferases and repressing the acetylation of p53 on residue Lys-320, alluding to a mechanism whereby Tat may impair p53 functions, thus favoring the establishment of neoplasia PubMed
    tat HIV-1 Tat and p53 cooperate in the activation of HIV-1 gene expression in SaOS2 cells PubMed
    Vif vif HIV-1 Vif stabilizes TP53 by blocking MDM2-induced ubiquitination and inhibits MDM2-mediated nuclear export of TP53, leading to support viral replication through inducing G2 cell cycle arrest PubMed
    vif The N-terminal region (residues 1-50) of HIV-1 Vif is important for binding to TP53 PubMed
    Vpr vpr HIV-1 Vpr interacts with p53 in a complex with the transcription factor Sp1 that modulates viral gene transcription from the HIV-1 LTR promoter PubMed
    vpr HIV-1 Vpr downregulates proliferation-associated protein 2G4 (PA2G4) and upregulates p53 in glioblastoma U87MG cells PubMed
    vpr Exposure of cultured human primary astrocytes to HIV-1 Vpr induces p53 up-regulation, loss of mitochondrial membrane potential, and caspase-6 activation followed by cell injury PubMed
    vpr Soluble HIV-1 Vpr causes neuronal apoptosis, involving cytochrome c extravasation, p53 induction, and activation of caspase-9 PubMed
    vpr HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks PubMed
    vpr Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21 PubMed
    vpr Activation of p21/Waf1/Cip1 by HIV-1 Vpr appears to be regulated by p53 PubMed
    vpr HIV-1 Vpr can neutralize inhibitory effects of the human homologue of yeast Rad23 protein A (hHR23A) on p53, thereby activating p53 transcriptional activity PubMed
    vpr Overexpression of p53 decreases the level of activation of the viral LTR promoter by HIV-1 Vpr PubMed
    Vpu vpu HIV-1 Vpu expression results in significant upregulation of phosphorylated p53. Vpu contributes to p53-dependent apoptosis in HIV-1-infected cells PubMed
    vpu HIV-1 Vpu expression leads to stabilization and upregulation of p53 via inhibiting association of p53 with beta-TrCP and its subsequent ubiquitination PubMed
    integrase gag-pol HIV-1 IN-mediated proviral DNA integration triggers cell death during HIV-1 infection. The mechanism of killing during viral integration involves activation of DNA-PK, which causes phosphorylation of p53 and histone gammaH2AX PubMed
    reverse transcriptase gag-pol Tumor suppressor protein p53 displays 3' --> 5' exonuclease activity, and interaction of p53 with HIV-1 reverse transcriptase (RT) can provide a proofreading function for HIV-1 RT PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ92943

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ATP-dependent DNA/DNA annealing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MDM2/MDM4 family protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables TFIID-class transcription factor complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables general transcription initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone deacetylase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular function activator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables molecular function activator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 2A binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ER overload response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in T cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in T cell proliferation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bone marrow development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cardiac septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to UV-C IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to actinomycin D IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to gamma radiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in determination of adult lifespan ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gastrulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose catabolic process to lactate via pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic G1 DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in necroptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of G1 to G0 transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of G1 to G0 transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of glucose catabolic process to lactate via pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of helicase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of miRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mitophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of pentose-phosphate shunt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligodendrocyte apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oxidative stress-induced premature senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cellular senescence IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cellular senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of miRNA transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of miRNA transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of miRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of miRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial membrane permeability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of programmed necrotic cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of thymocyte apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA damage response, signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_negative_effect regulation of cell cycle G2/M phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of fibroblast apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrial membrane permeability involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replicative senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to X-ray IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to salt stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thymocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in type II interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in replication fork IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of transcription repressor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cellular tumor antigen p53
    Names
    antigen NY-CO-13
    mutant tumor protein 53
    phosphoprotein p53
    transformation-related protein 53
    tumor protein 53
    tumor supressor p53

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017013.2 RefSeqGene

      Range
      5001..24149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_321

    mRNA and Protein(s)

    1. NM_000546.6 → NP_000537.3  cellular tumor antigen p53 isoform a

      See identical proteins and their annotated locations for NP_000537.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (a, also known as p53alpha) results from translation initiation at the upstream start codon. Both variants 1 and 2 encode isoform a, which is the longest isoform.
      Source sequence(s)
      AK223026, DA453049, X02469
      Consensus CDS
      CCDS11118.1
      UniProtKB/Swiss-Prot
      P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61
      UniProtKB/TrEMBL
      A0A386NC20, A0A386NC22, A0A386NC55, A0A386NC62, A0A386NCA6, A0A386NCB1, A0A386NCU2, A0A386NCW8, A0A386NCX4, A0A386NDA8, A0A386NDB3, A0A386NFX3, A0A386NFY2, A0A386NG45, K7PPA8, K7PPU4
      Related
      ENSP00000269305.4, ENST00000269305.9
      Conserved Domains (4) summary
      cd08367
      Location:109 → 288
      P53; P53 DNA-binding domain
      pfam18521
      Location:35 → 59
      TAD2; Transactivation domain 2
      pfam07710
      Location:319 → 355
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:6 → 30
      P53_TAD; P53 transactivation motif

