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Series GSE181253 Query DataSets for GSE181253
Status Public on Sep 02, 2021
Title The potent and selective RIPK2 inhibitor BI 706039 improves intestinal inflammation in the TRUC mouse model of Inflammatory Bowel Disease
Organism Mus musculus
Experiment type Other
Summary Mouse distal colons were preserved snap frozen in RNAlater, homogenized in Trizol Reagent. A total of 100 ng of RNA per sample were used for hybridization and run on the XT_PGX_MmV2_Inflammation_CSO 248 gene panel for multiplexed semi-quantitative analysis of colonic RNA markers of inflammation.
 
Overall design Gene expression of TRUC mice treated with the anti-p40 monoclonal antibody and the BI 706039, and their relative controls, were analyzed from the customized 248 mouse gene Nanostring panel. The raw counts from Ncounter were normalized to housekeeping gene, GAPDH, then log2 transformed, followed by non-parametric T-test with homes-Bonferroni adjustment. T
 
Contributor(s) Li LL
Citation(s) 34494462
Submission date Jul 31, 2021
Last update date Dec 03, 2021
Contact name Li Li
E-mail(s) frank.li@boehringer-ingelheim.com
Organization name Boehringer Ingelheim Pharmaceuticals, Inc.
Street address PO Box 368
City Ridgefield
State/province Connecticut
ZIP/Postal code 06877-0368
Country USA
 
Platforms (1)
GPL20885 nCounter Mouse Inflammation panel V2
Samples (24)
GSM5493604 118 DC
GSM5493605 126 DC
GSM5493606 127 DC
Relations
BioProject PRJNA751225

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE181253_raw_data.txt.gz 14.4 Kb (ftp)(http) TXT
Processed data included within Sample table

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