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| Status |
Public on Jan 04, 2016 |
| Title |
Comprehensive transcriptome profiling reveals multigene signatures in triple negative breast cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To develop and validate novel multigene signatures to facilitate individualized treatment of TNBC patients By integrating expression profiles of messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs).
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| Overall design |
We analysed 165 TNBC samples and 33 paired normal breast tissues using transcriptome microarrays. Tumor-specific mRNAs and lncRNAs were identified and correlated with patients’ recurrence-free survival (RFS). Using Cox regression model, we built two multigene signatures incorporating mRNAs and lncRNAs. The prognostic and predictive accuracy of the signatures were tested in a training set of 165 TNBC patients and validated in another 101 TNBC patients.
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| Contributor(s) |
Liu Y, Jiang Y, Xu X, Hu X, Yu K, Shao Z |
| Citation(s) |
26813360, 26921339, 34615706 |
| Submission date |
Dec 22, 2015 |
| Last update date |
Oct 27, 2021 |
| Contact name |
Yi-Zhou Jiang |
| E-mail(s) |
yizhoujiang@fudan.edu.cn
|
| Phone |
+8615921910483
|
| Organization name |
Fudan University Shanghai Cancer Center
|
| Street address |
No. 270 Dong-An Road
|
| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
| |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (198)
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| Relations |
| BioProject |
PRJNA306725 |
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