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Series GSE31647 Query DataSets for GSE31647
Status Public on Dec 05, 2011
Title Nicotinamide mononucleotide, a key NAD+ precursor, treats the pathophysiology of diet- and age-induced diabetes
Organism Mus musculus
Experiment type Expression profiling by array
Summary Type 2 diabetes (T2D) has become an epidemic in our modern lifestyle, likely due to calorie-rich diets overwhelming our adaptive metabolic pathways. One such pathway is mediated by nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in mammalian NAD+ biosynthesis, and the NAD+-dependent protein deacetylase SIRT1. Here we show that NAMPT-mediated NAD+ biosynthesis is severely compromised in metabolic organs by high-fat diet (HFD). Strikingly, nicotinamide mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. Furthermore, NAD+ and NAMPT levels show significant decreases in multiple organs during aging, and NMN improves glucose intolerance and lipid profiles in age-induced T2D mice. These findings provide critical insights into a novel intervention against diet- and age-induced T2D.
 
Overall design 4 regular chow fed mice (RC1-4) vs 4 high-fat diet fed (HFD) (HFD1a-4a) mice were analyzed on one chip (Chip-A). 4 HFD mice (HFD1b-4b) vs 4 HFD-NMN treated mice (NMN1-4) were examined on the other chip (Chip-B).
 
Contributor(s) Yoshino J, Imai S, Mills KF, Yoon MJ
Citation(s)
  • Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab 2011 Oct 5;14(4):528-36. PMID: 21982712
Submission date Aug 25, 2011
Last update date Sep 15, 2023
Contact name Jun Yoshino
E-mail(s) jyoshino@med.shimane-u.ac.jp
Organization name Faculty of Medicine, Shimane University
Street address 89-1 Enya-cho
City Izumo
State/province Shimane
ZIP/Postal code 693-8501
Country Japan
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (16)
GSM785915 RC1
GSM785916 RC2
GSM785917 RC3
Relations
BioProject PRJNA145417

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE31647_RAW.tar 3.1 Mb (http)(custom) TAR
GSE31647_non-normalized.txt.gz 2.6 Mb (ftp)(http) TXT
Processed data included within Sample table

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