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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 03, 2009 |
| Title |
Gene expression data from mouse hematopoietic cells, Ikaros wt and null mutant |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Regulation of lineage potential and transcriptional priming by Ikaros. New insight is provided into a bivalent regulation of lineage priming in the HSC and its lympho-myeloid restricted progeny the LMPP by the lymphoid lineage-determining factor Ikaros
Whereas Ikaros is responsible for the activation of a cascade of lymphoid expression programs and for the establishment of lymphoid potential from the HSC to the LMPP it is also responsible for the repression of stem cell and erythroid genetic programs that are incompatible with further lineage restrictions emanating from the LMPP
Keywords: Ikaros null versus wt
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| Overall design |
Ikaros null versus wt
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| Contributor(s) |
Ng S, Yoshida T, Zhang J, Georgopoulos K |
| Citation(s) |
19345118 |
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| Submission date |
Mar 21, 2009 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Jiangwen Zhang |
| E-mail(s) |
jzhang@cgr.harvard.edu
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| Organization name |
Harvard University
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| Department |
FAS Center for Systems Biology
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| Street address |
7 Divinity Ave
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| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02138 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (27)
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| GSM385193 |
WT LSK GFPhi, biological rep1 |
| GSM385194 |
WT LSK GFPhi, biological rep2 |
| GSM385195 |
WT LSK GFPhi, biological rep3 |
| GSM385196 |
WT LK GFPneg, biological rep1 |
| GSM385197 |
WT LK GFPneg, biological rep2 |
| GSM385198 |
WT LK GFPneg, biological rep3 |
| GSM385199 |
WT LK GFPhi, biological rep1 |
| GSM385200 |
WT LK GFPhi, biological rep2 |
| GSM385201 |
WT LK GFPhi, biological rep3 |
| GSM385202 |
WT ProB, biological rep1 |
| GSM385203 |
WT ProB, biological rep2 |
| GSM385204 |
WT ProB, biological rep3 |
| GSM385205 |
KO LSK GFPneg-lo, biological rep1 |
| GSM385206 |
KO LSK GFPneg-lo, biological rep2 |
| GSM385207 |
KO LSK GFPneg-lo, biological rep3 |
| GSM385208 |
KO LSK GFPhi, biological rep1 |
| GSM385209 |
KO LSK GFPhi, biological rep2 |
| GSM385210 |
KO LSK GFPhi, biological rep3 |
| GSM385211 |
KO LK GFPneg, biological rep1 |
| GSM385212 |
KO LK GFPneg, biological rep2 |
| GSM385213 |
KO LK GFPneg, biological rep3 |
| GSM385214 |
KO LK GFPhi, biological rep1 |
| GSM385215 |
KO LK GFPhi, biological rep2 |
| GSM385216 |
KO LK GFPhi, biological rep3 |
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| Relations |
| BioProject |
PRJNA116559 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE15330_RAW.tar |
107.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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