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| Status |
Public on Nov 29, 2016 |
| Title |
Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb and paraquat-induced model of Parkinson's disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Altogether results show that peroxidase activity of cytochrome c contributes to α-synuclein radical formation and oligomerization, and that α-synuclein through its co-localization with cytochrome c or on it's own, affects several biological pathways which contribute to increased neuronal death in Maneb and paraquat (MP)-induced model of Parkinson's disease.
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| |
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| Overall design |
Nigrostriatal tissue of Controls, Wild-Type MP co-exposed mice, and MP-coexposed α-synuclein Knock out mice, were analysed by Microarray with three replicates for each group.
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| |
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| Contributor(s) |
Kumar A, Ganini D, Mason RP |
| Citation(s) |
27884192 |
| |
| Submission date |
Nov 04, 2016 |
| Last update date |
May 10, 2018 |
| Contact name |
NIEHS Microarray Core |
| E-mail(s) |
microarray@niehs.nih.gov, liuliw@niehs.nih.gov
|
| Organization name |
NIEHS
|
| Department |
DIR
|
| Lab |
Microarray Core
|
| Street address |
111 T.W. Alexander Drive
|
| City |
RTP |
| State/province |
NC |
| ZIP/Postal code |
27709 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA352558 |
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