    2. NM_001126112.3 → NP_001119584.1  cellular tumor antigen p53 isoform a

      See identical proteins and their annotated locations for NP_001119584.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS11118.1
      UniProtKB/Swiss-Prot
      P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61
      UniProtKB/TrEMBL
      A0A386NC20, A0A386NC22, A0A386NC55, A0A386NC62, A0A386NCA6, A0A386NCB1, A0A386NCU2, A0A386NCW8, A0A386NCX4, A0A386NDA8, A0A386NDB3, A0A386NFX3, A0A386NFY2, A0A386NG45, K7PPA8, K7PPU4
      Related
      ENSP00000391478.2, ENST00000445888.6
      Conserved Domains (4) summary
      cd08367
      Location:109 → 288
      P53; P53 DNA-binding domain
      pfam18521
      Location:35 → 59
      TAD2; Transactivation domain 2
      pfam07710
      Location:319 → 355
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:6 → 30
      P53_TAD; P53 transactivation motif

    3. NM_001126113.3 → NP_001119585.1  cellular tumor antigen p53 isoform c

      See identical proteins and their annotated locations for NP_001119585.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS45605.1
      UniProtKB/TrEMBL
      A0A223PQI5
      Related
      ENSP00000398846.2, ENST00000455263.6
      Conserved Domains (2) summary
      pfam00870
      Location:95 → 289
      P53; P53 DNA-binding domain
      pfam08563
      Location:5 → 28
      P53_TAD; P53 transactivation motif

    4. NM_001126114.3 → NP_001119586.1  cellular tumor antigen p53 isoform b

      See identical proteins and their annotated locations for NP_001119586.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS45606.1
      UniProtKB/TrEMBL
      J3KP33
      Related
      ENSP00000391127.2, ENST00000420246.6
      Conserved Domains (2) summary
      pfam00870
      Location:95 → 289
      P53; P53 DNA-binding domain
      pfam08563
      Location:5 → 28
      P53_TAD; P53 transactivation motif

    5. NM_001126115.2 → NP_001119587.1  cellular tumor antigen p53 isoform d

      See identical proteins and their annotated locations for NP_001119587.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS73966.1
      UniProtKB/TrEMBL
      E9PFT5
      Related
      ENSP00000481179.1, ENST00000504937.5
      Conserved Domains (2) summary
      pfam07710
      Location:187 → 226
      P53_tetramer; P53 tetramerization motif
      cl14608
      Location:1 → 157
      P53; P53 DNA-binding domain

    6. NM_001126116.2 → NP_001119588.1  cellular tumor antigen p53 isoform e

      See identical proteins and their annotated locations for NP_001119588.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS73968.1
      UniProtKB/TrEMBL
      E7ESS1
      Related
      ENSP00000478499.1, ENST00000510385.5
      Conserved Domains (1) summary
      cl14608
      Location:1 → 157
      P53; P53 DNA-binding domain

    7. NM_001126117.2 → NP_001119589.1  cellular tumor antigen p53 isoform f

      See identical proteins and their annotated locations for NP_001119589.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS73967.1
      UniProtKB/TrEMBL
      E7ESS1
      Related
      ENSP00000484409.1, ENST00000504290.5
      Conserved Domains (1) summary
      cl14608
      Location:1 → 157
      P53; P53 DNA-binding domain

    8. NM_001126118.2 → NP_001119590.1  cellular tumor antigen p53 isoform g

      See identical proteins and their annotated locations for NP_001119590.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS73969.1
      UniProtKB/TrEMBL
      H2EHT1, K7PPU4
      Related
      ENSP00000478219.1, ENST00000610292.4
      Conserved Domains (2) summary
      pfam00870
      Location:56 → 250
      P53; P53 DNA-binding domain
      pfam07710
      Location:280 → 319
      P53_tetramer; P53 tetramerisation motif

    9. NM_001276695.3 → NP_001263624.1  cellular tumor antigen p53 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional exon in the 3' coding region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (h, also known as delta40p53gamma) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK223026, DA453049, DQ186649
      Consensus CDS
      CCDS73970.1
      UniProtKB/TrEMBL
      A0A223PQI5
      Related
      ENSP00000480868.1, ENST00000610538.4
      Conserved Domains (1) summary
      pfam00870
      Location:56 → 250
      P53; P53 DNA-binding domain

    10. NM_001276696.3 → NP_001263625.1  cellular tumor antigen p53 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional exon in the 3' region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (i, also known as delta40p53beta) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK223026, DA453049, DQ186648, DQ186649
      Consensus CDS
      CCDS73971.1
      UniProtKB/TrEMBL
      J3KP33
      Related
      ENSP00000482222.1, ENST00000622645.4
      Conserved Domains (1) summary
      pfam00870
      Location:56 → 250
      P53; P53 DNA-binding domain

