|
| Status |
Public on Aug 25, 2010 |
| Title |
Effects of ACE2 on BMPR2 mutation-mediated defects in gene expression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
BMPR2 mutation causes pulmonary arterial hypertension (PAH); ACE2 treatment can resolve established BMPR2-mediated PAH. The purpose of this study was to uncover the molecular mechanism behind this.
|
| |
|
| Overall design |
Four groups: +/- ACE2 and +/- BMPR2 transgene, two arrays each, each array a pool of three animals.
|
| |
|
| Contributor(s) |
Johnson J, West J |
| Citation(s) |
22180660 |
| |
| Submission date |
Apr 28, 2010 |
| Last update date |
Feb 11, 2019 |
| Contact name |
James West |
| E-mail(s) |
j.west@vanderbilt.edu
|
| Organization name |
Vanderbilt University
|
| Department |
Medicine
|
| Lab |
Pulmonary
|
| Street address |
4200 E 9TH Ave, Box B133
|
| City |
Nashville |
| State/province |
TN |
| ZIP/Postal code |
37201 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (8)
|
| GSM538878 |
Control mouse + chronic ACE2 lung (2) |
| GSM538879 |
Rosa26-BMPR2-R899X mouse + chronic ACE2 lung (1) |
| GSM538880 |
Rosa26-BMPR2-R899X mouse + chronic ACE2 lung (2) |
| GSM538881 |
Rosa26-BMPR2-R899X lung (1) |
| GSM538882 |
Rosa26-BMPR2-R899X lung (2) |
|
| Relations |
| BioProject |
PRJNA127021 |
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