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Ocular hypertension

MedGen UID:
10423
•Concept ID:
C0028840
•
Disease or Syndrome
Synonyms: Hypertension, Ocular; Hypertensions, Ocular; Ocular Hypertension; Ocular Hypertensions
SNOMED CT: OH - Ocular hypertension (4210003); OHT - Ocular hypertension (4210003); Ocular hypertension (4210003)
 
Monarch Initiative: MONDO:0006875

Definition

Abnormally high intraocular pressure. [from NCI]

Professional guidelines

PubMed

Glaucoma in Adults-Screening, Diagnosis, and Management: A Review.
Stein JD, Khawaja AP, Weizer JS
JAMA 2021 Jan 12;325(2):164-174. doi: 10.1001/jama.2020.21899. PMID: 33433580
The Diagnosis and Treatment of Glaucoma.
Schuster AK, Erb C, Hoffmann EM, Dietlein T, Pfeiffer N
Dtsch Arztebl Int 2020 Mar 27;117(13):225-234. doi: 10.3238/arztebl.2020.0225. PMID: 32343668Free PMC Article
Steroid-induced glaucoma: Epidemiology, pathophysiology, and clinical management.
Roberti G, Oddone F, Agnifili L, Katsanos A, Michelessi M, Mastropasqua L, Quaranta L, Riva I, Tanga L, Manni G
Surv Ophthalmol 2020 Jul-Aug;65(4):458-472. Epub 2020 Feb 11 doi: 10.1016/j.survophthal.2020.01.002. PMID: 32057761

Recent clinical studies

Etiology

The natural history of untreated ocular hypertension and glaucoma.
Lauwers A, Barbosa Breda J, Stalmans I
Surv Ophthalmol 2023 May-Jun;68(3):388-424. Epub 2022 Dec 21 doi: 10.1016/j.survophthal.2022.12.001. PMID: 36563707
Brimonidine tartrate for the treatment of glaucoma.
Oh DJ, Chen JL, Vajaranant TS, Dikopf MS
Expert Opin Pharmacother 2019 Jan;20(1):115-122. Epub 2018 Nov 8 doi: 10.1080/14656566.2018.1544241. PMID: 30407890
What We Have Learned From the Ocular Hypertension Treatment Study.
Gordon MO, Kass MA
Am J Ophthalmol 2018 May;189:xxiv-xxvii. Epub 2018 Mar 1 doi: 10.1016/j.ajo.2018.02.016. PMID: 29501371Free PMC Article
OCULAR HYPERTENSION AND GLAUCOMA FOLLOWING VITRECTOMY: A Systematic Review.
Miele A, Govetto A, Fumagalli C, Donati S, Biagini I, Azzolini C, Rizzo S, Virgili G
Retina 2018 May;38(5):883-890. doi: 10.1097/IAE.0000000000001651. PMID: 28426628
Uveitic Ocular Hypertension and Glaucoma.
Cunningham ET Jr, Zierhut M
Ocul Immunol Inflamm 2017 Dec;25(6):737-739. doi: 10.1080/09273948.2017.1415077. PMID: 29265966

Diagnosis

The natural history of untreated ocular hypertension and glaucoma.
Lauwers A, Barbosa Breda J, Stalmans I
Surv Ophthalmol 2023 May-Jun;68(3):388-424. Epub 2022 Dec 21 doi: 10.1016/j.survophthal.2022.12.001. PMID: 36563707
Current intravitreal therapy and ocular hypertension: A review.
Sudhalkar A, Bilgic A, Vasavada S, Kodjikian L, Mathis T, de Ribot FM, Papakostas T, Vasavada V, Vasavada V, Srivastava S, Bhojwani D, Ghia P, Sudhalkar A
Indian J Ophthalmol 2021 Feb;69(2):236-243. doi: 10.4103/ijo.IJO_1028_20. PMID: 33463565Free PMC Article
What We Have Learned From the Ocular Hypertension Treatment Study.
Gordon MO, Kass MA
Am J Ophthalmol 2018 May;189:xxiv-xxvii. Epub 2018 Mar 1 doi: 10.1016/j.ajo.2018.02.016. PMID: 29501371Free PMC Article
Uveitic Ocular Hypertension and Glaucoma.
Cunningham ET Jr, Zierhut M
Ocul Immunol Inflamm 2017 Dec;25(6):737-739. doi: 10.1080/09273948.2017.1415077. PMID: 29265966
The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.
Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Kass MA
Arch Ophthalmol 2002 Jun;120(6):714-20; discussion 829-30. doi: 10.1001/archopht.120.6.714. PMID: 12049575

Therapy

Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial: Six-Year Results of Primary Selective Laser Trabeculoplasty versus Eye Drops for the Treatment of Glaucoma and Ocular Hypertension.
Gazzard G, Konstantakopoulou E, Garway-Heath D, Adeleke M, Vickerstaff V, Ambler G, Hunter R, Bunce C, Nathwani N, Barton K; LiGHT Trial Study Group
Ophthalmology 2023 Feb;130(2):139-151. Epub 2022 Sep 17 doi: 10.1016/j.ophtha.2022.09.009. PMID: 36122660
Topical corticosteroids for dry eye.
Liu SH, Saldanha IJ, Abraham AG, Rittiphairoj T, Hauswirth S, Gregory D, Ifantides C, Li T
Cochrane Database Syst Rev 2022 Oct 21;10(10):CD015070. doi: 10.1002/14651858.CD015070.pub2. PMID: 36269562Free PMC Article
Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial.
Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K, Rubin G, Buszewicz M; LiGHT Trial Study Group
Lancet 2019 Apr 13;393(10180):1505-1516. Epub 2019 Mar 9 doi: 10.1016/S0140-6736(18)32213-X. PMID: 30862377Free PMC Article
Laser in Glaucoma and Ocular Hypertension (LiGHT) trial. A multicentre, randomised controlled trial: design and methodology.
Gazzard G, Konstantakopoulou E, Garway-Heath D, Barton K, Wormald R, Morris S, Hunter R, Rubin G, Buszewicz M, Ambler G, Bunce C; LiGHT Trial Study Group
Br J Ophthalmol 2018 May;102(5):593-598. Epub 2017 Sep 13 doi: 10.1136/bjophthalmol-2017-310877. PMID: 28903966
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574