    11. NM_001276697.3 → NP_001263626.1  cellular tumor antigen p53 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (j, also known as delta160p53alpha) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AK223026, DQ186650
      Consensus CDS
      CCDS73963.1
      UniProtKB/TrEMBL
      A0A087X1Q1
      Related
      ENSP00000484375.1, ENST00000619186.4
      Conserved Domains (2) summary
      pfam07710
      Location:160 → 199
      P53_tetramer; P53 tetramerisation motif
      cl14608
      Location:1 → 130
      P53; P53 DNA-binding domain

    12. NM_001276698.3 → NP_001263627.1  cellular tumor antigen p53 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (k, also known as delta160p53beta) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AK223026, DQ186651
      Consensus CDS
      CCDS73965.1
      UniProtKB/TrEMBL
      A0A087WXZ1, E7ESS1
      Related
      ENSP00000481401.1, ENST00000618944.4
      Conserved Domains (1) summary
      cl14608
      Location:1 → 130
      P53; P53 DNA-binding domain

    13. NM_001276699.3 → NP_001263628.1  cellular tumor antigen p53 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (l, also known as delta160p53gamma) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AK223026, DQ186652
      Consensus CDS
      CCDS73964.1
      UniProtKB/TrEMBL
      A0A087WT22, E7ESS1
      Related
      ENSP00000477531.1, ENST00000610623.4
      Conserved Domains (1) summary
      cl14608
      Location:1 → 130
      P53; P53 DNA-binding domain

    14. NM_001276760.3 → NP_001263689.1  cellular tumor antigen p53 isoform g

      See identical proteins and their annotated locations for NP_001263689.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (g, also known as delta40p53alpha or deltaNp53) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. Variants 1, 2, and 8 encode isoform g.
      Source sequence(s)
      AK223026, DA453049, X02469
      Consensus CDS
      CCDS73969.1
      UniProtKB/TrEMBL
      H2EHT1, K7PPU4
      Related
      ENSP00000481638.1, ENST00000620739.4
      Conserved Domains (2) summary
      pfam00870
      Location:56 → 250
      P53; P53 DNA-binding domain
      pfam07710
      Location:280 → 319
      P53_tetramer; P53 tetramerisation motif

    15. NM_001276761.3 → NP_001263690.1  cellular tumor antigen p53 isoform g

      See identical proteins and their annotated locations for NP_001263690.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (g, also known as delta40p53alpha or deltaNp53) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. Variants 1, 2, and 8 encode isoform g.
      Source sequence(s)
      AB082923, AK223026, DA453049, X02469
      Consensus CDS
      CCDS73969.1
      UniProtKB/TrEMBL
      H2EHT1, K7PPU4
      Related
      ENSP00000482537.1, ENST00000619485.4
      Conserved Domains (2) summary
      pfam00870
      Location:56 → 250
      P53; P53 DNA-binding domain
      pfam07710
      Location:280 → 319
      P53_tetramer; P53 tetramerisation motif

    16. NM_001407262.1 → NP_001394191.1  cellular tumor antigen p53 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      UniProtKB/Swiss-Prot
      P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61
      UniProtKB/TrEMBL
      K7PPA8
      Related
      ENSP00000426252.2, ENST00000503591.2

    17. NM_001407263.1 → NP_001394192.1  cellular tumor antigen p53 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      UniProtKB/TrEMBL
      H2EHT1

    18. NM_001407264.1 → NP_001394193.1  cellular tumor antigen p53 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      UniProtKB/Swiss-Prot
      P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61
      UniProtKB/TrEMBL
      K7PPA8

    19. NM_001407265.1 → NP_001394194.1  cellular tumor antigen p53 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      UniProtKB/TrEMBL
      H2EHT1

    20. NM_001407266.1 → NP_001394195.1  cellular tumor antigen p53 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      UniProtKB/Swiss-Prot
      P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61
      UniProtKB/TrEMBL
      K7PPA8
      Related
      ENSP00000424104.2, ENST00000508793.6

    21. NM_001407267.1 → NP_001394196.1  cellular tumor antigen p53 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      UniProtKB/TrEMBL
      H2EHT1

    22. NM_001407268.1 → NP_001394197.1  cellular tumor antigen p53 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Related
      ENSP00000352610.4, ENST00000359597.8

    23. NM_001407269.1 → NP_001394198.1  cellular tumor antigen p53 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388

    24. NM_001407270.1 → NP_001394199.1  cellular tumor antigen p53 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388

    25. NM_001407271.1 → NP_001394200.1  cellular tumor antigen p53 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388

    RNA

    1. NR_176326.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Related
      ENST00000714358.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      7668421..7687490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      7572544..7591594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04637.4 GenPept UniProtKB/Swiss-Prot:P04637

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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