U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Urothelial papilloma

MedGen UID:
115999
•Concept ID:
C0235754
•
Neoplastic Process
Synonyms: bladder papilloma; bladder transitional cell papilloma; Papilloma of bladder; Papilloma of urinary bladder; transitional cell papilloma of bladder; uPA; Urinary bladder papilloma; Urothelial Papilloma; urothelial papilloma
SNOMED CT: Urinary bladder papilloma (45083001); Urothelial papilloma (45083001); Papilloma of bladder (45083001); Papilloma of urinary bladder (45083001)
 
Monarch Initiative: MONDO:0004041

Definition

A rare benign neoplasm that arises from the urinary tract and is characterized by the presence of a papillary growth with a central fibrovascular core. The latter is lined by normal urothelium. [from NCI]

Professional guidelines

PubMed

Immunohistochemistry and Fluorescence In Situ Hybridization Can Inform the Differential Diagnosis of Low-Grade Noninvasive Urothelial Carcinoma with an Inverted Growth Pattern and Inverted Urothelial Papilloma.
Sun JJ, Wu Y, Lu YM, Zhang HZ, Wang T, Yang XQ, Sun MH, Wang CF
PLoS One 2015;10(7):e0133530. Epub 2015 Jul 24 doi: 10.1371/journal.pone.0133530. PMID: 26208279Free PMC Article

Recent clinical studies

Etiology

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Urothelial neoplasms in pediatric and young adult patients: A large single-center series.
Saltsman JA, Malek MM, Reuter VE, Hammond WJ, Danzer E, Herr HW, LaQuaglia MP
J Pediatr Surg 2018 Feb;53(2):306-309. Epub 2017 Nov 14 doi: 10.1016/j.jpedsurg.2017.11.024. PMID: 29221636Free PMC Article
MRI Findings of Inverted Urothelial Papilloma of the Bladder.
Takeuchi M, Sasaguri K, Naiki T, Mitsumori A, Ito H, Takahama J, Yamada K, Marugami N, Tsuboyama T, Okumura Y, Ohgiya Y, Kawai N, Kohri K, Shibamoto Y
AJR Am J Roentgenol 2015 Aug;205(2):311-6. doi: 10.2214/AJR.14.13879. PMID: 26204280
Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients.
Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B, Pace G, Carmignani L
Urol Oncol 2013 Nov;31(8):1584-90. Epub 2012 Apr 19 doi: 10.1016/j.urolonc.2012.03.009. PMID: 22520573

Diagnosis

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Mimickers of urothelial neoplasia.
Kryvenko ON, Epstein JI
Ann Diagn Pathol 2019 Feb;38:11-19. Epub 2018 Sep 26 doi: 10.1016/j.anndiagpath.2018.09.012. PMID: 30380401
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Premalignant lesions of the urinary bladder.
Samaratunga H, Martignoni G, Egevad L, Delahunt B
Pathology 2013 Apr;45(3):243-50. doi: 10.1097/PAT.0b013e32835f6169. PMID: 23448810
Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients.
Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B, Pace G, Carmignani L
Urol Oncol 2013 Nov;31(8):1584-90. Epub 2012 Apr 19 doi: 10.1016/j.urolonc.2012.03.009. PMID: 22520573

Therapy

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Mechanical Implantation of Urothelium Into Periureteral Soft Tissue: A Series of 4 Cases Mimicking High-stage Urothelial Carcinoma.
Wobker SE, Aron M, Epstein JI
Am J Surg Pathol 2016 Nov;40(11):1564-1570. doi: 10.1097/PAS.0000000000000731. PMID: 27631511
Transurethral Resection of the Bladder Tumour as a Treatment Method in Children with Transitional Cell Carcinoma of the Bladder--Analysis of Our Material and Literature Review.
Apoznański W, Rysiakiewicz J, Polok M, Rysiakiewicz K, Siekanowicz P, Hilger T, Zagierski J, Hilger M, Nowak I, Kolęda P, Szydełko T
Adv Clin Exp Med 2015 May-Jun;24(3):505-9. doi: 10.17219/acem/36600. PMID: 26467141

Prognosis

Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ.
Yao Z, Xu N, Shang G, Wang H, Tao H, Wang Y, Qin Z, Tan S, Feng J, Zhu J, Ma F, Tian S, Zhang Q, Qu Y, Hou J, Guo J, Zhao J, Hou Y, Ding C
Nat Commun 2023 Sep 13;14(1):5670. doi: 10.1038/s41467-023-41139-3. PMID: 37704624Free PMC Article
Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Genomic landscape of inverted urothelial papilloma and urothelial papilloma of the bladder.
Isharwal S, Hu W, Sarungbam J, Chen YB, Gopalan A, Fine SW, Tickoo SK, Sirintrapun SJ, Jadallah S, Loo FL, Pietzak EJ, Cha EK, Bochner BH, Berger MF, Iyer G, Solit DB, Reuter VE, Al-Ahmadie H
J Pathol 2019 Jul;248(3):260-265. Epub 2019 Apr 22 doi: 10.1002/path.5261. PMID: 30838648Free PMC Article
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients.
Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B, Pace G, Carmignani L
Urol Oncol 2013 Nov;31(8):1584-90. Epub 2012 Apr 19 doi: 10.1016/j.urolonc.2012.03.009. PMID: 22520573

Clinical prediction guides

RAS Family Gene Mutations, Clinicopathological Features, and Spread Patterns of Inverted Urothelial Papilloma of the Bladder.
Kitahama K, Shigematsu Y, Amori G, Sugawara E, Yonese J, Shibahara J, Takeuchi K, Inamura K
Am J Surg Pathol 2024 Apr 1;48(4):458-464. Epub 2023 Dec 25 doi: 10.1097/PAS.0000000000002171. PMID: 38145408
A retrospective study on expression and clinical significance of PHH3, Ki67 and P53 in bladder exophytic papillary urothelial neoplasms.
Qi G, Liu J, Tao S, Fan W, Zheng H, Wang M, Yang H, Liu Y, Liu H, Zhou F
PeerJ 2023;11:e15675. Epub 2023 Jul 11 doi: 10.7717/peerj.15675. PMID: 37456895Free PMC Article
Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Inverted urothelial papilloma: is ploidy, MIB-1 proliferative activity, or p53 protein accumulation predictive of urothelial carcinoma?
Cheville JC, Wu K, Sebo TJ, Cheng L, Riehle D, Lohse CM, Shane V
Cancer 2000 Feb 1;88(3):632-6. doi: 10.1002/(sici)1097-0142(20000201)88:3<632::aid-cncr21>3.0.co;2-f. PMID: 10649258

Recent systematic reviews

Inverted urothelial papilloma of the upper urinary tract: description of two cases with systematic literature review.
Santi R, Galli IC, Canzonieri V, Lopez JI, Nesi G
Diagn Pathol 2020 Apr 22;15(1):40. doi: 10.1186/s13000-020-00961-9. PMID: 32321559Free PMC Article
Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients.
Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B, Pace G, Carmignani L
Urol Oncol 2013 Nov;31(8):1584-90. Epub 2012 Apr 19 doi: 10.1016/j.urolonc.2012.03.009. PMID: 22520573

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...