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Carcinoma of pancreas

MedGen UID:
65917
•Concept ID:
C0235974
•
Neoplastic Process
Synonyms: Exocrine pancreatic carcinoma; PANCREATIC ACINAR CARCINOMA; Pancreatic cancer, somatic; PANCREATIC CARCINOMA; Pancreatic carcinoma, somatic
SNOMED CT: Carcinoma of pancreas (372142002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Genes (locations): ACVR1B (12q13.13); KRAS (12p12.1); SMAD4 (18q21.2); STK11 (19p13.3); TP53 (17p13.1)
 
Monarch Initiative: MONDO:0005192
OMIM®: 260350
Orphanet: ORPHA217074

Definition

A carcinoma arising from the exocrine pancreas. The overwhelming majority of pancreatic carcinomas are adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Carcinoma of pancreas in Orphanet.

Professional guidelines

PubMed

Efficacy of carcinogenic embryonic antigen in differential diagnosis of diseases of pancreas and liver--a comparative study in a tertiary care hospital of Western Nepal.
Mittal A, Farooqui SM, Pyrtuh S, Poudel B, Sathian B, Yadav SK
Asian Pac J Cancer Prev 2012;13(1):275-7. doi: 10.7314/apjcp.2012.13.1.275. PMID: 22502684
Evaluation & management of clinically labeled carcinoma head of the pancreas--a prospective study of 60 patients.
Ali M, Zafar SM, Das BC, Rabbi H, Fazal NM, Roy S, Imam NA, Islam MM
Bangladesh Med Res Counc Bull 2003 Apr;29(1):29-37. PMID: 14674618
Influence of multimodality therapy on the management of pancreas carcinoma.
Jessup JM, Posner M, Huberman M
Semin Surg Oncol 1993 Jan-Feb;9(1):27-32. doi: 10.1002/ssu.2980090106. PMID: 8356381

Curated

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Recent clinical studies

Etiology

Gut microbiota and pancreatic cancer risk, and the mediating role of immune cells and inflammatory cytokines: a Mendelian randomization study.
Chen Z, Wang Z, Bao H, Ma S
Front Immunol 2024;15:1408770. Epub 2024 Jul 25 doi: 10.3389/fimmu.2024.1408770. PMID: 39119339Free PMC Article
A case of primary squamous cell carcinoma of the pancreas with gastric invasion, and a review of the literature.
Chen J, Wang C, Ma R, Wan S, Wang B
Ann Ital Chir 2023 Mar 6;12 PMID: 36924068
Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs.
Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS
Clin Exp Rheumatol 2022 May;40(5):913-920. Epub 2021 Jul 24 doi: 10.55563/clinexprheumatol/o3rgv1. PMID: 34369368
Adenosquamous carcinoma of pancreas: CT and MR imaging features in eight patients, with pathologic correlations and comparison with adenocarcinoma of pancreas.
Toshima F, Inoue D, Yoshida K, Yoneda N, Minami T, Kobayashi S, Ikdeda H, Matsui O, Gabata T
Abdom Radiol (NY) 2016 Mar;41(3):508-20. doi: 10.1007/s00261-015-0616-4. PMID: 27039322
The current status of preoperative biliary drainage for patients who receive pancreaticoduodenectomy for periampullary carcinoma: a comprehensive review.
Lai EC, Lau SH, Lau WY
Surgeon 2014 Oct;12(5):290-6. Epub 2014 Mar 17 doi: 10.1016/j.surge.2014.02.004. PMID: 24650759

Diagnosis

Anaplastic (undifferentiated) carcinoma of pancreas, an uncommon variant: Diagnosed on endoscopic-guided fine needle aspiration.
Osama MA, Bakshi P, Verma K
Indian J Pathol Microbiol 2023 Jul-Sep;66(3):648-651. doi: 10.4103/ijpm.ijpm_538_21. PMID: 37530362
A case of primary squamous cell carcinoma of the pancreas with gastric invasion, and a review of the literature.
Chen J, Wang C, Ma R, Wan S, Wang B
Ann Ital Chir 2023 Mar 6;12 PMID: 36924068
Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs.
Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS
Clin Exp Rheumatol 2022 May;40(5):913-920. Epub 2021 Jul 24 doi: 10.55563/clinexprheumatol/o3rgv1. PMID: 34369368
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Unusual Case of Squamous Cell Carcinoma of Pancreas with Review of Literature.
Mehta M, Sinha J, Ogawa M, Ganguly A, Xiang D, Poddar N
J Gastrointest Cancer 2015 Dec;46(4):426-9. doi: 10.1007/s12029-015-9712-5. PMID: 25894633