Prognosis

Follow-up studies of the classical landmark studies in Glaucoma.
Meier-Gibbons F, Töteberg-Harms M
Curr Opin Ophthalmol 2023 Mar 1;34(2):116-122. Epub 2022 Nov 7 doi: 10.1097/ICU.0000000000000926. PMID: 36730777
OCULAR HYPERTENSION AND GLAUCOMA FOLLOWING VITRECTOMY: A Systematic Review.
Miele A, Govetto A, Fumagalli C, Donati S, Biagini I, Azzolini C, Rizzo S, Virgili G
Retina 2018 May;38(5):883-890. doi: 10.1097/IAE.0000000000001651. PMID: 28426628
Corneal transplantation and glaucoma.
Haddadin RI, Chodosh J
Semin Ophthalmol 2014 Sep-Nov;29(5-6):380-96. doi: 10.3109/08820538.2014.959201. PMID: 25325864
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574
Pseudophakic glaucoma.
van Oye R, Gelisken O
Int Ophthalmol 1985 Sep;8(3):183-6. doi: 10.1007/BF00136496. PMID: 4066161

Clinical prediction guides

The natural history of untreated ocular hypertension and glaucoma.
Lauwers A, Barbosa Breda J, Stalmans I
Surv Ophthalmol 2023 May-Jun;68(3):388-424. Epub 2022 Dec 21 doi: 10.1016/j.survophthal.2022.12.001. PMID: 36563707
Optic Disc Drusen in Patients With Ocular Hypertension: A Case Series and Review of the Literature.
Kohli D, Chen JJ, Bhatti MT, Moore-Weiss JM, Roddy GW
J Neuroophthalmol 2022 Dec 1;42(4):470-475. Epub 2022 Aug 2 doi: 10.1097/WNO.0000000000001647. PMID: 35916300Free PMC Article
Current intravitreal therapy and ocular hypertension: A review.
Sudhalkar A, Bilgic A, Vasavada S, Kodjikian L, Mathis T, de Ribot FM, Papakostas T, Vasavada V, Vasavada V, Srivastava S, Bhojwani D, Ghia P, Sudhalkar A
Indian J Ophthalmol 2021 Feb;69(2):236-243. doi: 10.4103/ijo.IJO_1028_20. PMID: 33463565Free PMC Article
Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial.
Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K, Rubin G, Buszewicz M; LiGHT Trial Study Group
Lancet 2019 Apr 13;393(10180):1505-1516. Epub 2019 Mar 9 doi: 10.1016/S0140-6736(18)32213-X. PMID: 30862377Free PMC Article
What We Have Learned From the Ocular Hypertension Treatment Study.
Gordon MO, Kass MA
Am J Ophthalmol 2018 May;189:xxiv-xxvii. Epub 2018 Mar 1 doi: 10.1016/j.ajo.2018.02.016. PMID: 29501371Free PMC Article

Recent systematic reviews

Topical corticosteroids for dry eye.
Liu SH, Saldanha IJ, Abraham AG, Rittiphairoj T, Hauswirth S, Gregory D, Ifantides C, Li T
Cochrane Database Syst Rev 2022 Oct 21;10(10):CD015070. doi: 10.1002/14651858.CD015070.pub2. PMID: 36269562Free PMC Article
Alcohol, Intraocular Pressure, and Open-Angle Glaucoma: A Systematic Review and Meta-analysis.
Stuart KV, Madjedi K, Luben RN, Chua SYL, Warwick AN, Chia M, Pasquale LR, Wiggs JL, Kang JH, Hysi PG, Tran JH, Foster PJ, Khawaja AP; Modifiable Risk Factors for Glaucoma Collaboration
Ophthalmology 2022 Jun;129(6):637-652. Epub 2022 Jan 31 doi: 10.1016/j.ophtha.2022.01.023. PMID: 35101531Free PMC Article
OCULAR HYPERTENSION AND GLAUCOMA FOLLOWING VITRECTOMY: A Systematic Review.
Miele A, Govetto A, Fumagalli C, Donati S, Biagini I, Azzolini C, Rizzo S, Virgili G
Retina 2018 May;38(5):883-890. doi: 10.1097/IAE.0000000000001651. PMID: 28426628
Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis.
Li T, Lindsley K, Rouse B, Hong H, Shi Q, Friedman DS, Wormald R, Dickersin K
Ophthalmology 2016 Jan;123(1):129-40. Epub 2015 Oct 31 doi: 10.1016/j.ophtha.2015.09.005. PMID: 26526633Free PMC Article
Glaucoma.
Shah R, Wormald RP
BMJ Clin Evid 2011 Jun 9;2011 PMID: 21658300Free PMC Article

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