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Series GSE217483 Query DataSets for GSE217483
Status Public on Dec 22, 2022
Title Single-nucleus transcriptomic profiling of multiple organs from rhesus macaque model with SARS-CoV-2 infection
Organism Macaca mulatta
Experiment type Expression profiling by high throughput sequencing
Summary Here we profiled about 77000 single-nucleus transcriptomes of lung, liver, kidney, and cerebral cortex from rhesus macaques infected with SARS-CoV-2. Our work of multi-organ single-nucleus transcriptomic survey of SARS-CoV-2 infected animal model expanded our understanding of disease features and antiviral immune defects caused by the novel coronavirus at cellular and molecular level, which may facilitate the development of potential therapeutic intervention for COVID-19.
Overall design Single-nucleus RNA-seq with lung, liver, kidney, cerebral cortex from two infected macaques as well as one or two healthy control. 10X Genomics platform was applied.
Contributor(s) Ma Q, Song T, Liu Z, Ma W, Wu Q, Yao Y, Zheng Y, Wang X
Citation(s) 36349357
Submission date Nov 07, 2022
Last update date Dec 25, 2022
Contact name Qiang Ma
Organization name Institute of Biophysics, Chinese Academy of Sciences
Street address Datun Road, #15
City Beijing
ZIP/Postal code 100101
Country China
Platforms (1)
GPL27943 Illumina NovaSeq 6000 (Macaca mulatta)
Samples (15)
GSM6720283 healthy, lung, ctrl1
GSM6720284 healthy, liver, ctrl1
GSM6720285 healthy, kidney, ctrl1
BioProject PRJNA899099

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Supplementary file Size Download File type/resource
GSE217483_Macaca_global_integration.h5ad.gz 280.4 Mb (ftp)(http) H5AD
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