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Series GSE244304 Query DataSets for GSE244304
Status Public on Oct 03, 2023
Title Myeloid Cell Derived IL1b Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection Fraction
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Goals and objectives of this study were to determine by bulk RNA-sequencing transcriptomic changes that occur in the lungs of a murine model of heart failure with preserved ejection fraction caused by administration of high fat diet and eNOS inhibitor L-NAME.
Overall design Four C57/BL6 mice each were given either a combination of high fat diet and L-NAME or control (low fat diet with no L-NAME) for 5 weeks. Lungs were isolated after sacrifice, enzymatically digested, separately labeled with hashing antibodies, and submitted for single cell RNA sequencing.
Contributor(s) Agrawal V, West J
Citation(s) 37929582
Submission date Sep 28, 2023
Last update date Jan 02, 2024
Contact name James West
Organization name Vanderbilt University
Department Medicine
Lab Pulmonary
Street address 4200 E 9TH Ave, Box B133
City Nashville
State/province TN
ZIP/Postal code 37201
Country USA
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (12)
GSM7813214 2-week LNAME/HFD - 2524
GSM7813215 2-week LNAME/HFD - 2526
GSM7813216 2-week LNAME/HFD - 2528
BioProject PRJNA1022149

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE244304_LNAME_Mice_Normalized_counts.txt.gz 1.5 Mb (ftp)(http) TXT
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Processed data are available on Series record

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