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Benign neoplasm of pharynx

MedGen UID:
102296
•Concept ID:
C0153940
•
Neoplastic Process
Synonyms: Benign Neoplasm of Pharynx; benign neoplasm of pharynx; Benign Neoplasm of the Pharynx; benign neoplasm of the pharynx; Benign Pharyngeal Neoplasm; benign pharyngeal neoplasm; Benign Pharyngeal Tumor; benign pharyngeal tumor; benign pharyngeal tumour; Benign Pharynx Neoplasm; benign pharynx neoplasm; Benign Pharynx Tumor; benign pharynx tumor; benign pharynx tumour; Benign Tumor of Pharynx; benign tumor of pharynx; Benign Tumor of the Pharynx; benign tumor of the pharynx; benign tumour of pharynx; benign tumour of the pharynx; Pharyngeal Neoplasm Benign; pharyngeal neoplasm benign; pharynx benign neoplasm
SNOMED CT: Benign neoplasm of pharynx (92293007)
 
Monarch Initiative: MONDO:0021523

Definition

A neoplasm that arises from the pharynx and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma.
Grégoire V, Grau C, Lapeyre M, Maingon P
Oral Oncol 2018 Dec;87:131-137. Epub 2018 Nov 3 doi: 10.1016/j.oraloncology.2018.10.034. PMID: 30527228
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406

Recent clinical studies

Etiology

Case series report: radiation-induced oropharyngeal carcinoma.
Salman S, Doweck I, Taha T, Billan S
Anticancer Drugs 2023 Feb 1;34(2):325-331. Epub 2022 Nov 15 doi: 10.1097/CAD.0000000000001411. PMID: 36730617
Tonsillectomy and the incidence of various types of cancer.
Holló G
Immunol Res 2021 Dec;69(6):467-470. Epub 2021 Sep 15 doi: 10.1007/s12026-021-09230-3. PMID: 34523058Free PMC Article
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma.
Grégoire V, Grau C, Lapeyre M, Maingon P
Oral Oncol 2018 Dec;87:131-137. Epub 2018 Nov 3 doi: 10.1016/j.oraloncology.2018.10.034. PMID: 30527228
Complications After Endoscopic Laryngopharyngeal Surgery.
Kishimoto Y, Sogami T, Uozumi R, Funakoshi M, Miyamoto SI, Kitamura M, Suzuki C, Muto M, Tateya I, Omori K
Laryngoscope 2018 Jul;128(7):1546-1550. Epub 2017 Oct 10 doi: 10.1002/lary.26953. PMID: 28994120

Diagnosis

Case series report: radiation-induced oropharyngeal carcinoma.
Salman S, Doweck I, Taha T, Billan S
Anticancer Drugs 2023 Feb 1;34(2):325-331. Epub 2022 Nov 15 doi: 10.1097/CAD.0000000000001411. PMID: 36730617
Primary nasopharyngeal tuberculosis.
Misirovs R, Johnston L, Green R
BMJ Case Rep 2022 Dec 7;15(12) doi: 10.1136/bcr-2022-251927. PMID: 36593611Free PMC Article
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590

Therapy

Tonsillectomy and the incidence of various types of cancer.
Holló G
Immunol Res 2021 Dec;69(6):467-470. Epub 2021 Sep 15 doi: 10.1007/s12026-021-09230-3. PMID: 34523058Free PMC Article
Cancer of the Larynx and Hypopharynx.
Echanique KA, Evans LK, Han AY, Chhetri DK, St John MA
Hematol Oncol Clin North Am 2021 Oct;35(5):933-947. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.005. PMID: 34272102
Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients: 2021 update.
Patel P, Robinson PD, Baggott C, Gibson P, Ljungman G, Massey N, Ottaviani G, Phillips R, Revon-Rivière G, Treister N, White M, Cabral S, Dupuis L, Sung L
Eur J Cancer 2021 Sep;154:92-101. Epub 2021 Jul 9 doi: 10.1016/j.ejca.2021.05.013. PMID: 34252760
History of tonsillectomy and risk of oropharyngeal cancer.
Combes JD, Voisin N, Périé S, Malard O, Jegoux F, Nadjingar R, Buiret G, Philouze P, Garrel R, Vergez S, Fakhry N, Righini C, Mirghani H, Lerat J, Saroul N, Verillaud B, Bartaire E, Céruse P, Clifford GM, Franceschi S, Lacau St Guily J
Oral Oncol 2021 Jun;117:105302. Epub 2021 Apr 24 doi: 10.1016/j.oraloncology.2021.105302. PMID: 33905915
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512

Prognosis

Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
Tonsillectomy and the incidence of various types of cancer.
Holló G
Immunol Res 2021 Dec;69(6):467-470. Epub 2021 Sep 15 doi: 10.1007/s12026-021-09230-3. PMID: 34523058Free PMC Article
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Lymphangioma of the palatine tonsil.
Mardekian S, Karp JK
Arch Pathol Lab Med 2013 Dec;137(12):1837-42. doi: 10.5858/arpa.2012-0678-RS. PMID: 24283866
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590

Clinical prediction guides

Influence of tumor topography on clinical-morphological profile of laryngeal malignancies.
Gheorghe EA, Pleşea IE, Welt LS, Hâlcu G, Foarfă MC, Ioniţă I, Mogoantă CA, Ioniţă E
Rom J Morphol Embryol 2023 Jul-Sep;64(3):319-332. doi: 10.47162/RJME.64.3.04. PMID: 37867350Free PMC Article
Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis.
Petit C, Lee A, Ma J, Lacas B, Ng WT, Chan ATC, Hong RL, Chen MY, Chen L, Li WF, Huang PY, Tan T, Ngan RKC, Zhu G, Mai HQ, Hui EP, Fountzilas G, Zhang L, Carmel A, Kwong DLW, Moon J, Bourhis J, Auperin A, Pignon JP, Blanchard P; MAC-NPC Collaborative Group
Lancet Oncol 2023 Jun;24(6):611-623. doi: 10.1016/S1470-2045(23)00163-8. PMID: 37269842
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Tonsillectomy and the incidence of various types of cancer.
Holló G
Immunol Res 2021 Dec;69(6):467-470. Epub 2021 Sep 15 doi: 10.1007/s12026-021-09230-3. PMID: 34523058Free PMC Article

Recent systematic reviews

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Lawler T, Warren Andersen S
Nutrients 2023 Jan 13;15(2) doi: 10.3390/nu15020422. PMID: 36678292Free PMC Article
Adenoid Ameloblastoma with Dentinoid: A systematic review.
Sachdev SS, Chettiankandy TJ, Sardar MA, Adhane Y, Shah AM, Grace AE
Sultan Qaboos Univ Med J 2022 Aug;22(3):325-338. Epub 2022 Aug 25 doi: 10.18295/squmj.9.2021.127. PMID: 36072074Free PMC Article
Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081

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