Therapy

Gut microbiota and pancreatic cancer risk, and the mediating role of immune cells and inflammatory cytokines: a Mendelian randomization study.
Chen Z, Wang Z, Bao H, Ma S
Front Immunol 2024;15:1408770. Epub 2024 Jul 25 doi: 10.3389/fimmu.2024.1408770. PMID: 39119339Free PMC Article
Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs.
Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS
Clin Exp Rheumatol 2022 May;40(5):913-920. Epub 2021 Jul 24 doi: 10.55563/clinexprheumatol/o3rgv1. PMID: 34369368
4H12, a Murine Monoclonal Antibody Directed against Myosin Heavy Chain-9 Expressed on Acinar Cell Carcinoma of Pancreas with Potential Therapeutic Application.
Balouchi-Anaraki S, Ahmadvand S, Safaei A, Ghaderi A
Iran Biomed J 2021 Sep 1;25(5):310-22. doi: 10.52547/ibj.25.5.310. [Epub ahead of print] PMID: 34425650Free PMC Article
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
The current status of preoperative biliary drainage for patients who receive pancreaticoduodenectomy for periampullary carcinoma: a comprehensive review.
Lai EC, Lau SH, Lau WY
Surgeon 2014 Oct;12(5):290-6. Epub 2014 Mar 17 doi: 10.1016/j.surge.2014.02.004. PMID: 24650759

Prognosis

Anaplastic (undifferentiated) carcinoma of pancreas, an uncommon variant: Diagnosed on endoscopic-guided fine needle aspiration.
Osama MA, Bakshi P, Verma K
Indian J Pathol Microbiol 2023 Jul-Sep;66(3):648-651. doi: 10.4103/ijpm.ijpm_538_21. PMID: 37530362
A case of primary squamous cell carcinoma of the pancreas with gastric invasion, and a review of the literature.
Chen J, Wang C, Ma R, Wan S, Wang B
Ann Ital Chir 2023 Mar 6;12 PMID: 36924068
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Unusual Case of Squamous Cell Carcinoma of Pancreas with Review of Literature.
Mehta M, Sinha J, Ogawa M, Ganguly A, Xiang D, Poddar N
J Gastrointest Cancer 2015 Dec;46(4):426-9. doi: 10.1007/s12029-015-9712-5. PMID: 25894633
Pancreatic carcinoma.
Ajao OG, Abioye AA
J Natl Med Assoc 1980 Jun;72(6):589-90. PMID: 7392077Free PMC Article

Clinical prediction guides

Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs.
Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS
Clin Exp Rheumatol 2022 May;40(5):913-920. Epub 2021 Jul 24 doi: 10.55563/clinexprheumatol/o3rgv1. PMID: 34369368
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Immunological mutational signature in adenosquamous cancer of pancreas: an exploratory study of potentially therapeutic targets.
Silvestris N, Brunetti O, Pinto R, Petriella D, Argentiero A, Fucci L, Tommasi S, Danza K, De Summa S
Expert Opin Ther Targets 2018 May;22(5):453-461. Epub 2018 Mar 27 doi: 10.1080/14728222.2018.1456530. PMID: 29561217
A case report of bilateral choroidal metastases of epithelial carcinoma of pancreas.
Bilgin AB, Apaydin KC, Unal M, Ilhan HD, Turkoglu EB, Aydin N
Arq Bras Oftalmol 2014 Aug;77(4):259-60. doi: 10.5935/0004-2749.20140065. PMID: 25410180
Relative frequency and morphology of cancers in carriers of germline TP53 mutations.
Birch JM, Alston RD, McNally RJ, Evans DG, Kelsey AM, Harris M, Eden OB, Varley JM
Oncogene 2001 Aug 2;20(34):4621-8. doi: 10.1038/sj.onc.1204621. PMID: 11498785

Supplemental Content

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    Curated

    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
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    • GTR
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      Clinical tests in GTR
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    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
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